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Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer.
Cancer Lett 2007; 251(2):228-36CL

Abstract

Multiple studies have reported an association between disturbances of folate metabolism and increased risk of gastric cancer, including low intake of folate, low levels of folate in blood or genetic factors affecting folate metabolism. Among the genetic factors, in particular a common polymorphism in the gene encoding for 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) has been linked to gastric cancer. Other polymorphisms in folate-metabolising genes have been less frequently investigated. Therefore, we analyzed this polymorphism, the glutamate carboxypeptidase (GCP) II C1561T and the reduced folate carrier (RFC) G80A in a case-control study involving 106 patients with histologically confirmed and characterized gastric cancer with adjustment for other established risk factors for gastric cancer in comparison to 106 age- and sex-matched controls. Neither the MTHFR nor the GCP gene polymorphisms showed an association to cancer diagnosis, to tumor stage, grade of differentiation or Lauren type. However, non-cardia cancers were more likely to exhibit the 80GA and 80AA RFC genotypes, compared to cancers of the gastric cardia (adjusted OR 0.28; 95% CI=0.11-0.71). Thus, gene polymorphisms of the RFC gene might contribute to an increased risk of developing distal gastric cancer.

Authors+Show Affiliations

Department of Medicine II, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, D-81675 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17208363

Citation

Götze, Tobias, et al. "Gene Polymorphisms of Folate Metabolizing Enzymes and the Risk of Gastric Cancer." Cancer Letters, vol. 251, no. 2, 2007, pp. 228-36.
Götze T, Röcken C, Röhl FW, et al. Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. Cancer Lett. 2007;251(2):228-36.
Götze, T., Röcken, C., Röhl, F. W., Wex, T., Hoffmann, J., Westphal, S., ... Dierkes, J. (2007). Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. Cancer Letters, 251(2), pp. 228-36.
Götze T, et al. Gene Polymorphisms of Folate Metabolizing Enzymes and the Risk of Gastric Cancer. Cancer Lett. 2007 Jun 28;251(2):228-36. PubMed PMID: 17208363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. AU - Götze,Tobias, AU - Röcken,Christoph, AU - Röhl,Friedrich W, AU - Wex,Thomas, AU - Hoffmann,Juliane, AU - Westphal,Sabine, AU - Malfertheiner,Peter, AU - Ebert,Matthias P A, AU - Dierkes,Jutta, Y1 - 2007/01/08/ PY - 2006/11/07/received PY - 2006/11/21/revised PY - 2006/11/22/accepted PY - 2007/1/9/pubmed PY - 2007/7/18/medline PY - 2007/1/9/entrez SP - 228 EP - 36 JF - Cancer letters JO - Cancer Lett. VL - 251 IS - 2 N2 - Multiple studies have reported an association between disturbances of folate metabolism and increased risk of gastric cancer, including low intake of folate, low levels of folate in blood or genetic factors affecting folate metabolism. Among the genetic factors, in particular a common polymorphism in the gene encoding for 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) has been linked to gastric cancer. Other polymorphisms in folate-metabolising genes have been less frequently investigated. Therefore, we analyzed this polymorphism, the glutamate carboxypeptidase (GCP) II C1561T and the reduced folate carrier (RFC) G80A in a case-control study involving 106 patients with histologically confirmed and characterized gastric cancer with adjustment for other established risk factors for gastric cancer in comparison to 106 age- and sex-matched controls. Neither the MTHFR nor the GCP gene polymorphisms showed an association to cancer diagnosis, to tumor stage, grade of differentiation or Lauren type. However, non-cardia cancers were more likely to exhibit the 80GA and 80AA RFC genotypes, compared to cancers of the gastric cardia (adjusted OR 0.28; 95% CI=0.11-0.71). Thus, gene polymorphisms of the RFC gene might contribute to an increased risk of developing distal gastric cancer. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/17208363/Gene_polymorphisms_of_folate_metabolizing_enzymes_and_the_risk_of_gastric_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(06)00657-4 DB - PRIME DP - Unbound Medicine ER -