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Effect of silk fibroin interpenetrating networks on swelling/deswelling kinetics and rheological properties of poly(N-isopropylacrylamide) hydrogels.

Abstract

Novel protein/synthetic polymer hybrid interpenetrating polymer networks (IPNs) of poly(N-isopropylacrylamide) (PNIPAAm) with Bombyx mori silk fibroin (SF) have been prepared by using methanol to postinduce SF crystallization. Those IPNs having the beta sheet crystalline structure of SF show improved storage and loss moduli. The IPN hydrogels show the same volume phase transition temperature and NaCl concentration as pure PNIPAAm hydrogels. The PNIPAAm/SF IPNs keep the swelling kinetics of PNIPAAm, while showing increased deswelling kinetics. The IPNs with SF beta sheet structure should decrease the formation of the skin layer observed in conventional PNIPAAm hydrogels. Therefore, the proposed IPN hydrogels composed of protein/polymer provide fast deswelling rates as well as improved mechanical properties over pure PNIPAAm hydrogels. The effect of SF beta sheet networks on the IPNs copolymerized with acrylic acid (AAc) (P(NIPAAm-co-AAc)/SF IPNs) is compared with that on the PNIPAAm/SF IPNs, and the parameters controlling the deswelling kinetics of the IPNs are investigated. Three parameters, (1) the skin layer formation, (2) the restriction of SF beta sheet networks, and (3) the aggregation force of NIPAAm chains, are cooperatively involved in the deswelling process of IPN hydrogels according to the SF content and the presence of the AAc moiety.

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  • Publisher Full Text
  • Authors

    ,

    Source

    Biomacromolecules 8:1 2007 Jan pg 258-64

    MeSH

    Acrylates
    Acrylic Resins
    Animals
    Bombyx
    Fibroins
    Hydrogels
    Kinetics
    Macromolecular Substances
    Molecular Conformation
    Oscillometry
    Polymers
    Protein Structure, Secondary
    Rheology
    Silk
    Sodium Chloride

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17206815

    Citation

    TY - JOUR T1 - Effect of silk fibroin interpenetrating networks on swelling/deswelling kinetics and rheological properties of poly(N-isopropylacrylamide) hydrogels. AU - Gil,Eun Seok, AU - Hudson,Samuel M, PY - 2007/1/9/pubmed PY - 2007/8/4/medline PY - 2007/1/9/entrez SP - 258 EP - 64 JF - Biomacromolecules JO - Biomacromolecules VL - 8 IS - 1 N2 - Novel protein/synthetic polymer hybrid interpenetrating polymer networks (IPNs) of poly(N-isopropylacrylamide) (PNIPAAm) with Bombyx mori silk fibroin (SF) have been prepared by using methanol to postinduce SF crystallization. Those IPNs having the beta sheet crystalline structure of SF show improved storage and loss moduli. The IPN hydrogels show the same volume phase transition temperature and NaCl concentration as pure PNIPAAm hydrogels. The PNIPAAm/SF IPNs keep the swelling kinetics of PNIPAAm, while showing increased deswelling kinetics. The IPNs with SF beta sheet structure should decrease the formation of the skin layer observed in conventional PNIPAAm hydrogels. Therefore, the proposed IPN hydrogels composed of protein/polymer provide fast deswelling rates as well as improved mechanical properties over pure PNIPAAm hydrogels. The effect of SF beta sheet networks on the IPNs copolymerized with acrylic acid (AAc) (P(NIPAAm-co-AAc)/SF IPNs) is compared with that on the PNIPAAm/SF IPNs, and the parameters controlling the deswelling kinetics of the IPNs are investigated. Three parameters, (1) the skin layer formation, (2) the restriction of SF beta sheet networks, and (3) the aggregation force of NIPAAm chains, are cooperatively involved in the deswelling process of IPN hydrogels according to the SF content and the presence of the AAc moiety. SN - 1525-7797 UR - https://www.unboundmedicine.com/medline/citation/17206815/Effect_of_silk_fibroin_interpenetrating_networks_on_swelling/deswelling_kinetics_and_rheological_properties_of_poly_N_isopropylacrylamide__hydrogels_ L2 - http://dx.doi.org/10.1021/bm060543m ER -