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Electrochemical quartz crystal impedance study on the overoxidation of polypyrrole-carbon nanotubes composite film for amperometric detection of dopamine.
Biosens Bioelectron. 2007 Jun 15; 22(12):2819-26.BB

Abstract

The electrochemical quartz crystal impedance (EQCI) method was used to study the overoxidation of polypyrrole (PPy)-multiwalled carbon nanotubes (MWCNT) nanocomposite film in neutral and alkaline solutions. The values of molar mass per electron transferred (M/n) obtained during the overoxidation of PPy in 0.10 mol L(-1) Na(2)SO(4) and 0.20 mol L(-1) NaOH aqueous solutions were estimated to be ca. 17 and 22 g mol(-1), respectively, suggesting the nucleophilic attack of solution OH(-) to the pyrrole units during the overoxidation, and the possible partial formation of carboxylic groups after the overoxidation in the NaOH solution. Also, the overoxidized PPy-MWCNT composite film prepared in the NaOH solution showed a notably larger affinity to dopamine (DA) dissolved in a neutral phosphate buffer than that prepared in the Na(2)SO(4) solution. The modification of the overoxidized nanocomposite film improved substantially the sensitivity for DA assay in a neutral phosphate buffer, as compared with the modification of overoxidized PPy or MWCNT alone. At a -6 kHz (201-nm thickness) nanocomposite film prepared in a polymerization bath containing 1.0 mg mL(-1) MWCNT and overoxidized in 0.20 mol L(-1) aqueous NaOH, the peak current response from differential pulse voltammetric assay of DA was linear with DA concentration from 4.0 x 10(-8) to 1.4 x 10(-6) mol L(-1), with a lower limit of detection of 1.7 nmol L(-1), good anti-interferent ability, as well as good stability and reproducibility.

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Authors+Show Affiliations

Tu X
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.
Xie Q
No affiliation info available
Jiang S
No affiliation info available
Yao S
No affiliation info available

MeSH

Biosensing TechniquesCatalysisDopamineElectric ImpedanceElectrochemistryNanotubes, CarbonOxidation-ReductionPolymersPyrrolesQuartz

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17204412

Citation

Tu, Xinman, et al. "Electrochemical Quartz Crystal Impedance Study On the Overoxidation of Polypyrrole-carbon Nanotubes Composite Film for Amperometric Detection of Dopamine." Biosensors & Bioelectronics, vol. 22, no. 12, 2007, pp. 2819-26.
Tu X, Xie Q, Jiang S, et al. Electrochemical quartz crystal impedance study on the overoxidation of polypyrrole-carbon nanotubes composite film for amperometric detection of dopamine. Biosens Bioelectron. 2007;22(12):2819-26.
Tu, X., Xie, Q., Jiang, S., & Yao, S. (2007). Electrochemical quartz crystal impedance study on the overoxidation of polypyrrole-carbon nanotubes composite film for amperometric detection of dopamine. Biosensors & Bioelectronics, 22(12), 2819-26.
Tu X, et al. Electrochemical Quartz Crystal Impedance Study On the Overoxidation of Polypyrrole-carbon Nanotubes Composite Film for Amperometric Detection of Dopamine. Biosens Bioelectron. 2007 Jun 15;22(12):2819-26. PubMed PMID: 17204412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical quartz crystal impedance study on the overoxidation of polypyrrole-carbon nanotubes composite film for amperometric detection of dopamine. AU - Tu,Xinman, AU - Xie,Qingji, AU - Jiang,Shiyu, AU - Yao,Shouzhuo, Y1 - 2007/01/03/ PY - 2006/05/29/received PY - 2006/11/16/revised PY - 2006/11/21/accepted PY - 2007/1/6/pubmed PY - 2007/7/27/medline PY - 2007/1/6/entrez SP - 2819 EP - 26 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 22 IS - 12 N2 - The electrochemical quartz crystal impedance (EQCI) method was used to study the overoxidation of polypyrrole (PPy)-multiwalled carbon nanotubes (MWCNT) nanocomposite film in neutral and alkaline solutions. The values of molar mass per electron transferred (M/n) obtained during the overoxidation of PPy in 0.10 mol L(-1) Na(2)SO(4) and 0.20 mol L(-1) NaOH aqueous solutions were estimated to be ca. 17 and 22 g mol(-1), respectively, suggesting the nucleophilic attack of solution OH(-) to the pyrrole units during the overoxidation, and the possible partial formation of carboxylic groups after the overoxidation in the NaOH solution. Also, the overoxidized PPy-MWCNT composite film prepared in the NaOH solution showed a notably larger affinity to dopamine (DA) dissolved in a neutral phosphate buffer than that prepared in the Na(2)SO(4) solution. The modification of the overoxidized nanocomposite film improved substantially the sensitivity for DA assay in a neutral phosphate buffer, as compared with the modification of overoxidized PPy or MWCNT alone. At a -6 kHz (201-nm thickness) nanocomposite film prepared in a polymerization bath containing 1.0 mg mL(-1) MWCNT and overoxidized in 0.20 mol L(-1) aqueous NaOH, the peak current response from differential pulse voltammetric assay of DA was linear with DA concentration from 4.0 x 10(-8) to 1.4 x 10(-6) mol L(-1), with a lower limit of detection of 1.7 nmol L(-1), good anti-interferent ability, as well as good stability and reproducibility. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/17204412/Electrochemical_quartz_crystal_impedance_study_on_the_overoxidation_of_polypyrrole_carbon_nanotubes_composite_film_for_amperometric_detection_of_dopamine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(06)00560-4 DB - PRIME DP - Unbound Medicine ER -