Tags

Type your tag names separated by a space and hit enter

Physicochemical and microbiological properties of eye drops containing cefuroxime.
Acta Pol Pharm. 2006 Jul-Aug; 63(4):293-9.AP

Abstract

The purpose of the studies was to examine the influence of the additives and storage temperature on physicochemical properties and on the antimicrobial activity of cefuroxime in the eye drops. The eye drops were 1% sterile aqueous solutions of cefuroxime in citrate buffer of pH 6.15-6.20, preserved with 0.002% thiomersal or 0.001% phenylmercuric borate with 0.4% beta-phenylethyl alcohol. Viscosity of the eye drops was increased using polyvinyl alcohol. The drops, protected from light, were stored at the temperature of 4 degrees C and 20 degrees C. As the criteria of the qualitative assessment of freshly prepared eye drops and during their storage, the following properties were considered: organoleptic analysis (color, clarity, and smell), sterility, pH, osmotic pressure, density, and viscosity, antimicrobial activity of cefuroxime and preservation efficiency of thiomersal and phenylmercuric borate in the eye drops. The storage temperature had a significant influence on the antimicrobial activity of the antibiotic in the eye drops. The antimicrobial activity of cefuroxime in the drops stored for 30 days at the temperature of 4 degrees C did not decrease. Thiomersal at the concentration over 0.003%, 0.005% benzalkonium chloride and 0.01% chlorhexidine diacetate were not compatible with cefuroxime in the drops.

Authors+Show Affiliations

Department of Drug Form Technology, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17203867

Citation

Kodym, Anna, et al. "Physicochemical and Microbiological Properties of Eye Drops Containing Cefuroxime." Acta Poloniae Pharmaceutica, vol. 63, no. 4, 2006, pp. 293-9.
Kodym A, Zawisza T, Taberska J, et al. Physicochemical and microbiological properties of eye drops containing cefuroxime. Acta Pol Pharm. 2006;63(4):293-9.
Kodym, A., Zawisza, T., Taberska, J., & Kukuła, H. (2006). Physicochemical and microbiological properties of eye drops containing cefuroxime. Acta Poloniae Pharmaceutica, 63(4), 293-9.
Kodym A, et al. Physicochemical and Microbiological Properties of Eye Drops Containing Cefuroxime. Acta Pol Pharm. 2006 Jul-Aug;63(4):293-9. PubMed PMID: 17203867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physicochemical and microbiological properties of eye drops containing cefuroxime. AU - Kodym,Anna, AU - Zawisza,Tomasz, AU - Taberska,Joanna, AU - Kukuła,Helena, PY - 2007/1/6/pubmed PY - 2007/2/3/medline PY - 2007/1/6/entrez SP - 293 EP - 9 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 63 IS - 4 N2 - The purpose of the studies was to examine the influence of the additives and storage temperature on physicochemical properties and on the antimicrobial activity of cefuroxime in the eye drops. The eye drops were 1% sterile aqueous solutions of cefuroxime in citrate buffer of pH 6.15-6.20, preserved with 0.002% thiomersal or 0.001% phenylmercuric borate with 0.4% beta-phenylethyl alcohol. Viscosity of the eye drops was increased using polyvinyl alcohol. The drops, protected from light, were stored at the temperature of 4 degrees C and 20 degrees C. As the criteria of the qualitative assessment of freshly prepared eye drops and during their storage, the following properties were considered: organoleptic analysis (color, clarity, and smell), sterility, pH, osmotic pressure, density, and viscosity, antimicrobial activity of cefuroxime and preservation efficiency of thiomersal and phenylmercuric borate in the eye drops. The storage temperature had a significant influence on the antimicrobial activity of the antibiotic in the eye drops. The antimicrobial activity of cefuroxime in the drops stored for 30 days at the temperature of 4 degrees C did not decrease. Thiomersal at the concentration over 0.003%, 0.005% benzalkonium chloride and 0.01% chlorhexidine diacetate were not compatible with cefuroxime in the drops. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/17203867/Physicochemical_and_microbiological_properties_of_eye_drops_containing_cefuroxime_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2006/4/293.pdf DB - PRIME DP - Unbound Medicine ER -