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Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways.
Auton Autacoid Pharmacol. 2007 Jan; 27(1):39-46.AA

Abstract

1. The effect of montelukast or MEN91507, selective leucotriene CysLT1 receptor antagonists, on antigen-induced airway inflammation and bronchoconstriction were compared in anaesthetized guinea-pigs. 2. In sensitized animals, ovalbumin (0.3 mg kg(-1), i.v.)-induced microvascular leakage in trachea, intrapulmonary airways, total lung (parenchyma and intrapulmonary airways) and urinary bladder was reduced by MEN91507 (0.01-1 micromol kg(-1), i.v.), whereas montelukast (0.01-1 micromol kg(-1), i.v.) antagonized the effect of the antigen only in the lung and urinary bladder. 3. Ovalbumin (1 mg kg(-1), i.v.)-induced bronchoconstriction was dose dependently antagonized by MEN91507 (10-30 micromol kg(-1), i.v.), whereas the effect of montelukast (0.1-30 micromol kg(-1), i.v.) was marginal (15-30% inhibition). Neither MEN91507 nor montelukast (30 micromol kg(-1), i.v.) affected the bronchoconstrictor response induced by acetylcholine (0.3 micromol kg(-1), i.v.) in sensitized animals. 4. It is concluded that montelukast and MEN91507 display a differential activity against the effect of endogenous leucotrienes, despite the fact that both compounds show a similar antagonist profile against exogenous leucotrienes acting through CysLT1 receptors.

Authors+Show Affiliations

Department of Pharmacology, School of Pharmacy, Central University of Venezuela, Caracas, Venezuela.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17199874

Citation

Alfieri, A B., et al. "Heterogeneous Effect of Leucotriene CysLT1 Receptor Antagonists On Antigen-induced Motor and Inflammatory Responses in Guinea-pig Airways." Autonomic & Autacoid Pharmacology, vol. 27, no. 1, 2007, pp. 39-46.
Alfieri AB, Tramontana M, Cialdai C, et al. Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways. Auton Autacoid Pharmacol. 2007;27(1):39-46.
Alfieri, A. B., Tramontana, M., Cialdai, C., Lecci, A., Giuliani, S., Crea, A., Manzini, S., & Maggi, C. A. (2007). Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways. Autonomic & Autacoid Pharmacology, 27(1), 39-46.
Alfieri AB, et al. Heterogeneous Effect of Leucotriene CysLT1 Receptor Antagonists On Antigen-induced Motor and Inflammatory Responses in Guinea-pig Airways. Auton Autacoid Pharmacol. 2007;27(1):39-46. PubMed PMID: 17199874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways. AU - Alfieri,A B, AU - Tramontana,M, AU - Cialdai,C, AU - Lecci,A, AU - Giuliani,S, AU - Crea,A, AU - Manzini,S, AU - Maggi,C A, PY - 2007/1/4/pubmed PY - 2007/4/25/medline PY - 2007/1/4/entrez SP - 39 EP - 46 JF - Autonomic & autacoid pharmacology JO - Auton Autacoid Pharmacol VL - 27 IS - 1 N2 - 1. The effect of montelukast or MEN91507, selective leucotriene CysLT1 receptor antagonists, on antigen-induced airway inflammation and bronchoconstriction were compared in anaesthetized guinea-pigs. 2. In sensitized animals, ovalbumin (0.3 mg kg(-1), i.v.)-induced microvascular leakage in trachea, intrapulmonary airways, total lung (parenchyma and intrapulmonary airways) and urinary bladder was reduced by MEN91507 (0.01-1 micromol kg(-1), i.v.), whereas montelukast (0.01-1 micromol kg(-1), i.v.) antagonized the effect of the antigen only in the lung and urinary bladder. 3. Ovalbumin (1 mg kg(-1), i.v.)-induced bronchoconstriction was dose dependently antagonized by MEN91507 (10-30 micromol kg(-1), i.v.), whereas the effect of montelukast (0.1-30 micromol kg(-1), i.v.) was marginal (15-30% inhibition). Neither MEN91507 nor montelukast (30 micromol kg(-1), i.v.) affected the bronchoconstrictor response induced by acetylcholine (0.3 micromol kg(-1), i.v.) in sensitized animals. 4. It is concluded that montelukast and MEN91507 display a differential activity against the effect of endogenous leucotrienes, despite the fact that both compounds show a similar antagonist profile against exogenous leucotrienes acting through CysLT1 receptors. SN - 1474-8665 UR - https://www.unboundmedicine.com/medline/citation/17199874/Heterogeneous_effect_of_leucotriene_CysLT1_receptor_antagonists_on_antigen_induced_motor_and_inflammatory_responses_in_guinea_pig_airways_ L2 - https://doi.org/10.1111/j.1474-8673.2006.00388.x DB - PRIME DP - Unbound Medicine ER -