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Diurnal and seasonal variation of cholecystokinin peptides in humans.
Neuropeptides. 2007 Feb; 41(1):59-63.N

Abstract

Cholecystokinin (CCK) was determined in plasma obtained from 10 female (aged 23.4+/-SD 2.3 years) and nine male (aged 22.0+/-SD 1.4 years) healthy volunteers. Blood samples were drawn three times (8.00a.m., 12 noon and 8.00a.m.) on each of two sessions, one in the winter (November-December) and one in the summer (April-July). The participants had fasted (and were nicotine-free) since midnight preceding the sampling. A standardized breakfast was served after the first sampling. CCK was determined by radioimmunoassay. The area under the curve 0-24h (AUC)(CCK Winter) was lower than AUC(CCK Summer) (F(1:17)=4.73; P=0.0440) in the whole group of volunteers. On comparing the CCK concentrations within each session, there was an overall difference in winter (F(2:36)=14.81; P<0.0001) as well in summer (F(2:36)=18.39; P<0.0001). Post hoc comparisons yielded a difference between the 8.00a.m. and 12 noon concentrations on the first day in winter (t=-3.96; P=0.0009) as well as in summer (t=-4.64; P=0.0002). The difference between the summer and winter AUCs(CCK) correlated with the difference between AUCs for temperatures in summer and winter (r=0.58; P=0.0089). The correlation was accounted for by the females (r=0.73; P=0.0171). The results are in accord with a diurnal and a seasonal variation of CCK in human plasma.

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Authors+Show Affiliations

Lundberg K
Department of Neuroscience and Locomotion, Psychiatry Section, Faculty of Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.
Josefsson A
No affiliation info available
Nordin C
No affiliation info available

MeSH

AdultCholecystokininCircadian RhythmEstradiolFemaleHumansHydrocortisoneMalePeriodicityReference ValuesSeasonsTemperature

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17208296

Citation

Lundberg, Kristina, et al. "Diurnal and Seasonal Variation of Cholecystokinin Peptides in Humans." Neuropeptides, vol. 41, no. 1, 2007, pp. 59-63.
Lundberg K, Josefsson A, Nordin C. Diurnal and seasonal variation of cholecystokinin peptides in humans. Neuropeptides. 2007;41(1):59-63.
Lundberg, K., Josefsson, A., & Nordin, C. (2007). Diurnal and seasonal variation of cholecystokinin peptides in humans. Neuropeptides, 41(1), 59-63.
Lundberg K, Josefsson A, Nordin C. Diurnal and Seasonal Variation of Cholecystokinin Peptides in Humans. Neuropeptides. 2007;41(1):59-63. PubMed PMID: 17208296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diurnal and seasonal variation of cholecystokinin peptides in humans. AU - Lundberg,Kristina, AU - Josefsson,Ann, AU - Nordin,Conny, Y1 - 2007/01/08/ PY - 2006/06/19/received PY - 2006/09/01/revised PY - 2006/09/15/accepted PY - 2007/1/9/pubmed PY - 2007/8/7/medline PY - 2007/1/9/entrez SP - 59 EP - 63 JF - Neuropeptides JO - Neuropeptides VL - 41 IS - 1 N2 - Cholecystokinin (CCK) was determined in plasma obtained from 10 female (aged 23.4+/-SD 2.3 years) and nine male (aged 22.0+/-SD 1.4 years) healthy volunteers. Blood samples were drawn three times (8.00a.m., 12 noon and 8.00a.m.) on each of two sessions, one in the winter (November-December) and one in the summer (April-July). The participants had fasted (and were nicotine-free) since midnight preceding the sampling. A standardized breakfast was served after the first sampling. CCK was determined by radioimmunoassay. The area under the curve 0-24h (AUC)(CCK Winter) was lower than AUC(CCK Summer) (F(1:17)=4.73; P=0.0440) in the whole group of volunteers. On comparing the CCK concentrations within each session, there was an overall difference in winter (F(2:36)=14.81; P<0.0001) as well in summer (F(2:36)=18.39; P<0.0001). Post hoc comparisons yielded a difference between the 8.00a.m. and 12 noon concentrations on the first day in winter (t=-3.96; P=0.0009) as well as in summer (t=-4.64; P=0.0002). The difference between the summer and winter AUCs(CCK) correlated with the difference between AUCs for temperatures in summer and winter (r=0.58; P=0.0089). The correlation was accounted for by the females (r=0.73; P=0.0171). The results are in accord with a diurnal and a seasonal variation of CCK in human plasma. SN - 0143-4179 UR - https://www.unboundmedicine.com/medline/citation/17208296/Diurnal_and_seasonal_variation_of_cholecystokinin_peptides_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4179(06)00114-4 DB - PRIME DP - Unbound Medicine ER -