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Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium.
Curr Opin Microbiol. 2007 Feb; 10(1):24-9.CO

Abstract

Salmonella enterica invades the intestinal epithelium of the host using a type III secretion system encoded on Salmonella pathogenicity island 1 (SPI1). The bacteria integrate environmental signals from a variety of global regulatory systems to precisely induce transcription of SPI1. The regulatory circuit converges on expression of HilA, which directly regulates transcription of the SPI1 apparatus genes. Transcription of hilA is controlled by a complex feed-forward loop. Regulatory signals feed into the system through post-transcriptional and post-translational control of HilD, which in turn activates HilC and RtsA. These three regulators act in concert to control hilA transcription. The system acts as a switch, ensuring that SPI1 is fully on at the appropriate time.

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Authors+Show Affiliations

Ellermeier JR
Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA.
Slauch JM
No affiliation info available

MeSH

Adaptation, PhysiologicalBacterial ProteinsGene Expression Regulation, BacterialGenomic IslandsProtein TransportSalmonella typhimuriumTrans-ActivatorsTranscription FactorsTranscription, GeneticVirulence

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17208038

Citation

Ellermeier, Jeremy R., and James M. Slauch. "Adaptation to the Host Environment: Regulation of the SPI1 Type III Secretion System in Salmonella Enterica Serovar Typhimurium." Current Opinion in Microbiology, vol. 10, no. 1, 2007, pp. 24-9.
Ellermeier JR, Slauch JM. Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium. Curr Opin Microbiol. 2007;10(1):24-9.
Ellermeier, J. R., & Slauch, J. M. (2007). Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium. Current Opinion in Microbiology, 10(1), 24-9.
Ellermeier JR, Slauch JM. Adaptation to the Host Environment: Regulation of the SPI1 Type III Secretion System in Salmonella Enterica Serovar Typhimurium. Curr Opin Microbiol. 2007;10(1):24-9. PubMed PMID: 17208038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium. AU - Ellermeier,Jeremy R, AU - Slauch,James M, Y1 - 2007/01/05/ PY - 2006/10/23/received PY - 2006/12/18/accepted PY - 2007/1/9/pubmed PY - 2007/9/27/medline PY - 2007/1/9/entrez SP - 24 EP - 9 JF - Current opinion in microbiology JO - Curr Opin Microbiol VL - 10 IS - 1 N2 - Salmonella enterica invades the intestinal epithelium of the host using a type III secretion system encoded on Salmonella pathogenicity island 1 (SPI1). The bacteria integrate environmental signals from a variety of global regulatory systems to precisely induce transcription of SPI1. The regulatory circuit converges on expression of HilA, which directly regulates transcription of the SPI1 apparatus genes. Transcription of hilA is controlled by a complex feed-forward loop. Regulatory signals feed into the system through post-transcriptional and post-translational control of HilD, which in turn activates HilC and RtsA. These three regulators act in concert to control hilA transcription. The system acts as a switch, ensuring that SPI1 is fully on at the appropriate time. SN - 1369-5274 UR - https://www.unboundmedicine.com/medline/citation/17208038/Adaptation_to_the_host_environment:_regulation_of_the_SPI1_type_III_secretion_system_in_Salmonella_enterica_serovar_Typhimurium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1369-5274(06)00187-1 DB - PRIME DP - Unbound Medicine ER -