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Reduction in mother-to-child transmission of HIV in Thailand, 2001-2003: Results from population-based surveillance in six provinces.
AIDS. 2007 Jan 11; 21(2):145-51.AIDS

Abstract

BACKGROUND

In 2000, Thailand implemented a national program to prevent mother-to-child HIV transmission (PMTCT).

OBJECTIVE

To describe the effectiveness of the prevention of mother-to-child HIV transmission program in Thailand.

DESIGN AND METHODS

A register of HIV-exposed children at birth was created with follow-up of infection status. The register included children born to HIV-infected women between 1 January 2001 and 31 December 2003 at 84 public health hospitals in six provinces of Thailand. The main outcome measure was HIV infection in children.

RESULTS

A total of 2200 children born to HIV-infected mothers were registered. Of these mother-infant pairs, 2105 (95.7%) received some antiretroviral prophylaxis, including 1358 (61.7%) who received the complete short-course zidovudine regimen during pregnancy and labor for the mother and after birth for the infant, with or without other antiretrovirals. HIV infection outcome was determined for 1667 (75.8%) children, of whom 158 [9.5%, 95% confidence interval (CI), 8.1-11.0%] were infected. Transmission risk was 6.8% (95% CI 5.2-8.9%) among 761 mother-infant pairs that received the complete zidovudine regimen alone, and 3.9% (95% CI, 2.2-6.6%) among 361 mother-infant pairs that received the complete zidovudine regimen combined with other antiretrovirals, usually nevirapine. The overall transmission risk from this cohort, including all antiretroviral prophylaxis combinations, is estimated to be 10.2%.

CONCLUSIONS

The Thai national PMTCT program is effective in reducing mother-to-child transmission risk from the historical risk of 18.9-24.2%. The addition of nevirapine to short-course zidovudine beginning in 2004 may further improve program effectiveness in Thailand.

Authors+Show Affiliations

Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

17197804

Citation

Plipat, Tanarak, et al. "Reduction in Mother-to-child Transmission of HIV in Thailand, 2001-2003: Results From Population-based Surveillance in Six Provinces." AIDS (London, England), vol. 21, no. 2, 2007, pp. 145-51.
Plipat T, Naiwatanakul T, Rattanasuporn N, et al. Reduction in mother-to-child transmission of HIV in Thailand, 2001-2003: Results from population-based surveillance in six provinces. AIDS. 2007;21(2):145-51.
Plipat, T., Naiwatanakul, T., Rattanasuporn, N., Sangwanloy, O., Amornwichet, P., Teeraratkul, A., Ungchusak, K., Mock, P., Levine, W., McConnell, M. S., Simonds, R., & Culnane, M. (2007). Reduction in mother-to-child transmission of HIV in Thailand, 2001-2003: Results from population-based surveillance in six provinces. AIDS (London, England), 21(2), 145-51.
Plipat T, et al. Reduction in Mother-to-child Transmission of HIV in Thailand, 2001-2003: Results From Population-based Surveillance in Six Provinces. AIDS. 2007 Jan 11;21(2):145-51. PubMed PMID: 17197804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction in mother-to-child transmission of HIV in Thailand, 2001-2003: Results from population-based surveillance in six provinces. AU - Plipat,Tanarak, AU - Naiwatanakul,Thananda, AU - Rattanasuporn,Niramon, AU - Sangwanloy,Orapan, AU - Amornwichet,Pornsinee, AU - Teeraratkul,Achara, AU - Ungchusak,Kumnuan, AU - Mock,Philip, AU - Levine,William, AU - McConnell,Michelle S, AU - Simonds,Rj, AU - Culnane,Mary, PY - 2007/1/2/pubmed PY - 2007/3/30/medline PY - 2007/1/2/entrez SP - 145 EP - 51 JF - AIDS (London, England) JO - AIDS VL - 21 IS - 2 N2 - BACKGROUND: In 2000, Thailand implemented a national program to prevent mother-to-child HIV transmission (PMTCT). OBJECTIVE: To describe the effectiveness of the prevention of mother-to-child HIV transmission program in Thailand. DESIGN AND METHODS: A register of HIV-exposed children at birth was created with follow-up of infection status. The register included children born to HIV-infected women between 1 January 2001 and 31 December 2003 at 84 public health hospitals in six provinces of Thailand. The main outcome measure was HIV infection in children. RESULTS: A total of 2200 children born to HIV-infected mothers were registered. Of these mother-infant pairs, 2105 (95.7%) received some antiretroviral prophylaxis, including 1358 (61.7%) who received the complete short-course zidovudine regimen during pregnancy and labor for the mother and after birth for the infant, with or without other antiretrovirals. HIV infection outcome was determined for 1667 (75.8%) children, of whom 158 [9.5%, 95% confidence interval (CI), 8.1-11.0%] were infected. Transmission risk was 6.8% (95% CI 5.2-8.9%) among 761 mother-infant pairs that received the complete zidovudine regimen alone, and 3.9% (95% CI, 2.2-6.6%) among 361 mother-infant pairs that received the complete zidovudine regimen combined with other antiretrovirals, usually nevirapine. The overall transmission risk from this cohort, including all antiretroviral prophylaxis combinations, is estimated to be 10.2%. CONCLUSIONS: The Thai national PMTCT program is effective in reducing mother-to-child transmission risk from the historical risk of 18.9-24.2%. The addition of nevirapine to short-course zidovudine beginning in 2004 may further improve program effectiveness in Thailand. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/17197804/Reduction_in_mother_to_child_transmission_of_HIV_in_Thailand_2001_2003:_Results_from_population_based_surveillance_in_six_provinces_ L2 - http://Insights.ovid.com/pubmed?pmid=17197804 DB - PRIME DP - Unbound Medicine ER -