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Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis.
Biometals. 2007 Jun; 20(3-4):549-64.B

Abstract

Iron and citrate are essential for the metabolism of most organisms, and regulation of iron and citrate biology at both the cellular and systemic levels is critical for normal physiology and survival. Mitochondrial and cytosolic aconitases catalyze the interconversion of citrate and isocitrate, and aconitase activities are affected by iron levels, oxidative stress and by the status of the Fe-S cluster biogenesis apparatus. Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1). This review discusses the central role of aconitases in intermediary metabolism and explores how iron homeostasis and Fe-S cluster biogenesis regulate the Fe-S cluster switch and modulate intracellular citrate flux.

Authors+Show Affiliations

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, NIH Bldg 18, Rm 101, Bethesda, MD 20892, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17205209

Citation

Tong, Wing-Hang, and Tracey A. Rouault. "Metabolic Regulation of Citrate and Iron By Aconitases: Role of Iron-sulfur Cluster Biogenesis." Biometals : an International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 20, no. 3-4, 2007, pp. 549-64.
Tong WH, Rouault TA. Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis. Biometals. 2007;20(3-4):549-64.
Tong, W. H., & Rouault, T. A. (2007). Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis. Biometals : an International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine, 20(3-4), 549-64.
Tong WH, Rouault TA. Metabolic Regulation of Citrate and Iron By Aconitases: Role of Iron-sulfur Cluster Biogenesis. Biometals. 2007;20(3-4):549-64. PubMed PMID: 17205209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis. AU - Tong,Wing-Hang, AU - Rouault,Tracey A, Y1 - 2007/01/05/ PY - 2006/07/11/received PY - 2006/11/28/accepted PY - 2007/1/6/pubmed PY - 2007/8/29/medline PY - 2007/1/6/entrez SP - 549 EP - 64 JF - Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine JO - Biometals VL - 20 IS - 3-4 N2 - Iron and citrate are essential for the metabolism of most organisms, and regulation of iron and citrate biology at both the cellular and systemic levels is critical for normal physiology and survival. Mitochondrial and cytosolic aconitases catalyze the interconversion of citrate and isocitrate, and aconitase activities are affected by iron levels, oxidative stress and by the status of the Fe-S cluster biogenesis apparatus. Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1). This review discusses the central role of aconitases in intermediary metabolism and explores how iron homeostasis and Fe-S cluster biogenesis regulate the Fe-S cluster switch and modulate intracellular citrate flux. SN - 0966-0844 UR - https://www.unboundmedicine.com/medline/citation/17205209/Metabolic_regulation_of_citrate_and_iron_by_aconitases:_role_of_iron_sulfur_cluster_biogenesis_ DB - PRIME DP - Unbound Medicine ER -