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Nasopharyngeal carriage of respiratory pathogens in children undergoing pressure equalization tube placement in the era of pneumococcal protein conjugate vaccine use.
Laryngoscope. 2007 Feb; 117(2):295-8.L

Abstract

OBJECTIVE

To define carriage of bacterial respiratory pathogens in children undergoing pressure equalization tube placement.

STUDY DESIGN

Nasopharyngeal cultures were performed during tube placement. Antibiotic susceptibilities and serotypes of pneumococci were determined.

RESULTS

Sixty-nine Streptococcus pneumoniae, 72 Haemophilus influenzae (41% beta-lactamase positive), and 39 Moraxella catarrhalis (all beta-lactamase positive) were isolated from 201 children. Overall, 42% of pneumococci were nonsusceptible to penicillin, and 34.8% were resistant to macrolides. In relation to the pneumococcal conjugate vaccine, 17.4% were vaccine, 31.9% vaccine-related, and 50.7% nonvaccine serotypes.

CONCLUSION

Twenty-five percent of children colonized with pneumococci carried antibiotic resistant nonvaccine serotypes rarely detected before the introduction of pneumococcal conjugate vaccine, including serotype 19A isolates (7%) resistant to all oral agents tested and type 35B isolates (12%) nonsusceptible to penicillin and cefuroxime.

SIGNIFICANCE

Pneumococcal colonization suggests replacement of vaccine serotypes with vaccine related and nonvaccine serotypes, many of which are resistant to common oral antimicrobials.

Authors+Show Affiliations

Department of Pathology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. mrj6@po.cwru.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17202908

Citation

Jacobs, Michael R., et al. "Nasopharyngeal Carriage of Respiratory Pathogens in Children Undergoing Pressure Equalization Tube Placement in the Era of Pneumococcal Protein Conjugate Vaccine Use." The Laryngoscope, vol. 117, no. 2, 2007, pp. 295-8.
Jacobs MR, Good CE, Sellner T, et al. Nasopharyngeal carriage of respiratory pathogens in children undergoing pressure equalization tube placement in the era of pneumococcal protein conjugate vaccine use. Laryngoscope. 2007;117(2):295-8.
Jacobs, M. R., Good, C. E., Sellner, T., Bajaksouzian, S., Windau, A., & Anon, J. B. (2007). Nasopharyngeal carriage of respiratory pathogens in children undergoing pressure equalization tube placement in the era of pneumococcal protein conjugate vaccine use. The Laryngoscope, 117(2), 295-8.
Jacobs MR, et al. Nasopharyngeal Carriage of Respiratory Pathogens in Children Undergoing Pressure Equalization Tube Placement in the Era of Pneumococcal Protein Conjugate Vaccine Use. Laryngoscope. 2007;117(2):295-8. PubMed PMID: 17202908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasopharyngeal carriage of respiratory pathogens in children undergoing pressure equalization tube placement in the era of pneumococcal protein conjugate vaccine use. AU - Jacobs,Michael R, AU - Good,Caryn E, AU - Sellner,Tom, AU - Bajaksouzian,Saralee, AU - Windau,Anne, AU - Anon,Jack B, PY - 2007/1/5/pubmed PY - 2007/3/21/medline PY - 2007/1/5/entrez SP - 295 EP - 8 JF - The Laryngoscope JO - Laryngoscope VL - 117 IS - 2 N2 - OBJECTIVE: To define carriage of bacterial respiratory pathogens in children undergoing pressure equalization tube placement. STUDY DESIGN: Nasopharyngeal cultures were performed during tube placement. Antibiotic susceptibilities and serotypes of pneumococci were determined. RESULTS: Sixty-nine Streptococcus pneumoniae, 72 Haemophilus influenzae (41% beta-lactamase positive), and 39 Moraxella catarrhalis (all beta-lactamase positive) were isolated from 201 children. Overall, 42% of pneumococci were nonsusceptible to penicillin, and 34.8% were resistant to macrolides. In relation to the pneumococcal conjugate vaccine, 17.4% were vaccine, 31.9% vaccine-related, and 50.7% nonvaccine serotypes. CONCLUSION: Twenty-five percent of children colonized with pneumococci carried antibiotic resistant nonvaccine serotypes rarely detected before the introduction of pneumococcal conjugate vaccine, including serotype 19A isolates (7%) resistant to all oral agents tested and type 35B isolates (12%) nonsusceptible to penicillin and cefuroxime. SIGNIFICANCE: Pneumococcal colonization suggests replacement of vaccine serotypes with vaccine related and nonvaccine serotypes, many of which are resistant to common oral antimicrobials. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/17202908/Nasopharyngeal_carriage_of_respiratory_pathogens_in_children_undergoing_pressure_equalization_tube_placement_in_the_era_of_pneumococcal_protein_conjugate_vaccine_use_ L2 - https://doi.org/10.1097/01.mlg.0000250490.49183.84 DB - PRIME DP - Unbound Medicine ER -