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Respiratory illnesses in early life and asthma and atopy in childhood.
J Allergy Clin Immunol. 2007 Jan; 119(1):150-6.JA

Abstract

BACKGROUND

The relation between respiratory illnesses in early life and the development of asthma and atopy in childhood is incompletely understood.

OBJECTIVE

We sought to examine the relationship between respiratory illnesses in early life and atopic diseases at school age.

METHODS

We performed a prospective birth cohort study of the relationship between respiratory illnesses in the first year of life and asthma, atopy (sensitization to >or=1 allergen), and allergic rhinitis at school age in 440 children with a parental history of atopy. Logistic regression was used to examine the relationship between respiratory illnesses and asthma, atopy, and allergic rhinitis. The relationship between respiratory illnesses in early life and repeated measures of wheezing between the ages of 1 and 7 years was investigated by using a proportional hazards models.

RESULTS

Physician-diagnosed croup (adjusted odds ratio [OR], 0.30; 95% CI, 0.12-0.72) and having 2 or more physician-diagnosed ear infections (adjusted OR, 0.58; 95% CI, 0.35-0.98) in the first year of life were inversely associated with atopy at school age. Physician-diagnosed bronchiolitis before age 1 year was significantly associated with asthma at age 7 years (adjusted OR, 2.77; 95% CI, 1.23-6.22). Recurrent nasal catarrh (>or=3 episodes of a runny nose) in the first year of life was associated with allergic rhinitis at age 7 years (adjusted OR, 2.99; 95% CI, 1.03-8.67).

CONCLUSION

The relationship between early-life respiratory illnesses and asthma and atopy is complex and likely dependent on the type of infection and immune response it initiates.

CLINICAL IMPLICATIONS

Certain respiratory illnesses in early life modify the risk of atopy and asthma at school age.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17208596

Citation

Ramsey, Clare D., et al. "Respiratory Illnesses in Early Life and Asthma and Atopy in Childhood." The Journal of Allergy and Clinical Immunology, vol. 119, no. 1, 2007, pp. 150-6.
Ramsey CD, Gold DR, Litonjua AA, et al. Respiratory illnesses in early life and asthma and atopy in childhood. J Allergy Clin Immunol. 2007;119(1):150-6.
Ramsey, C. D., Gold, D. R., Litonjua, A. A., Sredl, D. L., Ryan, L., & Celedón, J. C. (2007). Respiratory illnesses in early life and asthma and atopy in childhood. The Journal of Allergy and Clinical Immunology, 119(1), 150-6.
Ramsey CD, et al. Respiratory Illnesses in Early Life and Asthma and Atopy in Childhood. J Allergy Clin Immunol. 2007;119(1):150-6. PubMed PMID: 17208596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory illnesses in early life and asthma and atopy in childhood. AU - Ramsey,Clare D, AU - Gold,Diane R, AU - Litonjua,Augusto A, AU - Sredl,Diane L, AU - Ryan,Louise, AU - Celedón,Juan C, Y1 - 2006/10/23/ PY - 2006/05/04/received PY - 2006/09/11/revised PY - 2006/09/13/accepted PY - 2007/1/9/pubmed PY - 2007/3/14/medline PY - 2007/1/9/entrez SP - 150 EP - 6 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 119 IS - 1 N2 - BACKGROUND: The relation between respiratory illnesses in early life and the development of asthma and atopy in childhood is incompletely understood. OBJECTIVE: We sought to examine the relationship between respiratory illnesses in early life and atopic diseases at school age. METHODS: We performed a prospective birth cohort study of the relationship between respiratory illnesses in the first year of life and asthma, atopy (sensitization to >or=1 allergen), and allergic rhinitis at school age in 440 children with a parental history of atopy. Logistic regression was used to examine the relationship between respiratory illnesses and asthma, atopy, and allergic rhinitis. The relationship between respiratory illnesses in early life and repeated measures of wheezing between the ages of 1 and 7 years was investigated by using a proportional hazards models. RESULTS: Physician-diagnosed croup (adjusted odds ratio [OR], 0.30; 95% CI, 0.12-0.72) and having 2 or more physician-diagnosed ear infections (adjusted OR, 0.58; 95% CI, 0.35-0.98) in the first year of life were inversely associated with atopy at school age. Physician-diagnosed bronchiolitis before age 1 year was significantly associated with asthma at age 7 years (adjusted OR, 2.77; 95% CI, 1.23-6.22). Recurrent nasal catarrh (>or=3 episodes of a runny nose) in the first year of life was associated with allergic rhinitis at age 7 years (adjusted OR, 2.99; 95% CI, 1.03-8.67). CONCLUSION: The relationship between early-life respiratory illnesses and asthma and atopy is complex and likely dependent on the type of infection and immune response it initiates. CLINICAL IMPLICATIONS: Certain respiratory illnesses in early life modify the risk of atopy and asthma at school age. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/17208596/Respiratory_illnesses_in_early_life_and_asthma_and_atopy_in_childhood_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(06)01912-9 DB - PRIME DP - Unbound Medicine ER -