Tags

Type your tag names separated by a space and hit enter

Sex differences in clinical predictors of suicidal acts after major depression: a prospective study.
Am J Psychiatry. 2007 Jan; 164(1):134-41.AJ

Abstract

OBJECTIVE

Whether sex differences exist in clinical risk factors associated with suicidal behavior is unknown. The authors postulated that among men with a major depressive episode, aggression, hostility, and history of substance misuse increase risk for future suicidal behavior, while depressive symptoms, childhood history of abuse, fewer reasons for living, and borderline personality disorder do so in depressed women.

METHOD

Patients with DSM-III-R major depression or bipolar disorder seeking treatment for a major depressive episode (N=314) were followed for 2 years. Putative predictors were tested with Cox proportional hazards regression analysis.

RESULTS

During follow-up, 16.6% of the patients attempted or committed suicide. Family history of suicidal acts, past drug use, cigarette smoking, borderline personality disorder, and early parental separation each more than tripled the risk of future suicidal acts in men. For women, the risk for future suicidal acts was sixfold greater for prior suicide attempters; each past attempt increased future risk threefold. Suicidal ideation, lethality of past attempts, hostility, subjective depressive symptoms, fewer reasons for living, comorbid borderline personality disorder, and cigarette smoking also increased the risk of future suicidal acts for women.

CONCLUSIONS

These findings suggest that the importance of risk factors for suicidal acts differs in depressed men and women. This knowledge may improve suicide risk evaluation and guide future research on suicide assessment and prevention.

Links

PMC Free PDF
PMC Free Full Text
Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Oquendo MA
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, 1051 Riverside Dr., New York, NY 10032, USA. moquendo@neuron.cpmc.columbia.edu
Bongiovi-Garcia ME
No affiliation info available
Galfalvy H
No affiliation info available
Goldberg PH
No affiliation info available
Grunebaum MF
No affiliation info available
Burke AK
No affiliation info available
Mann JJ
No affiliation info available

MeSH

AdolescentAdultAgedBorderline Personality DisorderChildChild AbuseComorbidityDepressive Disorder, MajorDiagnosis, Dual (Psychiatry)FemaleHumansMaleMiddle AgedPrognosisProspective StudiesPsychiatric Status Rating ScalesRisk FactorsSex FactorsSmokingSubstance-Related DisordersSuicideSuicide, Attempted

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17202555

Citation

Oquendo, Maria A., et al. "Sex Differences in Clinical Predictors of Suicidal Acts After Major Depression: a Prospective Study." The American Journal of Psychiatry, vol. 164, no. 1, 2007, pp. 134-41.
Oquendo MA, Bongiovi-Garcia ME, Galfalvy H, et al. Sex differences in clinical predictors of suicidal acts after major depression: a prospective study. Am J Psychiatry. 2007;164(1):134-41.
Oquendo, M. A., Bongiovi-Garcia, M. E., Galfalvy, H., Goldberg, P. H., Grunebaum, M. F., Burke, A. K., & Mann, J. J. (2007). Sex differences in clinical predictors of suicidal acts after major depression: a prospective study. The American Journal of Psychiatry, 164(1), 134-41.
Oquendo MA, et al. Sex Differences in Clinical Predictors of Suicidal Acts After Major Depression: a Prospective Study. Am J Psychiatry. 2007;164(1):134-41. PubMed PMID: 17202555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex differences in clinical predictors of suicidal acts after major depression: a prospective study. AU - Oquendo,Maria A, AU - Bongiovi-Garcia,Mary E, AU - Galfalvy,Hanga, AU - Goldberg,Pablo H, AU - Grunebaum,Michael F, AU - Burke,Ainsley K, AU - Mann,J John, PY - 2007/1/5/pubmed PY - 2007/3/14/medline PY - 2007/1/5/entrez SP - 134 EP - 41 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 164 IS - 1 N2 - OBJECTIVE: Whether sex differences exist in clinical risk factors associated with suicidal behavior is unknown. The authors postulated that among men with a major depressive episode, aggression, hostility, and history of substance misuse increase risk for future suicidal behavior, while depressive symptoms, childhood history of abuse, fewer reasons for living, and borderline personality disorder do so in depressed women. METHOD: Patients with DSM-III-R major depression or bipolar disorder seeking treatment for a major depressive episode (N=314) were followed for 2 years. Putative predictors were tested with Cox proportional hazards regression analysis. RESULTS: During follow-up, 16.6% of the patients attempted or committed suicide. Family history of suicidal acts, past drug use, cigarette smoking, borderline personality disorder, and early parental separation each more than tripled the risk of future suicidal acts in men. For women, the risk for future suicidal acts was sixfold greater for prior suicide attempters; each past attempt increased future risk threefold. Suicidal ideation, lethality of past attempts, hostility, subjective depressive symptoms, fewer reasons for living, comorbid borderline personality disorder, and cigarette smoking also increased the risk of future suicidal acts for women. CONCLUSIONS: These findings suggest that the importance of risk factors for suicidal acts differs in depressed men and women. This knowledge may improve suicide risk evaluation and guide future research on suicide assessment and prevention. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/17202555/Sex_differences_in_clinical_predictors_of_suicidal_acts_after_major_depression:_a_prospective_study_ L2 - https://ajp.psychiatryonline.org/doi/10.1176/ajp.2007.164.1.134?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -