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Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women.

Abstract

OBJECTIVE

The aim of this study was to assess the independent and additive effects of soy protein isolate (SPI) and moderate-intensity exercise (EX) on bone turnover and bone mineral density (BMD).

DESIGN

This study used a placebo-controlled, double-blind (soy), randomized 2 (SPI vs milk protein isolate [MPI]) x 2 (EX vs no EX) design. Sixty-one postmenopausal women were randomized, and 43 (62 +/- 5 y) completed the 9-month intervention (SPI, n = 10; MPI, n = 12; SPI + EX, n = 11; MPI + EX, n = 10). Serum C-terminal cross-linked telopeptides of type I collagen and serum bone-specific alkaline phosphatase were measured as markers of bone resorption and formation, respectively. BMD was measured by dual-energy x-ray absorptiometry.

RESULTS

At 9 months, SPI reduced serum C-terminal cross-linked telopeptides (-13.3% +/- 15.3% vs -1.5% +/- 21.0%; P = 0.02) and serum bone-specific alkaline phosphatase (-4.7% +/- 14.7% vs 6.5% +/- 17.7%; P = 0.02) compared to milk protein isolate. EX attenuated the reduction in serum C-terminal cross-linked telopeptides (-1.9% +/- 21.6% vs -12.4% +/- 15.3%; P = 0.04); however, no EX effects were apparent in serum bone-specific alkaline phosphatase at 9 months (2.8% +/- 16.1% vs -1.0% +/- 18.3%; P = 0.28). Neither SPI nor EX affected BMD at any site; however, change in BMD was related to change in fat mass (r = 0.40, P < 0.05).

CONCLUSIONS

In postmenopausal women (1) SPI reduces bone turnover with no impact on BMD over 9 months; (2) moderate-intensity endurance exercise training did not favorably alter bone turnover and had no impact on BMD; and (3) there were no additive effects of soy and exercise on bone turnover or BMD.

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  • Authors+Show Affiliations

    ,

    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. elevans@uiuc.edu

    , , ,

    Source

    Menopause (New York, N.Y.) 14:3 Pt 1 pg 481-8

    MeSH

    Absorptiometry, Photon
    Aged
    Bone Density
    Bone Remodeling
    Double-Blind Method
    Exercise
    Female
    Humans
    Isoflavones
    Middle Aged
    Osteoporosis, Postmenopausal
    Postmenopause
    Soybean Proteins
    Treatment Outcome
    Women's Health

    Pub Type(s)

    Controlled Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17213752

    Citation

    Evans, Ellen M., et al. "Effects of Soy Protein Isolate and Moderate Exercise On Bone Turnover and Bone Mineral Density in Postmenopausal Women." Menopause (New York, N.Y.), vol. 14, no. 3 Pt 1, 2007, pp. 481-8.
    Evans EM, Racette SB, Van Pelt RE, et al. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause. 2007;14(3 Pt 1):481-8.
    Evans, E. M., Racette, S. B., Van Pelt, R. E., Peterson, L. R., & Villareal, D. T. (2007). Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause (New York, N.Y.), 14(3 Pt 1), pp. 481-8.
    Evans EM, et al. Effects of Soy Protein Isolate and Moderate Exercise On Bone Turnover and Bone Mineral Density in Postmenopausal Women. Menopause. 2007;14(3 Pt 1):481-8. PubMed PMID: 17213752.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. AU - Evans,Ellen M, AU - Racette,Susan B, AU - Van Pelt,Rachael E, AU - Peterson,Linda R, AU - Villareal,Dennis T, PY - 2007/1/11/pubmed PY - 2007/7/13/medline PY - 2007/1/11/entrez SP - 481 EP - 8 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 3 Pt 1 N2 - OBJECTIVE: The aim of this study was to assess the independent and additive effects of soy protein isolate (SPI) and moderate-intensity exercise (EX) on bone turnover and bone mineral density (BMD). DESIGN: This study used a placebo-controlled, double-blind (soy), randomized 2 (SPI vs milk protein isolate [MPI]) x 2 (EX vs no EX) design. Sixty-one postmenopausal women were randomized, and 43 (62 +/- 5 y) completed the 9-month intervention (SPI, n = 10; MPI, n = 12; SPI + EX, n = 11; MPI + EX, n = 10). Serum C-terminal cross-linked telopeptides of type I collagen and serum bone-specific alkaline phosphatase were measured as markers of bone resorption and formation, respectively. BMD was measured by dual-energy x-ray absorptiometry. RESULTS: At 9 months, SPI reduced serum C-terminal cross-linked telopeptides (-13.3% +/- 15.3% vs -1.5% +/- 21.0%; P = 0.02) and serum bone-specific alkaline phosphatase (-4.7% +/- 14.7% vs 6.5% +/- 17.7%; P = 0.02) compared to milk protein isolate. EX attenuated the reduction in serum C-terminal cross-linked telopeptides (-1.9% +/- 21.6% vs -12.4% +/- 15.3%; P = 0.04); however, no EX effects were apparent in serum bone-specific alkaline phosphatase at 9 months (2.8% +/- 16.1% vs -1.0% +/- 18.3%; P = 0.28). Neither SPI nor EX affected BMD at any site; however, change in BMD was related to change in fat mass (r = 0.40, P < 0.05). CONCLUSIONS: In postmenopausal women (1) SPI reduces bone turnover with no impact on BMD over 9 months; (2) moderate-intensity endurance exercise training did not favorably alter bone turnover and had no impact on BMD; and (3) there were no additive effects of soy and exercise on bone turnover or BMD. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17213752/Effects_of_soy_protein_isolate_and_moderate_exercise_on_bone_turnover_and_bone_mineral_density_in_postmenopausal_women_ L2 - http://Insights.ovid.com/pubmed?pmid=17213752 DB - PRIME DP - Unbound Medicine ER -