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The additive effects of minoxidil and retinol on human hair growth in vitro.
Biol Pharm Bull. 2007 Jan; 30(1):21-6.BP

Abstract

Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT. We found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.

Authors+Show Affiliations

Department of Dermatology, Seoul National University College of Medicine, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17202653

Citation

Yoo, Hyeon Gyeong, et al. "The Additive Effects of Minoxidil and Retinol On Human Hair Growth in Vitro." Biological & Pharmaceutical Bulletin, vol. 30, no. 1, 2007, pp. 21-6.
Yoo HG, Chang IY, Pyo HK, et al. The additive effects of minoxidil and retinol on human hair growth in vitro. Biol Pharm Bull. 2007;30(1):21-6.
Yoo, H. G., Chang, I. Y., Pyo, H. K., Kang, Y. J., Lee, S. H., Kwon, O. S., Cho, K. H., Eun, H. C., & Kim, K. H. (2007). The additive effects of minoxidil and retinol on human hair growth in vitro. Biological & Pharmaceutical Bulletin, 30(1), 21-6.
Yoo HG, et al. The Additive Effects of Minoxidil and Retinol On Human Hair Growth in Vitro. Biol Pharm Bull. 2007;30(1):21-6. PubMed PMID: 17202653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The additive effects of minoxidil and retinol on human hair growth in vitro. AU - Yoo,Hyeon Gyeong, AU - Chang,In-Young, AU - Pyo,Hyun Keol, AU - Kang,Yong Jung, AU - Lee,Seung Ho, AU - Kwon,Oh Sang, AU - Cho,Kwang Hyun, AU - Eun,Hee Chul, AU - Kim,Kyu Han, PY - 2007/1/5/pubmed PY - 2007/3/14/medline PY - 2007/1/5/entrez SP - 21 EP - 6 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 30 IS - 1 N2 - Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT. We found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/17202653/The_additive_effects_of_minoxidil_and_retinol_on_human_hair_growth_in_vitro_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/30.21?from=PubMed DB - PRIME DP - Unbound Medicine ER -