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Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma.
Cancer Causes Control 2007; 18(4):351-9CC

Abstract

BACKGROUND

Family history of hematopoietic malignancies has been linked to the risk of non-Hodgkin lymphoma (NHL). The relationship between family history of specific hematopoietic and non-hematopoietic malignancies and the risk of NHL and by NHL subtypes are unclear.

METHODS

We analyzed data from a population-based case-control study in Connecticut women. A total of 601 histologically confirmed NHL incident cases and 717 randomly selected controls were included in the study. Unconditional logistic regression was used to estimate the association between family cancer history and risk of NHL overall and by NHL subtypes.

RESULTS

Compared to women who reported to have no family history of any malignancies in first-degree relatives, those who reported to have a family history of lymphoma (OR = 2.2, 95%CI: 1.1-4.5) or leukemia (OR = 2.5, 95%CI: 1.2-5.2) had an increased risk of NHL. The risk was higher among women who had a sibling with lymphoma or leukemia than those who had parents with lymphoma or leukemia. Several non-hematopoietic malignancies in first-degree relatives, including cancer of the lung (OR = 1.7, 95%CI: 1.1-2.6) in first-degree relatives, stomach (OR = 2.2, 95%CI: 0.8-5.9) and pancreas (OR = 2.6, 95%CI: 0.9-7.1) in parents, as well as liver (OR = 5.0, 95%CI: 1.0-24.6), breast (OR = 2.2, 95%CI: 1.3-3.9), cervix (OR = 7.5, 95%CI: 0.9-64.9), and ovary (OR = 3.5, 95%CI: 1.1-11.5) in siblings were also associated with an increased risk of NHL.

CONCLUSIONS

The risk associated with a family history of malignancies in first degree-relatives appears to vary by type of first-degree relatives.

Authors+Show Affiliations

Yale University School of Epidemiology and Public Health, 60 College Street, LEPH 440, New Haven, CT 06520, USA. yawei.zhang@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17206533

Citation

Zhang, Yawei, et al. "Family History of Hematopoietic and Non-hematopoietic Malignancies and Risk of non-Hodgkin Lymphoma." Cancer Causes & Control : CCC, vol. 18, no. 4, 2007, pp. 351-9.
Zhang Y, Wang R, Holford TR, et al. Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma. Cancer Causes Control. 2007;18(4):351-9.
Zhang, Y., Wang, R., Holford, T. R., Leaderer, B., Zahm, S. H., Boyle, P., ... Zheng, T. (2007). Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma. Cancer Causes & Control : CCC, 18(4), pp. 351-9.
Zhang Y, et al. Family History of Hematopoietic and Non-hematopoietic Malignancies and Risk of non-Hodgkin Lymphoma. Cancer Causes Control. 2007;18(4):351-9. PubMed PMID: 17206533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma. AU - Zhang,Yawei, AU - Wang,Rong, AU - Holford,Theodore R, AU - Leaderer,Brian, AU - Zahm,Shelia Hoar, AU - Boyle,Peter, AU - Zhu,Yong, AU - Qin,Qin, AU - Zheng,Tongzhang, Y1 - 2007/01/06/ PY - 2006/08/21/received PY - 2006/10/24/accepted PY - 2007/1/9/pubmed PY - 2007/6/8/medline PY - 2007/1/9/entrez SP - 351 EP - 9 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 18 IS - 4 N2 - BACKGROUND: Family history of hematopoietic malignancies has been linked to the risk of non-Hodgkin lymphoma (NHL). The relationship between family history of specific hematopoietic and non-hematopoietic malignancies and the risk of NHL and by NHL subtypes are unclear. METHODS: We analyzed data from a population-based case-control study in Connecticut women. A total of 601 histologically confirmed NHL incident cases and 717 randomly selected controls were included in the study. Unconditional logistic regression was used to estimate the association between family cancer history and risk of NHL overall and by NHL subtypes. RESULTS: Compared to women who reported to have no family history of any malignancies in first-degree relatives, those who reported to have a family history of lymphoma (OR = 2.2, 95%CI: 1.1-4.5) or leukemia (OR = 2.5, 95%CI: 1.2-5.2) had an increased risk of NHL. The risk was higher among women who had a sibling with lymphoma or leukemia than those who had parents with lymphoma or leukemia. Several non-hematopoietic malignancies in first-degree relatives, including cancer of the lung (OR = 1.7, 95%CI: 1.1-2.6) in first-degree relatives, stomach (OR = 2.2, 95%CI: 0.8-5.9) and pancreas (OR = 2.6, 95%CI: 0.9-7.1) in parents, as well as liver (OR = 5.0, 95%CI: 1.0-24.6), breast (OR = 2.2, 95%CI: 1.3-3.9), cervix (OR = 7.5, 95%CI: 0.9-64.9), and ovary (OR = 3.5, 95%CI: 1.1-11.5) in siblings were also associated with an increased risk of NHL. CONCLUSIONS: The risk associated with a family history of malignancies in first degree-relatives appears to vary by type of first-degree relatives. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17206533/Family_history_of_hematopoietic_and_non_hematopoietic_malignancies_and_risk_of_non_Hodgkin_lymphoma_ L2 - https://doi.org/10.1007/s10552-006-0088-5 DB - PRIME DP - Unbound Medicine ER -