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Hepatitis in marmosets.

Abstract

Some species of marmosets are susceptible, not only by parenteral inoculation but also by oral exposure, to human hepatitis A virus present in sera or feces. The stools of animals inoculated parenterally or orally contained fecal antigen during certain times of the incubation period and the early, acute phase of the disease; viruslike particles were present in feces of orally infected animals and such feces were infectious when inoculated into marmosets. The fecal antigen crossreacted both with the fecal virus particles and the immune-adherence antigen (see also papers by Purcell et al and Hilleman et al). The MS-1 and CR-326 strains of hepatitis A appeared antigenically similar or identical whereas the GB strain was antigenically different and may be associated with the recently defined type of hepatitis termed hepatitis C or hepatitis non-A/non-B. On repeated challenge hyperegic responses with diffuse liver cell necrosis occurred in some immune animals and this phenomenon must be taken into account in any future vaccination studies.

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  • Authors

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    Source

    MeSH

    Animals
    Antibodies, Viral
    Antigen-Antibody Reactions
    Callitrichinae
    Feces
    Guinea Pigs
    Hepatitis A
    Hepatitis B Antigens
    Hepatitis Viruses
    Hepatovirus
    Humans
    Immune Adherence Reaction
    Immunity
    Liver
    Necrosis
    Rabbits

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    171953

    Citation

    Deinhardt, F, et al. "Hepatitis in Marmosets." The American Journal of the Medical Sciences, vol. 270, no. 1, 1975, pp. 73-80.
    Deinhardt F, Peterson D, Cross G, et al. Hepatitis in marmosets. Am J Med Sci. 1975;270(1):73-80.
    Deinhardt, F., Peterson, D., Cross, G., Wolfe, L., & Holmes, A. W. (1975). Hepatitis in marmosets. The American Journal of the Medical Sciences, 270(1), pp. 73-80.
    Deinhardt F, et al. Hepatitis in Marmosets. Am J Med Sci. 1975;270(1):73-80. PubMed PMID: 171953.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatitis in marmosets. AU - Deinhardt,F, AU - Peterson,D, AU - Cross,G, AU - Wolfe,L, AU - Holmes,A W, PY - 1975/7/1/pubmed PY - 1975/7/1/medline PY - 1975/7/1/entrez SP - 73 EP - 80 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 270 IS - 1 N2 - Some species of marmosets are susceptible, not only by parenteral inoculation but also by oral exposure, to human hepatitis A virus present in sera or feces. The stools of animals inoculated parenterally or orally contained fecal antigen during certain times of the incubation period and the early, acute phase of the disease; viruslike particles were present in feces of orally infected animals and such feces were infectious when inoculated into marmosets. The fecal antigen crossreacted both with the fecal virus particles and the immune-adherence antigen (see also papers by Purcell et al and Hilleman et al). The MS-1 and CR-326 strains of hepatitis A appeared antigenically similar or identical whereas the GB strain was antigenically different and may be associated with the recently defined type of hepatitis termed hepatitis C or hepatitis non-A/non-B. On repeated challenge hyperegic responses with diffuse liver cell necrosis occurred in some immune animals and this phenomenon must be taken into account in any future vaccination studies. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/171953/Hepatitis_in_marmosets_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=171953.ui DB - PRIME DP - Unbound Medicine ER -