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Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala.
Neuropsychopharmacology. 2007 Sep; 32(9):1929-40.N

Abstract

N-methyl-D-aspartate receptors (NMDARs) contribute to synaptic plasticity underlying learning in a variety of brain systems. Fear extinction, which involves learning to suppress the expression of previously learned fear, appears to require NMDAR activation in the amygdala. However, it is unclear whether amygdala NMDARs are required for the acquisition of extinction learning, and it is unknown whether NR2B-containing NMDARs are required in fear extinction. Here, we assessed the effects of selective NR2B blockade with ifenprodil on fear extinction learning, and found that both systemic and intra-amygdala ifenprodil treatment, given before extinction training, impaired the initial acquisition, and subsequent retrieval of fear extinction. These results confirm previous evidence showing that NMDARs in the amygdala are involved in fear extinction, and additionally show that NR2B-containing NMDARs are required. Contrary to the conclusion of previous studies, our findings demonstrate NMDARs are required for the initial acquisition, rather than only the retention, of fear extinction learning. Thus, our results support a previously not known role for NMDA-dependent plasticity in the lateral amygdala during the acquisition of fear extinction.

Authors+Show Affiliations

Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA. fsotres@cns.nyu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17213844

Citation

Sotres-Bayon, Francisco, et al. "Acquisition of Fear Extinction Requires Activation of NR2B-containing NMDA Receptors in the Lateral Amygdala." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 32, no. 9, 2007, pp. 1929-40.
Sotres-Bayon F, Bush DE, LeDoux JE. Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology. 2007;32(9):1929-40.
Sotres-Bayon, F., Bush, D. E., & LeDoux, J. E. (2007). Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 32(9), 1929-40.
Sotres-Bayon F, Bush DE, LeDoux JE. Acquisition of Fear Extinction Requires Activation of NR2B-containing NMDA Receptors in the Lateral Amygdala. Neuropsychopharmacology. 2007;32(9):1929-40. PubMed PMID: 17213844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. AU - Sotres-Bayon,Francisco, AU - Bush,David E A, AU - LeDoux,Joseph E, Y1 - 2007/01/10/ PY - 2007/1/11/pubmed PY - 2007/12/6/medline PY - 2007/1/11/entrez SP - 1929 EP - 40 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 32 IS - 9 N2 - N-methyl-D-aspartate receptors (NMDARs) contribute to synaptic plasticity underlying learning in a variety of brain systems. Fear extinction, which involves learning to suppress the expression of previously learned fear, appears to require NMDAR activation in the amygdala. However, it is unclear whether amygdala NMDARs are required for the acquisition of extinction learning, and it is unknown whether NR2B-containing NMDARs are required in fear extinction. Here, we assessed the effects of selective NR2B blockade with ifenprodil on fear extinction learning, and found that both systemic and intra-amygdala ifenprodil treatment, given before extinction training, impaired the initial acquisition, and subsequent retrieval of fear extinction. These results confirm previous evidence showing that NMDARs in the amygdala are involved in fear extinction, and additionally show that NR2B-containing NMDARs are required. Contrary to the conclusion of previous studies, our findings demonstrate NMDARs are required for the initial acquisition, rather than only the retention, of fear extinction learning. Thus, our results support a previously not known role for NMDA-dependent plasticity in the lateral amygdala during the acquisition of fear extinction. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/17213844/Acquisition_of_fear_extinction_requires_activation_of_NR2B_containing_NMDA_receptors_in_the_lateral_amygdala_ DB - PRIME DP - Unbound Medicine ER -