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Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women.
Menopause 2007 May-Jun; 14(3 Pt 1):481-8M

Abstract

OBJECTIVE

The aim of this study was to assess the independent and additive effects of soy protein isolate (SPI) and moderate-intensity exercise (EX) on bone turnover and bone mineral density (BMD).

DESIGN

This study used a placebo-controlled, double-blind (soy), randomized 2 (SPI vs milk protein isolate [MPI]) x 2 (EX vs no EX) design. Sixty-one postmenopausal women were randomized, and 43 (62 +/- 5 y) completed the 9-month intervention (SPI, n = 10; MPI, n = 12; SPI + EX, n = 11; MPI + EX, n = 10). Serum C-terminal cross-linked telopeptides of type I collagen and serum bone-specific alkaline phosphatase were measured as markers of bone resorption and formation, respectively. BMD was measured by dual-energy x-ray absorptiometry.

RESULTS

At 9 months, SPI reduced serum C-terminal cross-linked telopeptides (-13.3% +/- 15.3% vs -1.5% +/- 21.0%; P = 0.02) and serum bone-specific alkaline phosphatase (-4.7% +/- 14.7% vs 6.5% +/- 17.7%; P = 0.02) compared to milk protein isolate. EX attenuated the reduction in serum C-terminal cross-linked telopeptides (-1.9% +/- 21.6% vs -12.4% +/- 15.3%; P = 0.04); however, no EX effects were apparent in serum bone-specific alkaline phosphatase at 9 months (2.8% +/- 16.1% vs -1.0% +/- 18.3%; P = 0.28). Neither SPI nor EX affected BMD at any site; however, change in BMD was related to change in fat mass (r = 0.40, P < 0.05).

CONCLUSIONS

In postmenopausal women (1) SPI reduces bone turnover with no impact on BMD over 9 months; (2) moderate-intensity endurance exercise training did not favorably alter bone turnover and had no impact on BMD; and (3) there were no additive effects of soy and exercise on bone turnover or BMD.

Authors+Show Affiliations

Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. elevans@uiuc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17213752

Citation

Evans, Ellen M., et al. "Effects of Soy Protein Isolate and Moderate Exercise On Bone Turnover and Bone Mineral Density in Postmenopausal Women." Menopause (New York, N.Y.), vol. 14, no. 3 Pt 1, 2007, pp. 481-8.
Evans EM, Racette SB, Van Pelt RE, et al. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause. 2007;14(3 Pt 1):481-8.
Evans, E. M., Racette, S. B., Van Pelt, R. E., Peterson, L. R., & Villareal, D. T. (2007). Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause (New York, N.Y.), 14(3 Pt 1), pp. 481-8.
Evans EM, et al. Effects of Soy Protein Isolate and Moderate Exercise On Bone Turnover and Bone Mineral Density in Postmenopausal Women. Menopause. 2007;14(3 Pt 1):481-8. PubMed PMID: 17213752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. AU - Evans,Ellen M, AU - Racette,Susan B, AU - Van Pelt,Rachael E, AU - Peterson,Linda R, AU - Villareal,Dennis T, PY - 2007/1/11/pubmed PY - 2007/7/13/medline PY - 2007/1/11/entrez SP - 481 EP - 8 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 3 Pt 1 N2 - OBJECTIVE: The aim of this study was to assess the independent and additive effects of soy protein isolate (SPI) and moderate-intensity exercise (EX) on bone turnover and bone mineral density (BMD). DESIGN: This study used a placebo-controlled, double-blind (soy), randomized 2 (SPI vs milk protein isolate [MPI]) x 2 (EX vs no EX) design. Sixty-one postmenopausal women were randomized, and 43 (62 +/- 5 y) completed the 9-month intervention (SPI, n = 10; MPI, n = 12; SPI + EX, n = 11; MPI + EX, n = 10). Serum C-terminal cross-linked telopeptides of type I collagen and serum bone-specific alkaline phosphatase were measured as markers of bone resorption and formation, respectively. BMD was measured by dual-energy x-ray absorptiometry. RESULTS: At 9 months, SPI reduced serum C-terminal cross-linked telopeptides (-13.3% +/- 15.3% vs -1.5% +/- 21.0%; P = 0.02) and serum bone-specific alkaline phosphatase (-4.7% +/- 14.7% vs 6.5% +/- 17.7%; P = 0.02) compared to milk protein isolate. EX attenuated the reduction in serum C-terminal cross-linked telopeptides (-1.9% +/- 21.6% vs -12.4% +/- 15.3%; P = 0.04); however, no EX effects were apparent in serum bone-specific alkaline phosphatase at 9 months (2.8% +/- 16.1% vs -1.0% +/- 18.3%; P = 0.28). Neither SPI nor EX affected BMD at any site; however, change in BMD was related to change in fat mass (r = 0.40, P < 0.05). CONCLUSIONS: In postmenopausal women (1) SPI reduces bone turnover with no impact on BMD over 9 months; (2) moderate-intensity endurance exercise training did not favorably alter bone turnover and had no impact on BMD; and (3) there were no additive effects of soy and exercise on bone turnover or BMD. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17213752/Effects_of_soy_protein_isolate_and_moderate_exercise_on_bone_turnover_and_bone_mineral_density_in_postmenopausal_women_ L2 - http://dx.doi.org/10.1097/01.gme.0000243570.78570.f7 DB - PRIME DP - Unbound Medicine ER -