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Is the seasonal variation in cancer prognosis caused by sun-induced folate degradation?
Med Hypotheses. 2007; 69(1):182-5.MH

Abstract

Recently, we have documented that the season of diagnosis affects the prognosis of Hodgkin's lymphoma, colon-, breast- and prostate-cancer patients in Norway. The relative risk of death was lower for the patients diagnosed during summer and autumn when compared with the winter diagnosis. We here hypothesise that UV (ultraviolet) induced degradation of folate may be the reason for the observed seasonal variations in cancer prognosis. It is known that folic acid, a synthetic form of folate, is degraded by UV radiation. We have also found that the most common folate derivative in the human body, 5-methyltetrahydrofolate, is UV sensitive.

Authors+Show Affiliations

Department of Radiation Biology, Institute for Cancer Research, Health Enterprise, Rikshospitalet - Radiumhospitalet, Montebello, N-0310 Oslo, Norway. arnfinn.hykkerud.steindal@rr-research.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17197108

Citation

Steindal, Arnfinn Hykkerud, et al. "Is the Seasonal Variation in Cancer Prognosis Caused By Sun-induced Folate Degradation?" Medical Hypotheses, vol. 69, no. 1, 2007, pp. 182-5.
Steindal AH, Porojnicu AC, Moan J. Is the seasonal variation in cancer prognosis caused by sun-induced folate degradation? Med Hypotheses. 2007;69(1):182-5.
Steindal, A. H., Porojnicu, A. C., & Moan, J. (2007). Is the seasonal variation in cancer prognosis caused by sun-induced folate degradation? Medical Hypotheses, 69(1), 182-5.
Steindal AH, Porojnicu AC, Moan J. Is the Seasonal Variation in Cancer Prognosis Caused By Sun-induced Folate Degradation. Med Hypotheses. 2007;69(1):182-5. PubMed PMID: 17197108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the seasonal variation in cancer prognosis caused by sun-induced folate degradation? AU - Steindal,Arnfinn Hykkerud, AU - Porojnicu,Alina Carmen, AU - Moan,Johan, Y1 - 2007/01/02/ PY - 2006/07/04/received PY - 2006/07/06/accepted PY - 2007/1/2/pubmed PY - 2007/7/19/medline PY - 2007/1/2/entrez SP - 182 EP - 5 JF - Medical hypotheses JO - Med Hypotheses VL - 69 IS - 1 N2 - Recently, we have documented that the season of diagnosis affects the prognosis of Hodgkin's lymphoma, colon-, breast- and prostate-cancer patients in Norway. The relative risk of death was lower for the patients diagnosed during summer and autumn when compared with the winter diagnosis. We here hypothesise that UV (ultraviolet) induced degradation of folate may be the reason for the observed seasonal variations in cancer prognosis. It is known that folic acid, a synthetic form of folate, is degraded by UV radiation. We have also found that the most common folate derivative in the human body, 5-methyltetrahydrofolate, is UV sensitive. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/17197108/Is_the_seasonal_variation_in_cancer_prognosis_caused_by_sun_induced_folate_degradation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(06)00809-7 DB - PRIME DP - Unbound Medicine ER -