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Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome.
Hum Reprod. 2007 Apr; 22(4):1100-6.HR

Abstract

BACKGROUND

The aim of this study was to investigate serum and adipocyte mRNA expression of resistin in lean and obese women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE).

METHODS

Adipose tissue obtained from 12 women with PCOS (six obese and six lean, body mass index > 27 kg m(-1) as threshold point) before and after LOE was analysed. Gene expression of resistin was measured by semi-quantitative RT-PCR. Ten lean, age-matched healthy women served as controls.

RESULTS

Both lean and obese women with PCOS had significantly higher fasting and 2 h insulin and homeostasis model insulin resistance index (HOMA(IR)) values and lower fasting glucose-to-insulin ratios (G(0)/I(0)) than did the controls. The serum levels of glucose and insulin and HOMA(IR) were significantly decreased, and the G(0)/I(0) ratio was significantly increased 3 months after LOE. No difference was found in serum resistin levels between controls and either obese or lean women with PCOS before LOE, nor between PCOS patients before and after LOE. However, resistin mRNA expression levels in both lean and obese women with PCOS before LOE were significantly higher than that in controls and were decreased significantly after LOE back to control levels.

CONCLUSION

Local resistin activity may be actively involved in the pathogenesis of PCOS. LOE reduces insulin resistance and down-regulates resistin mRNA expression in lean and obese women with PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17208941

Citation

Seow, Kok-Min, et al. "Adipocyte Resistin mRNA Levels Are Down-regulated By Laparoscopic Ovarian Electrocautery in Both Obese and Lean Women With Polycystic Ovary Syndrome." Human Reproduction (Oxford, England), vol. 22, no. 4, 2007, pp. 1100-6.
Seow KM, Juan CC, Ho LT, et al. Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome. Hum Reprod. 2007;22(4):1100-6.
Seow, K. M., Juan, C. C., Ho, L. T., Hsu, Y. P., Lin, Y. H., Huang, L. W., & Hwang, J. L. (2007). Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome. Human Reproduction (Oxford, England), 22(4), 1100-6.
Seow KM, et al. Adipocyte Resistin mRNA Levels Are Down-regulated By Laparoscopic Ovarian Electrocautery in Both Obese and Lean Women With Polycystic Ovary Syndrome. Hum Reprod. 2007;22(4):1100-6. PubMed PMID: 17208941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome. AU - Seow,Kok-Min, AU - Juan,Chi-Chang, AU - Ho,Low-Tone, AU - Hsu,Yung-Pei, AU - Lin,Yu-Hung, AU - Huang,Lee-Wen, AU - Hwang,Jiann-Loung, Y1 - 2007/01/05/ PY - 2007/1/9/pubmed PY - 2007/7/4/medline PY - 2007/1/9/entrez SP - 1100 EP - 6 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 22 IS - 4 N2 - BACKGROUND: The aim of this study was to investigate serum and adipocyte mRNA expression of resistin in lean and obese women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). METHODS: Adipose tissue obtained from 12 women with PCOS (six obese and six lean, body mass index > 27 kg m(-1) as threshold point) before and after LOE was analysed. Gene expression of resistin was measured by semi-quantitative RT-PCR. Ten lean, age-matched healthy women served as controls. RESULTS: Both lean and obese women with PCOS had significantly higher fasting and 2 h insulin and homeostasis model insulin resistance index (HOMA(IR)) values and lower fasting glucose-to-insulin ratios (G(0)/I(0)) than did the controls. The serum levels of glucose and insulin and HOMA(IR) were significantly decreased, and the G(0)/I(0) ratio was significantly increased 3 months after LOE. No difference was found in serum resistin levels between controls and either obese or lean women with PCOS before LOE, nor between PCOS patients before and after LOE. However, resistin mRNA expression levels in both lean and obese women with PCOS before LOE were significantly higher than that in controls and were decreased significantly after LOE back to control levels. CONCLUSION: Local resistin activity may be actively involved in the pathogenesis of PCOS. LOE reduces insulin resistance and down-regulates resistin mRNA expression in lean and obese women with PCOS. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/17208941/Adipocyte_resistin_mRNA_levels_are_down_regulated_by_laparoscopic_ovarian_electrocautery_in_both_obese_and_lean_women_with_polycystic_ovary_syndrome_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/del489 DB - PRIME DP - Unbound Medicine ER -