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Review of infectivity studies in nonhuman primates with virus-like particles associated with MS-1 hepatitis.

Abstract

Using the technique of immune electron microscopy we have conducted hepatitis A infectivity studies in marmoset monkeys and chimpanzees. Marmosets inoculated with human serum containing the MS-1 strain of hepatitis A virus have developed hepatitis and seroconverted to 27 nm virus-like particles isolated from stools of humans in the early acute stages of hepatitis. Similar results have been observed through several marmoset subpassages, and the virus-like particles have been recovered from the liver of animals in the acute phase of hepatitis. Chimpanzees inoculated with stool filtrates containing the virus-like particles develop hepatitis with concomitant excretion of the particles in early acute phase stools and subsequent development of serum antibody to the particles. These studies provide evidence that the above particles constitute the virus of hepatitis A of the MS-1 prototype.

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  • Authors

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    Source

    MeSH

    Acute Disease
    Animals
    Antibodies, Viral
    Antibody Formation
    Callitrichinae
    Feces
    Hepatitis A
    Hepatitis B Antigens
    Hepatitis Viruses
    Hepatovirus
    Humans
    Liver
    Pan troglodytes

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    171954

    Citation

    Maynard, J E., et al. "Review of Infectivity Studies in Nonhuman Primates With Virus-like Particles Associated With MS-1 Hepatitis." The American Journal of the Medical Sciences, vol. 270, no. 1, 1975, pp. 81-5.
    Maynard JE, Lorenz D, Bradley DW, et al. Review of infectivity studies in nonhuman primates with virus-like particles associated with MS-1 hepatitis. Am J Med Sci. 1975;270(1):81-5.
    Maynard, J. E., Lorenz, D., Bradley, D. W., Feinstone, S. M., Krushak, D. H., Barker, L. F., & Purcell, R. H. (1975). Review of infectivity studies in nonhuman primates with virus-like particles associated with MS-1 hepatitis. The American Journal of the Medical Sciences, 270(1), pp. 81-5.
    Maynard JE, et al. Review of Infectivity Studies in Nonhuman Primates With Virus-like Particles Associated With MS-1 Hepatitis. Am J Med Sci. 1975;270(1):81-5. PubMed PMID: 171954.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Review of infectivity studies in nonhuman primates with virus-like particles associated with MS-1 hepatitis. AU - Maynard,J E, AU - Lorenz,D, AU - Bradley,D W, AU - Feinstone,S M, AU - Krushak,D H, AU - Barker,L F, AU - Purcell,R H, PY - 1975/7/1/pubmed PY - 1975/7/1/medline PY - 1975/7/1/entrez SP - 81 EP - 5 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 270 IS - 1 N2 - Using the technique of immune electron microscopy we have conducted hepatitis A infectivity studies in marmoset monkeys and chimpanzees. Marmosets inoculated with human serum containing the MS-1 strain of hepatitis A virus have developed hepatitis and seroconverted to 27 nm virus-like particles isolated from stools of humans in the early acute stages of hepatitis. Similar results have been observed through several marmoset subpassages, and the virus-like particles have been recovered from the liver of animals in the acute phase of hepatitis. Chimpanzees inoculated with stool filtrates containing the virus-like particles develop hepatitis with concomitant excretion of the particles in early acute phase stools and subsequent development of serum antibody to the particles. These studies provide evidence that the above particles constitute the virus of hepatitis A of the MS-1 prototype. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/171954/Review_of_infectivity_studies_in_nonhuman_primates_with_virus_like_particles_associated_with_MS_1_hepatitis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=171954.ui DB - PRIME DP - Unbound Medicine ER -