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[Hemorheologic and circulatory effects of hemodilution with medium molecular weight hydroxyethyl starch in two concentrations (HAES 200/0.62 10% and 6%)].
Acta Med Austriaca. 1991; 18 Suppl 1:9-15.AM

Abstract

This study was designed to investigate whether the positive effect occurring after infusion of a 10% hydroxyethyl starch solution 200.000/0.62 on cutaneous capillary blood flow could still be increased by using a 6% solution having a lower initial viscosity (HES 6% 200.000/0.62). A single blind study of 10 female volunteers was carried out to study the influence of a hypervolemic hemodilution using 500 ml of a 10% solution hydroxyethyl starch solution at first and that of 6% hydroxyethyl starch solution on macro- and microcirculation, transcutaneous oxygen partial pressure and blood fluidity. After hydroxyethyl starch infusion blood flow in the macro- and microvessels increased significantly. This increase occurred considerably earlier after administration of 6% solution than after infusion of 10% solution. Thus blood flow had already increased after 1 hour and continued to show a tendency of increase over about three hours. 6 hours after end of infusion blood flow had almost dropped to its initial value. The volume effect of the 6% solution immediately after infusion was less pronounced than that after infusion of the 10% solution, but it reached the value of the 10% solution at a later point in time. The course of the haematocrit reflected this process. Average decrease in haematocrit value compared to that following the 10% solution was not as pronounced at hour 3. After 6 hours the decreases were comparable. Similar observations were made of plasma viscosity and platelet aggregation. One hour after infusion plasma viscosity and erythrocyte aggregation had hardly changed but haematocrit had clearly dropped. Thus, blood viscosity at this point in time was essentially lowered.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Abteilung für Klinische Hämostaseologie und Transfusionsmedizin, Universität des Saarlandes, Homburg/Saar, BRD.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

ger

PubMed ID

1719736

Citation

Jung, F, et al. "[Hemorheologic and Circulatory Effects of Hemodilution With Medium Molecular Weight Hydroxyethyl Starch in Two Concentrations (HAES 200/0.62 10% and 6%)]." Acta Medica Austriaca, vol. 18 Suppl 1, 1991, pp. 9-15.
Jung F, Waldhausen P, Spitzer S, et al. [Hemorheologic and circulatory effects of hemodilution with medium molecular weight hydroxyethyl starch in two concentrations (HAES 200/0.62 10% and 6%)]. Acta Med Austriaca. 1991;18 Suppl 1:9-15.
Jung, F., Waldhausen, P., Spitzer, S., & Wenzel, E. (1991). [Hemorheologic and circulatory effects of hemodilution with medium molecular weight hydroxyethyl starch in two concentrations (HAES 200/0.62 10% and 6%)]. Acta Medica Austriaca, 18 Suppl 1, 9-15.
Jung F, et al. [Hemorheologic and Circulatory Effects of Hemodilution With Medium Molecular Weight Hydroxyethyl Starch in Two Concentrations (HAES 200/0.62 10% and 6%)]. Acta Med Austriaca. 1991;18 Suppl 1:9-15. PubMed PMID: 1719736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hemorheologic and circulatory effects of hemodilution with medium molecular weight hydroxyethyl starch in two concentrations (HAES 200/0.62 10% and 6%)]. AU - Jung,F, AU - Waldhausen,P, AU - Spitzer,S, AU - Wenzel,E, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 9 EP - 15 JF - Acta medica Austriaca JO - Acta Med Austriaca VL - 18 Suppl 1 N2 - This study was designed to investigate whether the positive effect occurring after infusion of a 10% hydroxyethyl starch solution 200.000/0.62 on cutaneous capillary blood flow could still be increased by using a 6% solution having a lower initial viscosity (HES 6% 200.000/0.62). A single blind study of 10 female volunteers was carried out to study the influence of a hypervolemic hemodilution using 500 ml of a 10% solution hydroxyethyl starch solution at first and that of 6% hydroxyethyl starch solution on macro- and microcirculation, transcutaneous oxygen partial pressure and blood fluidity. After hydroxyethyl starch infusion blood flow in the macro- and microvessels increased significantly. This increase occurred considerably earlier after administration of 6% solution than after infusion of 10% solution. Thus blood flow had already increased after 1 hour and continued to show a tendency of increase over about three hours. 6 hours after end of infusion blood flow had almost dropped to its initial value. The volume effect of the 6% solution immediately after infusion was less pronounced than that after infusion of the 10% solution, but it reached the value of the 10% solution at a later point in time. The course of the haematocrit reflected this process. Average decrease in haematocrit value compared to that following the 10% solution was not as pronounced at hour 3. After 6 hours the decreases were comparable. Similar observations were made of plasma viscosity and platelet aggregation. One hour after infusion plasma viscosity and erythrocyte aggregation had hardly changed but haematocrit had clearly dropped. Thus, blood viscosity at this point in time was essentially lowered.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0303-8173 UR - https://www.unboundmedicine.com/medline/citation/1719736/[Hemorheologic_and_circulatory_effects_of_hemodilution_with_medium_molecular_weight_hydroxyethyl_starch_in_two_concentrations__HAES_200/0_62_10_and_6_]_ DB - PRIME DP - Unbound Medicine ER -