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Pursiainen V, Korpelainen TJ, Haapaniemi HT, et al. Selegiline and blood pressure in patients with Parkinson's disease. Acta Neurol Scand. 2007;115(2):104-8.
Pursiainen, V., Korpelainen, T. J., Haapaniemi, H. T., Sotaniemi, A. K., & Myllylä, V. V. (2007). Selegiline and blood pressure in patients with Parkinson's disease. Acta Neurologica Scandinavica, 115(2), 104-8.
Pursiainen V, et al. Selegiline and Blood Pressure in Patients With Parkinson's Disease. Acta Neurol Scand. 2007;115(2):104-8. PubMed PMID: 17212613.
TY - JOUR
T1 - Selegiline and blood pressure in patients with Parkinson's disease.
AU - Pursiainen,V,
AU - Korpelainen,T J,
AU - Haapaniemi,H T,
AU - Sotaniemi,A K,
AU - Myllylä,V V,
PY - 2007/1/11/pubmed
PY - 2007/3/21/medline
PY - 2007/1/11/entrez
SP - 104
EP - 8
JF - Acta neurologica Scandinavica
JO - Acta Neurol Scand
VL - 115
IS - 2
N2 - OBJECTIVES: Parkinson's disease (PD) frequently affects both the extrapyramidal system and the autonomic nervous system (ANS), the latter also being sometimes disturbed by PD medications. Specifically selegiline is known to disturb cardiovascular ANS functions and may cause or enhance orthostatic hypotension. METHODS: In order to study the effect of the withdrawal of selegiline on the regulation of blood pressure (BP) in advanced PD, an orthostatic test was performed in 14 PD patients with wearing-off before the morning levodopa dose and thereafter repetitively at 1-h intervals for up to 4 h. A Unified Parkinson's Disease Rating Scale motor score evaluation was also carried out hourly. The tests were repeated after a 4-week selegiline washout period. RESULTS: Selegiline withdrawal decreased systolic BP significantly during the on-stage in a supine position as well as during the orthostatic test. The initial drop of BP in the orthostatic test was significantly smaller after selegiline withdrawal. The heart rate remained unaffected.
SN - 0001-6314
UR - https://www.unboundmedicine.com/medline/citation/17212613/Selegiline_and_blood_pressure_in_patients_with_Parkinson's_disease_
L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=2007&volume=115&issue=2&spage=104
DB - PRIME
DP - Unbound Medicine