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Menopause, but not age, is an independent risk factor for fasting plasma glucose levels in nondiabetic women.
Menopause. 2007 May-Jun; 14(3 Pt 1):404-7.M

Abstract

OBJECTIVE

Glucose metabolism is influenced by various genetic and environmental factors. In women the prevalence of abnormal glucose metabolism is known to increase around and after age 50. The aim of this study was to determine whether menopause augments fasting plasma glucose (FPG) levels in women.

DESIGN

Of 672 Japanese women who underwent health examinations, we studied 505 nondiabetic participants who had no history of hysterectomy and had never used estrogens or progestins. All participants were administered an oral glucose tolerance test, and their blood measurements and information about their menopause status were obtained.

RESULTS

Of these 505 women, 208 were premenopausal and 297 were postmenopausal. Age, body mass index, triglycerides level, total cholesterol level, low-density lipoprotein cholesterol level, blood pressure, and homeostasis model assessment insulin sensitivity index rose across quintiles of FPG levels, whereas high-density lipoprotein cholesterol level and homeostasis model assessment pancreatic beta-cell function index did not. The number of premenopausal women declined and the number of postmenopausal women increased across quintiles of FPG levels. Univariate regression analysis demonstrated that age, body mass index, triglycerides level, low-density lipoprotein cholesterol level, and menopause status were associated with FPG level, whereas high-density lipoprotein cholesterol level was not. Stepwise multivariate regression analysis showed that the independent risk factors for elevated FPG levels were body mass index, menopause, and triglycerides level, whereas age and low-density lipoprotein cholesterol level did not contribute to FPG levels.

CONCLUSIONS

Menopause, but not age, is directly involved in augmented FPG levels in nondiabetic women.

Authors+Show Affiliations

Department of Medicine, Osaka University Graduate School of Medicine, Suita, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17213751

Citation

Otsuki, Michio, et al. "Menopause, but Not Age, Is an Independent Risk Factor for Fasting Plasma Glucose Levels in Nondiabetic Women." Menopause (New York, N.Y.), vol. 14, no. 3 Pt 1, 2007, pp. 404-7.
Otsuki M, Kasayama S, Morita S, et al. Menopause, but not age, is an independent risk factor for fasting plasma glucose levels in nondiabetic women. Menopause. 2007;14(3 Pt 1):404-7.
Otsuki, M., Kasayama, S., Morita, S., Asanuma, N., Saito, H., Mukai, M., & Koga, M. (2007). Menopause, but not age, is an independent risk factor for fasting plasma glucose levels in nondiabetic women. Menopause (New York, N.Y.), 14(3 Pt 1), 404-7.
Otsuki M, et al. Menopause, but Not Age, Is an Independent Risk Factor for Fasting Plasma Glucose Levels in Nondiabetic Women. Menopause. 2007 May-Jun;14(3 Pt 1):404-7. PubMed PMID: 17213751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Menopause, but not age, is an independent risk factor for fasting plasma glucose levels in nondiabetic women. AU - Otsuki,Michio, AU - Kasayama,Soji, AU - Morita,Shinya, AU - Asanuma,Nobuyuki, AU - Saito,Hiroshi, AU - Mukai,Mikio, AU - Koga,Masafumi, PY - 2007/1/11/pubmed PY - 2007/7/13/medline PY - 2007/1/11/entrez SP - 404 EP - 7 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 3 Pt 1 N2 - OBJECTIVE: Glucose metabolism is influenced by various genetic and environmental factors. In women the prevalence of abnormal glucose metabolism is known to increase around and after age 50. The aim of this study was to determine whether menopause augments fasting plasma glucose (FPG) levels in women. DESIGN: Of 672 Japanese women who underwent health examinations, we studied 505 nondiabetic participants who had no history of hysterectomy and had never used estrogens or progestins. All participants were administered an oral glucose tolerance test, and their blood measurements and information about their menopause status were obtained. RESULTS: Of these 505 women, 208 were premenopausal and 297 were postmenopausal. Age, body mass index, triglycerides level, total cholesterol level, low-density lipoprotein cholesterol level, blood pressure, and homeostasis model assessment insulin sensitivity index rose across quintiles of FPG levels, whereas high-density lipoprotein cholesterol level and homeostasis model assessment pancreatic beta-cell function index did not. The number of premenopausal women declined and the number of postmenopausal women increased across quintiles of FPG levels. Univariate regression analysis demonstrated that age, body mass index, triglycerides level, low-density lipoprotein cholesterol level, and menopause status were associated with FPG level, whereas high-density lipoprotein cholesterol level was not. Stepwise multivariate regression analysis showed that the independent risk factors for elevated FPG levels were body mass index, menopause, and triglycerides level, whereas age and low-density lipoprotein cholesterol level did not contribute to FPG levels. CONCLUSIONS: Menopause, but not age, is directly involved in augmented FPG levels in nondiabetic women. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17213751/Menopause_but_not_age_is_an_independent_risk_factor_for_fasting_plasma_glucose_levels_in_nondiabetic_women_ L2 - http://dx.doi.org/10.1097/01.gme.0000247014.56254.12 DB - PRIME DP - Unbound Medicine ER -