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Association of cognitive impairment with plasma levels of folate, vitamin B12 and homocysteine in the elderly.
In Vivo. 2006 Nov-Dec; 20(6B):895-9.V

Abstract

BACKGROUND

Alterations in folate, vitamin B12 and homocysteine plasma levels have been associated with aging, neuronal development and cognitive impairment. The aim of this study was to investigate the relationship between plasma folate, vitamin B12 and homocysteine and cognitive function in the elderly.

PATIENTS AND METHODS

Elderly individuals over 60 years of age living in the community, were screened with the Mini-Mental State Examination. The study population was divided into two groups: (a) 37 subjects with dementia; and (b) 33 healthy controls. Blood samples were analyzed with the use of ELISA, and the results were statistically evaluated at p < 0.05 level of significance.

RESULTS

Group a had significantly lower levels of folate and vitamin B12 than group b. Homocysteine was significantly higher in demented individuals than in controls (p < 0.01).

CONCLUSION

Lower levels of plasma folate and/or vitamin B12 and higher levels of plasma homocysteine are associated with cognitive impairment in elderly individuals.

Authors+Show Affiliations

Department of Biological Chemistry, Medical School of Athens University 75 M. Asias St., Athens, Greece. dmpnikos@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17203786

Citation

Dimopoulos, Nikolaos, et al. "Association of Cognitive Impairment With Plasma Levels of Folate, Vitamin B12 and Homocysteine in the Elderly." In Vivo (Athens, Greece), vol. 20, no. 6B, 2006, pp. 895-9.
Dimopoulos N, Piperi C, Salonicioti A, et al. Association of cognitive impairment with plasma levels of folate, vitamin B12 and homocysteine in the elderly. In Vivo. 2006;20(6B):895-9.
Dimopoulos, N., Piperi, C., Salonicioti, A., Psarra, V., Gazi, F., Nounopoulos, C., Lea, R. W., & Kalofoutis, A. (2006). Association of cognitive impairment with plasma levels of folate, vitamin B12 and homocysteine in the elderly. In Vivo (Athens, Greece), 20(6B), 895-9.
Dimopoulos N, et al. Association of Cognitive Impairment With Plasma Levels of Folate, Vitamin B12 and Homocysteine in the Elderly. In Vivo. 2006 Nov-Dec;20(6B):895-9. PubMed PMID: 17203786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of cognitive impairment with plasma levels of folate, vitamin B12 and homocysteine in the elderly. AU - Dimopoulos,Nikolaos, AU - Piperi,Christina, AU - Salonicioti,Aristea, AU - Psarra,Vassiliki, AU - Gazi,Flerri, AU - Nounopoulos,Charalambos, AU - Lea,Robert W, AU - Kalofoutis,Anastasios, PY - 2007/1/6/pubmed PY - 2007/2/6/medline PY - 2007/1/6/entrez SP - 895 EP - 9 JF - In vivo (Athens, Greece) JO - In Vivo VL - 20 IS - 6B N2 - BACKGROUND: Alterations in folate, vitamin B12 and homocysteine plasma levels have been associated with aging, neuronal development and cognitive impairment. The aim of this study was to investigate the relationship between plasma folate, vitamin B12 and homocysteine and cognitive function in the elderly. PATIENTS AND METHODS: Elderly individuals over 60 years of age living in the community, were screened with the Mini-Mental State Examination. The study population was divided into two groups: (a) 37 subjects with dementia; and (b) 33 healthy controls. Blood samples were analyzed with the use of ELISA, and the results were statistically evaluated at p < 0.05 level of significance. RESULTS: Group a had significantly lower levels of folate and vitamin B12 than group b. Homocysteine was significantly higher in demented individuals than in controls (p < 0.01). CONCLUSION: Lower levels of plasma folate and/or vitamin B12 and higher levels of plasma homocysteine are associated with cognitive impairment in elderly individuals. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/17203786/Association_of_cognitive_impairment_with_plasma_levels_of_folate_vitamin_B12_and_homocysteine_in_the_elderly_ L2 - http://iv.iiarjournals.org/cgi/pmidlookup?view=long&amp;pmid=17203786 DB - PRIME DP - Unbound Medicine ER -