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The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific.
Psychopharmacology (Berl). 2007 Apr; 191(2):223-31.P

Abstract

RATIONALE

Disruption of CB(1) receptor signaling through the use of CB(1) (-/-) mice or the CB(1) receptor antagonist rimonabant (SR141716) has been demonstrated to impair extinction of learned responses in conditioned fear and Morris water maze tasks. In contrast, CB(1) (-/-) mice exhibited normal extinction rates in an appetitively motivated operant conditioning task.

OBJECTIVES

The purpose of this study was to test whether rimonabant would differentially disrupt extinction learning between fear-motivated and food-motivated tasks.

MATERIALS AND METHODS

Separate groups of C57BL/6J mice were trained in two aversively motivated tasks, conditioned freezing and passive avoidance, and an appetitively motivated operant conditioning task at a fixed ratio (FR-5) schedule of food reinforcement. After acquisition, the respective reinforcers in each task were withheld, and an intraperitoneal injection of vehicle or rimonabant was given 30 min before each extinction session.

RESULTS

Rimonabant (3 mg/kg) treatment significantly disrupted extinction in both the conditioned freezing and passive avoidance tasks but failed to affect extinction rates in the operant conditioning task, whether using daily or weekly extinction sessions. Interestingly, rimonabant (3 mg/kg) prevented the significant increases in lever pressing (i.e., extinction burst) that occurred during the first extinction session of the operant conditioning task.

CONCLUSIONS

These results support the hypothesis that the CB(1) receptor plays a vital role in the extinction of aversive memories but is not essential for extinction of learned responses in appetitively motivated tasks.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17211653

Citation

Niyuhire, Floride, et al. "The Disruptive Effects of the CB1 Receptor Antagonist Rimonabant On Extinction Learning in Mice Are Task-specific." Psychopharmacology, vol. 191, no. 2, 2007, pp. 223-31.
Niyuhire F, Varvel SA, Thorpe AJ, et al. The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific. Psychopharmacology (Berl). 2007;191(2):223-31.
Niyuhire, F., Varvel, S. A., Thorpe, A. J., Stokes, R. J., Wiley, J. L., & Lichtman, A. H. (2007). The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific. Psychopharmacology, 191(2), 223-31.
Niyuhire F, et al. The Disruptive Effects of the CB1 Receptor Antagonist Rimonabant On Extinction Learning in Mice Are Task-specific. Psychopharmacology (Berl). 2007;191(2):223-31. PubMed PMID: 17211653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific. AU - Niyuhire,Floride, AU - Varvel,Stephen A, AU - Thorpe,Andrew J, AU - Stokes,Rene J, AU - Wiley,Jenny L, AU - Lichtman,Aron H, Y1 - 2007/01/09/ PY - 2006/05/12/received PY - 2006/11/11/accepted PY - 2007/1/11/pubmed PY - 2007/6/26/medline PY - 2007/1/11/entrez SP - 223 EP - 31 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 191 IS - 2 N2 - RATIONALE: Disruption of CB(1) receptor signaling through the use of CB(1) (-/-) mice or the CB(1) receptor antagonist rimonabant (SR141716) has been demonstrated to impair extinction of learned responses in conditioned fear and Morris water maze tasks. In contrast, CB(1) (-/-) mice exhibited normal extinction rates in an appetitively motivated operant conditioning task. OBJECTIVES: The purpose of this study was to test whether rimonabant would differentially disrupt extinction learning between fear-motivated and food-motivated tasks. MATERIALS AND METHODS: Separate groups of C57BL/6J mice were trained in two aversively motivated tasks, conditioned freezing and passive avoidance, and an appetitively motivated operant conditioning task at a fixed ratio (FR-5) schedule of food reinforcement. After acquisition, the respective reinforcers in each task were withheld, and an intraperitoneal injection of vehicle or rimonabant was given 30 min before each extinction session. RESULTS: Rimonabant (3 mg/kg) treatment significantly disrupted extinction in both the conditioned freezing and passive avoidance tasks but failed to affect extinction rates in the operant conditioning task, whether using daily or weekly extinction sessions. Interestingly, rimonabant (3 mg/kg) prevented the significant increases in lever pressing (i.e., extinction burst) that occurred during the first extinction session of the operant conditioning task. CONCLUSIONS: These results support the hypothesis that the CB(1) receptor plays a vital role in the extinction of aversive memories but is not essential for extinction of learned responses in appetitively motivated tasks. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/17211653/The_disruptive_effects_of_the_CB1_receptor_antagonist_rimonabant_on_extinction_learning_in_mice_are_task_specific_ L2 - https://dx.doi.org/10.1007/s00213-006-0650-6 DB - PRIME DP - Unbound Medicine ER -