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Haemostatic variables and their relationship to body mass index and blood pressure in adult Nigerians with the sickle cell trait.
Clin Hemorheol Microcirc. 2007; 36(1):89-94.CH

Abstract

Several studies had assessed the rheological and haemostatic parameters in both sickle cell anaemia(HbSS) and haemoglobin AA(HbAA) subjects. The effect of the heterogeneous state on these parameters has not been fully determined. Our aim was to assess the haemorheological and haemostatic parameters and there relationship to body mass index in individuals with the sickle cell trait. Fifty eight males (41 HbAA and 17 HbAS) who were neither smokers nor drinkers were studied. Body mass index was calculated as weight in Kg divided by height in m(2), blood samples were analysed for haematocrit, erythrocyte sedimentation rate, platelets, fibrinogen and factor VII by standard methods. There were no significant differences in the levels of haemostatic and cardiovascular risk factors between the HbAA and HbAS individuals. Fibrinogen correlated positively with BMI (r=0.6014, p=0.0107), systolic blood pressure (r=0.4820, p=0.0570), diastolic blood pressure (r=0.4699, p=0.0570) in HbAS individuals. The body mass index also correlated positively with diastolic blood pressure (r=0.5182, p<0.05), and systolic blood pressure (r=0.6189, p<0.01). Positive associations were also found between fibrinogen and body mass index (r=0.5012, p=0.0008), and fibrinogen and haematocrit (r=0.3696, r=0.0174) respectively in HbAA subjects. We conclude that the lack of significant difference in both haemorheological and cardiovascular risk factors in HbAS and HbAA subjects has further supported the observation that HbAS is a benign condition under physiological settings. Also the positive associations of fibrinogen with other cardiovascular risk factors have further underscored the central role of fibrinogen as an independent risk factors in the development of cardiovascular diseases.

Authors+Show Affiliations

Department of Haematology, School of Medicine, College of Medical Sciences, University of Benin, Benin-city, Edo-state, Nigeria, West-Africa. ladeawodu@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17211065

Citation

Awodu, O A., and A A. Famodu. "Haemostatic Variables and Their Relationship to Body Mass Index and Blood Pressure in Adult Nigerians With the Sickle Cell Trait." Clinical Hemorheology and Microcirculation, vol. 36, no. 1, 2007, pp. 89-94.
Awodu OA, Famodu AA. Haemostatic variables and their relationship to body mass index and blood pressure in adult Nigerians with the sickle cell trait. Clin Hemorheol Microcirc. 2007;36(1):89-94.
Awodu, O. A., & Famodu, A. A. (2007). Haemostatic variables and their relationship to body mass index and blood pressure in adult Nigerians with the sickle cell trait. Clinical Hemorheology and Microcirculation, 36(1), 89-94.
Awodu OA, Famodu AA. Haemostatic Variables and Their Relationship to Body Mass Index and Blood Pressure in Adult Nigerians With the Sickle Cell Trait. Clin Hemorheol Microcirc. 2007;36(1):89-94. PubMed PMID: 17211065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemostatic variables and their relationship to body mass index and blood pressure in adult Nigerians with the sickle cell trait. AU - Awodu,O A, AU - Famodu,A A, PY - 2007/1/11/pubmed PY - 2007/4/25/medline PY - 2007/1/11/entrez SP - 89 EP - 94 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 36 IS - 1 N2 - Several studies had assessed the rheological and haemostatic parameters in both sickle cell anaemia(HbSS) and haemoglobin AA(HbAA) subjects. The effect of the heterogeneous state on these parameters has not been fully determined. Our aim was to assess the haemorheological and haemostatic parameters and there relationship to body mass index in individuals with the sickle cell trait. Fifty eight males (41 HbAA and 17 HbAS) who were neither smokers nor drinkers were studied. Body mass index was calculated as weight in Kg divided by height in m(2), blood samples were analysed for haematocrit, erythrocyte sedimentation rate, platelets, fibrinogen and factor VII by standard methods. There were no significant differences in the levels of haemostatic and cardiovascular risk factors between the HbAA and HbAS individuals. Fibrinogen correlated positively with BMI (r=0.6014, p=0.0107), systolic blood pressure (r=0.4820, p=0.0570), diastolic blood pressure (r=0.4699, p=0.0570) in HbAS individuals. The body mass index also correlated positively with diastolic blood pressure (r=0.5182, p<0.05), and systolic blood pressure (r=0.6189, p<0.01). Positive associations were also found between fibrinogen and body mass index (r=0.5012, p=0.0008), and fibrinogen and haematocrit (r=0.3696, r=0.0174) respectively in HbAA subjects. We conclude that the lack of significant difference in both haemorheological and cardiovascular risk factors in HbAS and HbAA subjects has further supported the observation that HbAS is a benign condition under physiological settings. Also the positive associations of fibrinogen with other cardiovascular risk factors have further underscored the central role of fibrinogen as an independent risk factors in the development of cardiovascular diseases. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/17211065/Haemostatic_variables_and_their_relationship_to_body_mass_index_and_blood_pressure_in_adult_Nigerians_with_the_sickle_cell_trait_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1386-0291&amp;volume=36&amp;issue=1&amp;spage=89 DB - PRIME DP - Unbound Medicine ER -