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Meta-analysis of the studies assessing temporal changes in coronary plaque volume using intravascular ultrasound.
Am J Cardiol. 2007 Jan 01; 99(1):5-10.AJ

Abstract

To assess the temporal effect of statin therapy on coronary atherosclerotic plaque volume measured by intravascular ultrasound (IVUS), we searched PubMed for eligible studies published between 1990 and January 2006. Inclusion criteria for retrieved studies were (1) IVUS volume analysis at baseline and follow-up and (2) statin therapy in > or =1 group of patients. All data of interest were abstracted in prespecified structured collection forms. Statistical analysis was performed with Review Manager 4.2. Random-effect weighted mean difference (WMD) was used as summary statistics for comparison of continuous variables. Nine studies of 985 patients (with 11 statin treatment arms) were selected. After a mean follow-up of 9.8 +/- 4.9 months, we found a significant decrease in coronary plaque volume (WMD -5.77 mm(3), 95% confidence interval -10.36 to -1.17, p = 0.01), with no significant heterogeneity across studies (p = 0.47). Prespecified subgroup analyses showed similar trends. Studies in which the achieved low-density lipoprotein (LDL) cholesterol level was <100 mg/dl showed a trend for plaque regression (WMD -7.88 mm(3), 95% confidence interval -16.31 to 0.55, p = 0.07), whereas studies in which the achieved level of LDL cholesterol was > or =100 mg/dl, the trend was less evident (WMD -4.22 mm(3), 95% confidence interval -10.27 to 1.82, p = 0.17). Plaque volume remained essentially unchanged in patients not treated with statins (WMD 0.13 mm(3), 95% confidence interval -4.42 to 4.68, p = 0.96). In conclusion, statin therapy, particularly when achieving the target LDL level, appears to promote a significant regression of coronary plaque volume as measured by IVUS.

Authors+Show Affiliations

Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. grodriguezgranillo@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

17196453

Citation

Rodriguez-Granillo, Gastón A., et al. "Meta-analysis of the Studies Assessing Temporal Changes in Coronary Plaque Volume Using Intravascular Ultrasound." The American Journal of Cardiology, vol. 99, no. 1, 2007, pp. 5-10.
Rodriguez-Granillo GA, Agostoni P, Garcia-Garcia HM, et al. Meta-analysis of the studies assessing temporal changes in coronary plaque volume using intravascular ultrasound. Am J Cardiol. 2007;99(1):5-10.
Rodriguez-Granillo, G. A., Agostoni, P., Garcia-Garcia, H. M., Biondi-Zoccai, G. G., McFadden, E., Amoroso, G., de Jaegere, P., Bruining, N., de Feyter, P., & Serruys, P. W. (2007). Meta-analysis of the studies assessing temporal changes in coronary plaque volume using intravascular ultrasound. The American Journal of Cardiology, 99(1), 5-10.
Rodriguez-Granillo GA, et al. Meta-analysis of the Studies Assessing Temporal Changes in Coronary Plaque Volume Using Intravascular Ultrasound. Am J Cardiol. 2007 Jan 1;99(1):5-10. PubMed PMID: 17196453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of the studies assessing temporal changes in coronary plaque volume using intravascular ultrasound. AU - Rodriguez-Granillo,Gastón A, AU - Agostoni,Pierfrancesco, AU - Garcia-Garcia,Héctor M, AU - Biondi-Zoccai,Giuseppe G L, AU - McFadden,Eugène, AU - Amoroso,Giovanni, AU - de Jaegere,Peter, AU - Bruining,Nico, AU - de Feyter,Pim, AU - Serruys,Patrick W, Y1 - 2006/11/03/ PY - 2006/04/18/received PY - 2006/07/13/revised PY - 2006/07/13/accepted PY - 2007/1/2/pubmed PY - 2007/2/9/medline PY - 2007/1/2/entrez SP - 5 EP - 10 JF - The American journal of cardiology JO - Am J Cardiol VL - 99 IS - 1 N2 - To assess the temporal effect of statin therapy on coronary atherosclerotic plaque volume measured by intravascular ultrasound (IVUS), we searched PubMed for eligible studies published between 1990 and January 2006. Inclusion criteria for retrieved studies were (1) IVUS volume analysis at baseline and follow-up and (2) statin therapy in > or =1 group of patients. All data of interest were abstracted in prespecified structured collection forms. Statistical analysis was performed with Review Manager 4.2. Random-effect weighted mean difference (WMD) was used as summary statistics for comparison of continuous variables. Nine studies of 985 patients (with 11 statin treatment arms) were selected. After a mean follow-up of 9.8 +/- 4.9 months, we found a significant decrease in coronary plaque volume (WMD -5.77 mm(3), 95% confidence interval -10.36 to -1.17, p = 0.01), with no significant heterogeneity across studies (p = 0.47). Prespecified subgroup analyses showed similar trends. Studies in which the achieved low-density lipoprotein (LDL) cholesterol level was <100 mg/dl showed a trend for plaque regression (WMD -7.88 mm(3), 95% confidence interval -16.31 to 0.55, p = 0.07), whereas studies in which the achieved level of LDL cholesterol was > or =100 mg/dl, the trend was less evident (WMD -4.22 mm(3), 95% confidence interval -10.27 to 1.82, p = 0.17). Plaque volume remained essentially unchanged in patients not treated with statins (WMD 0.13 mm(3), 95% confidence interval -4.42 to 4.68, p = 0.96). In conclusion, statin therapy, particularly when achieving the target LDL level, appears to promote a significant regression of coronary plaque volume as measured by IVUS. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17196453/Meta_analysis_of_the_studies_assessing_temporal_changes_in_coronary_plaque_volume_using_intravascular_ultrasound_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(06)01808-X DB - PRIME DP - Unbound Medicine ER -