Tags

Type your tag names separated by a space and hit enter

Diagnostic yield of routine duodenal biopsies in iron deficiency anaemia: a study from Western Anatolia.
Eur J Gastroenterol Hepatol. 2007 Jan; 19(1):37-41.EJ

Abstract

OBJECTIVE

The role of routine endoscopic duodenal biopsies obtained during the evaluation of iron deficiency anaemia is being increasingly emphasized, but insufficiently applied. Diagnostic yield of this practice, mainly identification of coeliac disease, differs in different populations and geographic regions. The aim of this study is to assess the usefulness of routine duodenal biopsies during upper endoscopy in patients presenting with iron deficiency anaemia in Western Anatolia.

METHODS

Routine duodenal biopsies were evaluated over a 12-month period in 100 consecutive adult patients with iron deficiency anaemia undergoing upper endoscopy. All potential bleeding lesions were identified and gastric as well as duodenal biopsies were taken for histopathologic investigation.

RESULTS

A bleeding lesion is identified in 44% of cases. Duodenal biopsy gives an additional 5% diagnostic yield and revealed three patients with coeliac disease and two patients with giardiasis. One of the patients diagnosed with coeliac disease had a second bleeding lesion at the upper endoscopic examination. Appearance of the duodenal mucosa was normal in all patients including those with diagnostic duodenal biopsy.

CONCLUSIONS

Routine duodenal sampling during the upper endoscopic examination gives an additional 5% diagnostic benefit and this practice should be included in the diagnostic work-up of patients with iron deficiency anaemia. As one of the patients who was found to have coeliac disease had a second bleeding lesion that may otherwise explain iron deficiency anaemia, finding a source for bleeding at the upper endoscopy should not preclude duodenal biopsy. Moreover, performing duodenal biopsy is still necessary even though the endoscopic appearance of the mucosa is normal. Aside from coeliac disease, Giardia infestation could be identified as a contributory factor for iron deficiency anaemia, in endemic regions.

Authors+Show Affiliations

Department of Gastroenterology, Dokuz Eylul University School of Medicine, Izmir, Turkey. drcgnn@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17206075

Citation

Gonen, Can, et al. "Diagnostic Yield of Routine Duodenal Biopsies in Iron Deficiency Anaemia: a Study From Western Anatolia." European Journal of Gastroenterology & Hepatology, vol. 19, no. 1, 2007, pp. 37-41.
Gonen C, Yilmaz N, Yalcin M, et al. Diagnostic yield of routine duodenal biopsies in iron deficiency anaemia: a study from Western Anatolia. Eur J Gastroenterol Hepatol. 2007;19(1):37-41.
Gonen, C., Yilmaz, N., Yalcin, M., Simsek, I., & Gonen, O. (2007). Diagnostic yield of routine duodenal biopsies in iron deficiency anaemia: a study from Western Anatolia. European Journal of Gastroenterology & Hepatology, 19(1), 37-41.
Gonen C, et al. Diagnostic Yield of Routine Duodenal Biopsies in Iron Deficiency Anaemia: a Study From Western Anatolia. Eur J Gastroenterol Hepatol. 2007;19(1):37-41. PubMed PMID: 17206075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic yield of routine duodenal biopsies in iron deficiency anaemia: a study from Western Anatolia. AU - Gonen,Can, AU - Yilmaz,Nusret, AU - Yalcin,Muhittin, AU - Simsek,Ilkay, AU - Gonen,Omur, PY - 2007/1/9/pubmed PY - 2007/3/28/medline PY - 2007/1/9/entrez SP - 37 EP - 41 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 19 IS - 1 N2 - OBJECTIVE: The role of routine endoscopic duodenal biopsies obtained during the evaluation of iron deficiency anaemia is being increasingly emphasized, but insufficiently applied. Diagnostic yield of this practice, mainly identification of coeliac disease, differs in different populations and geographic regions. The aim of this study is to assess the usefulness of routine duodenal biopsies during upper endoscopy in patients presenting with iron deficiency anaemia in Western Anatolia. METHODS: Routine duodenal biopsies were evaluated over a 12-month period in 100 consecutive adult patients with iron deficiency anaemia undergoing upper endoscopy. All potential bleeding lesions were identified and gastric as well as duodenal biopsies were taken for histopathologic investigation. RESULTS: A bleeding lesion is identified in 44% of cases. Duodenal biopsy gives an additional 5% diagnostic yield and revealed three patients with coeliac disease and two patients with giardiasis. One of the patients diagnosed with coeliac disease had a second bleeding lesion at the upper endoscopic examination. Appearance of the duodenal mucosa was normal in all patients including those with diagnostic duodenal biopsy. CONCLUSIONS: Routine duodenal sampling during the upper endoscopic examination gives an additional 5% diagnostic benefit and this practice should be included in the diagnostic work-up of patients with iron deficiency anaemia. As one of the patients who was found to have coeliac disease had a second bleeding lesion that may otherwise explain iron deficiency anaemia, finding a source for bleeding at the upper endoscopy should not preclude duodenal biopsy. Moreover, performing duodenal biopsy is still necessary even though the endoscopic appearance of the mucosa is normal. Aside from coeliac disease, Giardia infestation could be identified as a contributory factor for iron deficiency anaemia, in endemic regions. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/17206075/Diagnostic_yield_of_routine_duodenal_biopsies_in_iron_deficiency_anaemia:_a_study_from_Western_Anatolia_ L2 - http://dx.doi.org/10.1097/01.meg.0000250583.07867.b7 DB - PRIME DP - Unbound Medicine ER -