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[Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery].
Rev Esp Cardiol. 2006 Dec; 59(12):1252-60.RE

Abstract

INTRODUCTION AND OBJECTIVES

The high level of metabolic activity present in visceral adipose tissue is associated with the development of atherothrombosis. Subcutaneous adipose tissue secretes larger quantities of the adipocytokines leptin and adiponectin than visceral adipose tissue. Epicardial adipose tissue secretes inflammatory mediators, and the resulting proinflammatory activity is greater than that associated with subcutaneous adipose tissue. The aim of this study was to compare adiponectin and leptin expression in human epicardial and subcutaneous adipose tissue.

METHODS

Samples of both epicardial and subcutaneous adipose tissue were taken from 46 patients who were undergoing heart surgery, coronary artery bypass surgery, or aortic or mitral valve replacement. Levels of protein and gene expression of leptin and adiponectin were assessed immunohistochemically and by RT-PCR, respectively. Levels of mRNA expression in the 2 adipose tissue types were compared by real-time quantitative PCR.

RESULTS

Significant differences were found between adiponectin and leptin mRNA expression in epicardial and subcutaneous adipose tissue, with epicardial adipose tissue exhibiting lower levels of adiponectin and leptin expression. Moreover, adiponectin and leptin mRNA expression in epicardial adipose tissue was higher in women than men.

CONCLUSIONS

Adiponectin and leptin expression is lower in epicardial than in subcutaneous adipose tissue. Moreover, there are differences in adiponectin and leptin expression in epicardial adipose tissue between women and men.

Authors+Show Affiliations

Unidad de Investigación en Cardiología Celular y Molecular, Servicio de Cardiología, Hospital Clínico Universitario de Santiago de Compostela, A Coruña, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

17194420

Citation

Iglesias, María J., et al. "[Gender Differences in Adiponectin and Leptin Expression in Epicardial and Subcutaneous Adipose Tissue. Findings in Patients Undergoing Cardiac Surgery]." Revista Espanola De Cardiologia, vol. 59, no. 12, 2006, pp. 1252-60.
Iglesias MJ, Eiras S, Piñeiro R, et al. [Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery]. Rev Esp Cardiol. 2006;59(12):1252-60.
Iglesias, M. J., Eiras, S., Piñeiro, R., López-Otero, D., Gallego, R., Fernández, A. L., Lago, F., & González-Juanatey, J. R. (2006). [Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery]. Revista Espanola De Cardiologia, 59(12), 1252-60.
Iglesias MJ, et al. [Gender Differences in Adiponectin and Leptin Expression in Epicardial and Subcutaneous Adipose Tissue. Findings in Patients Undergoing Cardiac Surgery]. Rev Esp Cardiol. 2006;59(12):1252-60. PubMed PMID: 17194420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery]. AU - Iglesias,María J, AU - Eiras,Sonia, AU - Piñeiro,Roberto, AU - López-Otero,Diego, AU - Gallego,Rosalía, AU - Fernández,Angel L, AU - Lago,Francisca, AU - González-Juanatey,José R, PY - 2006/12/30/pubmed PY - 2007/3/21/medline PY - 2006/12/30/entrez SP - 1252 EP - 60 JF - Revista espanola de cardiologia JO - Rev Esp Cardiol VL - 59 IS - 12 N2 - INTRODUCTION AND OBJECTIVES: The high level of metabolic activity present in visceral adipose tissue is associated with the development of atherothrombosis. Subcutaneous adipose tissue secretes larger quantities of the adipocytokines leptin and adiponectin than visceral adipose tissue. Epicardial adipose tissue secretes inflammatory mediators, and the resulting proinflammatory activity is greater than that associated with subcutaneous adipose tissue. The aim of this study was to compare adiponectin and leptin expression in human epicardial and subcutaneous adipose tissue. METHODS: Samples of both epicardial and subcutaneous adipose tissue were taken from 46 patients who were undergoing heart surgery, coronary artery bypass surgery, or aortic or mitral valve replacement. Levels of protein and gene expression of leptin and adiponectin were assessed immunohistochemically and by RT-PCR, respectively. Levels of mRNA expression in the 2 adipose tissue types were compared by real-time quantitative PCR. RESULTS: Significant differences were found between adiponectin and leptin mRNA expression in epicardial and subcutaneous adipose tissue, with epicardial adipose tissue exhibiting lower levels of adiponectin and leptin expression. Moreover, adiponectin and leptin mRNA expression in epicardial adipose tissue was higher in women than men. CONCLUSIONS: Adiponectin and leptin expression is lower in epicardial than in subcutaneous adipose tissue. Moreover, there are differences in adiponectin and leptin expression in epicardial adipose tissue between women and men. SN - 1579-2242 UR - https://www.unboundmedicine.com/medline/citation/17194420/[Gender_differences_in_adiponectin_and_leptin_expression_in_epicardial_and_subcutaneous_adipose_tissue__Findings_in_patients_undergoing_cardiac_surgery]_ L2 - http://www.revespcardiol.org/en/linksolver/ft/ivp/0300-8932/59/1252 DB - PRIME DP - Unbound Medicine ER -