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Selegiline and blood pressure in patients with Parkinson's disease.
Acta Neurol Scand. 2007 Feb; 115(2):104-8.AN

Abstract

OBJECTIVES

Parkinson's disease (PD) frequently affects both the extrapyramidal system and the autonomic nervous system (ANS), the latter also being sometimes disturbed by PD medications. Specifically selegiline is known to disturb cardiovascular ANS functions and may cause or enhance orthostatic hypotension.

METHODS

In order to study the effect of the withdrawal of selegiline on the regulation of blood pressure (BP) in advanced PD, an orthostatic test was performed in 14 PD patients with wearing-off before the morning levodopa dose and thereafter repetitively at 1-h intervals for up to 4 h. A Unified Parkinson's Disease Rating Scale motor score evaluation was also carried out hourly. The tests were repeated after a 4-week selegiline washout period.

RESULTS

Selegiline withdrawal decreased systolic BP significantly during the on-stage in a supine position as well as during the orthostatic test. The initial drop of BP in the orthostatic test was significantly smaller after selegiline withdrawal. The heart rate remained unaffected.

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Authors+Show Affiliations

Pursiainen V
Department of Neurology, Oulu University Hospital, Oulu, Finland. ville.pursiainen@sci.fi
Korpelainen TJ
No affiliation info available
Haapaniemi HT
No affiliation info available
Sotaniemi AK
No affiliation info available
Myllylä VV
No affiliation info available

MeSH

AgedAntiparkinson AgentsAutonomic Nervous SystemBlood PressureFemaleHeart RateHumansMaleMiddle AgedParkinson DiseasePostureSelegiline

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17212613

Citation

Pursiainen, V, et al. "Selegiline and Blood Pressure in Patients With Parkinson's Disease." Acta Neurologica Scandinavica, vol. 115, no. 2, 2007, pp. 104-8.
Pursiainen V, Korpelainen TJ, Haapaniemi HT, et al. Selegiline and blood pressure in patients with Parkinson's disease. Acta Neurol Scand. 2007;115(2):104-8.
Pursiainen, V., Korpelainen, T. J., Haapaniemi, H. T., Sotaniemi, A. K., & Myllylä, V. V. (2007). Selegiline and blood pressure in patients with Parkinson's disease. Acta Neurologica Scandinavica, 115(2), 104-8.
Pursiainen V, et al. Selegiline and Blood Pressure in Patients With Parkinson's Disease. Acta Neurol Scand. 2007;115(2):104-8. PubMed PMID: 17212613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selegiline and blood pressure in patients with Parkinson's disease. AU - Pursiainen,V, AU - Korpelainen,T J, AU - Haapaniemi,H T, AU - Sotaniemi,A K, AU - Myllylä,V V, PY - 2007/1/11/pubmed PY - 2007/3/21/medline PY - 2007/1/11/entrez SP - 104 EP - 8 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 115 IS - 2 N2 - OBJECTIVES: Parkinson's disease (PD) frequently affects both the extrapyramidal system and the autonomic nervous system (ANS), the latter also being sometimes disturbed by PD medications. Specifically selegiline is known to disturb cardiovascular ANS functions and may cause or enhance orthostatic hypotension. METHODS: In order to study the effect of the withdrawal of selegiline on the regulation of blood pressure (BP) in advanced PD, an orthostatic test was performed in 14 PD patients with wearing-off before the morning levodopa dose and thereafter repetitively at 1-h intervals for up to 4 h. A Unified Parkinson's Disease Rating Scale motor score evaluation was also carried out hourly. The tests were repeated after a 4-week selegiline washout period. RESULTS: Selegiline withdrawal decreased systolic BP significantly during the on-stage in a supine position as well as during the orthostatic test. The initial drop of BP in the orthostatic test was significantly smaller after selegiline withdrawal. The heart rate remained unaffected. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/17212613/Selegiline_and_blood_pressure_in_patients_with_Parkinson's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=2007&volume=115&issue=2&spage=104 DB - PRIME DP - Unbound Medicine ER -