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Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree.
Am J Vet Res. 2007 Jan; 68(1):35-41.AJ

Abstract

OBJECTIVE

To evaluate the quantitative inheritance of secondary hip joint osteoarthritis in a canine pedigree.

ANIMALS

137 Labrador Retrievers, Greyhounds, and mixed-breed dogs.

PROCEDURES

Necropsy scores ranging from 0 to 4 were obtained for each hip joint. Seven unaffected Greyhounds with normal hip joint conformation were also used for genetic modeling, but were not euthanized. Sixty-six male and 71 female dogs were allocated to 2 groups (< or = 12 months of age and > 12 months of age). Statistical models were developed to establish the inheritance pattern of hip joint osteoarthritis that developed secondary to hip dysplasia.

RESULTS

62 dogs had evidence of osteoarthritis in a hip joint, and 75 had no evidence of osteoarthritis. After sex was adjusted for, the necropsy score was found to be inherited additively but without dominance. Each Labrador Retriever allele increased the necropsy score by 0.7 to 0.9 points, compared with the Greyhound allele, and male sex increased the necropsy score 0.74 over female sex. Approximately 10% of the variation in necropsy score was attributable to the litter of puppies' origin.

CONCLUSIONS AND CLINICAL RELEVANCE

Because secondary hip joint osteoarthritis is inherited additively, selection pressure could be applied to reduce its incidence. Similar statistical models can be used in linkage and association mapping to detect the genes in the underlying quantitative trait loci that contribute to hip joint osteoarthritis.

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Authors+Show Affiliations

Hays L
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Zhang Z
No affiliation info available
Mateescu RG
No affiliation info available
Lust G
No affiliation info available
Burton-Wurster NI
No affiliation info available
Todhunter RJ
No affiliation info available

MeSH

Age FactorsAnimalsCrosses, GeneticDogsFemaleGenetic LinkageGenotypeHip Dysplasia, CanineMaleModels, GeneticOsteoarthritis, HipPedigreeQuantitative Trait LociSex Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17199416

Citation

Hays, Laurel, et al. "Quantitative Genetics of Secondary Hip Joint Osteoarthritis in a Labrador Retriever-Greyhound Pedigree." American Journal of Veterinary Research, vol. 68, no. 1, 2007, pp. 35-41.
Hays L, Zhang Z, Mateescu RG, et al. Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree. Am J Vet Res. 2007;68(1):35-41.
Hays, L., Zhang, Z., Mateescu, R. G., Lust, G., Burton-Wurster, N. I., & Todhunter, R. J. (2007). Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree. American Journal of Veterinary Research, 68(1), 35-41.
Hays L, et al. Quantitative Genetics of Secondary Hip Joint Osteoarthritis in a Labrador Retriever-Greyhound Pedigree. Am J Vet Res. 2007;68(1):35-41. PubMed PMID: 17199416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree. AU - Hays,Laurel, AU - Zhang,Zhiwu, AU - Mateescu,Raluca G, AU - Lust,George, AU - Burton-Wurster,Nancy I, AU - Todhunter,Rory J, PY - 2007/1/4/pubmed PY - 2007/3/23/medline PY - 2007/1/4/entrez SP - 35 EP - 41 JF - American journal of veterinary research JO - Am J Vet Res VL - 68 IS - 1 N2 - OBJECTIVE: To evaluate the quantitative inheritance of secondary hip joint osteoarthritis in a canine pedigree. ANIMALS: 137 Labrador Retrievers, Greyhounds, and mixed-breed dogs. PROCEDURES: Necropsy scores ranging from 0 to 4 were obtained for each hip joint. Seven unaffected Greyhounds with normal hip joint conformation were also used for genetic modeling, but were not euthanized. Sixty-six male and 71 female dogs were allocated to 2 groups (< or = 12 months of age and > 12 months of age). Statistical models were developed to establish the inheritance pattern of hip joint osteoarthritis that developed secondary to hip dysplasia. RESULTS: 62 dogs had evidence of osteoarthritis in a hip joint, and 75 had no evidence of osteoarthritis. After sex was adjusted for, the necropsy score was found to be inherited additively but without dominance. Each Labrador Retriever allele increased the necropsy score by 0.7 to 0.9 points, compared with the Greyhound allele, and male sex increased the necropsy score 0.74 over female sex. Approximately 10% of the variation in necropsy score was attributable to the litter of puppies' origin. CONCLUSIONS AND CLINICAL RELEVANCE: Because secondary hip joint osteoarthritis is inherited additively, selection pressure could be applied to reduce its incidence. Similar statistical models can be used in linkage and association mapping to detect the genes in the underlying quantitative trait loci that contribute to hip joint osteoarthritis. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/17199416/Quantitative_genetics_of_secondary_hip_joint_osteoarthritis_in_a_Labrador_Retriever_Greyhound_pedigree_ L2 - https://avmajournals.avma.org/doi/10.2460/ajvr.68.1.35?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -