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Debate on annual influenza vaccination in healthcare workers for the same subtype under the vaccine shortage.

Abstract

BACKGROUND

Influenza vaccination is the primary method for preventing influenza and its severe complications. Healthcare workers (HCWs) are one of the priority groups for the influenza vaccination.

OBJECTIVES

To determine whether healthy HCWs, who were vaccinated with the same subtype for the two previous years, could be given less priority for influenza immunization under the vaccine shortage.

STUDY DESIGN

We measured hemagglutination-inhibition antibody titers from sequential serum samples in 50 pre-immune subjects and 50 age-matched vaccine-naive subjects: immediately prior to the administration of the vaccine, 4-6 weeks, and 6 months after the vaccination.

RESULTS

Prevaccination titers were maintained above protective level and high protection rates were observed for all three strains in pre-immune subjects: A/H1N1, A/H3N2, and B strains. As for the sequential changes, the protection rates for all three strains still remained above 70% until 6 months following the vaccination.

CONCLUSION

Skipping influenza vaccination for a year could be considered in healthy pre-immune HCWs under the epidemic of the same subtype as two previous years.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Infectious Diseases, Department of Internal Medicine, Korea University, Seoul, Republic of Korea.

    , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Antibodies, Viral
    Health Personnel
    Humans
    Influenza A Virus, H1N1 Subtype
    Influenza A Virus, H3N2 Subtype
    Influenza B virus
    Influenza Vaccines
    Middle Aged
    Prospective Studies

    Pub Type(s)

    Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    17196876

    Citation

    Song, Joon Young, et al. "Debate On Annual Influenza Vaccination in Healthcare Workers for the Same Subtype Under the Vaccine Shortage." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 38, no. 2, 2007, pp. 149-52.
    Song JY, Ha SH, Kee SY, et al. Debate on annual influenza vaccination in healthcare workers for the same subtype under the vaccine shortage. J Clin Virol. 2007;38(2):149-52.
    Song, J. Y., Ha, S. H., Kee, S. Y., Jeong, H. W., Cheong, H. J., & Kim, W. J. (2007). Debate on annual influenza vaccination in healthcare workers for the same subtype under the vaccine shortage. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 38(2), pp. 149-52.
    Song JY, et al. Debate On Annual Influenza Vaccination in Healthcare Workers for the Same Subtype Under the Vaccine Shortage. J Clin Virol. 2007;38(2):149-52. PubMed PMID: 17196876.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Debate on annual influenza vaccination in healthcare workers for the same subtype under the vaccine shortage. AU - Song,Joon Young, AU - Ha,Seok Hoon, AU - Kee,Sae Yoon, AU - Jeong,Hye Won, AU - Cheong,Hee Jin, AU - Kim,Woo Joo, Y1 - 2006/12/29/ PY - 2006/02/25/received PY - 2006/08/22/revised PY - 2006/08/31/accepted PY - 2007/1/2/pubmed PY - 2007/3/30/medline PY - 2007/1/2/entrez SP - 149 EP - 52 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J. Clin. Virol. VL - 38 IS - 2 N2 - BACKGROUND: Influenza vaccination is the primary method for preventing influenza and its severe complications. Healthcare workers (HCWs) are one of the priority groups for the influenza vaccination. OBJECTIVES: To determine whether healthy HCWs, who were vaccinated with the same subtype for the two previous years, could be given less priority for influenza immunization under the vaccine shortage. STUDY DESIGN: We measured hemagglutination-inhibition antibody titers from sequential serum samples in 50 pre-immune subjects and 50 age-matched vaccine-naive subjects: immediately prior to the administration of the vaccine, 4-6 weeks, and 6 months after the vaccination. RESULTS: Prevaccination titers were maintained above protective level and high protection rates were observed for all three strains in pre-immune subjects: A/H1N1, A/H3N2, and B strains. As for the sequential changes, the protection rates for all three strains still remained above 70% until 6 months following the vaccination. CONCLUSION: Skipping influenza vaccination for a year could be considered in healthy pre-immune HCWs under the epidemic of the same subtype as two previous years. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/17196876/Debate_on_annual_influenza_vaccination_in_healthcare_workers_for_the_same_subtype_under_the_vaccine_shortage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(06)00323-4 DB - PRIME DP - Unbound Medicine ER -