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Hyperhomocysteinemia as a cardiovascular risk factor in Indian women: determinants and directionality.
J Assoc Physicians India. 2006 Oct; 54:769-74.JA

Abstract

OBJECTIVE

To assess Homocysteine (Hcy), vitamin B12 and folic acid (FA) concentrations in resident Indian women and to study their correlation with traditional risk factors for coronary artery disease.

MATERIAL AND METHODS

The study included 137 consecutive women who attended a health care program (HCP) for women at and above 40 years of age (MAITREYI's HCP). Fasting blood samples for Hcy, B12 and folate were collected on ice, centrifuged within 1/2 hour and stored at -70 degrees C till assayed using a chemiluminescence method. All women underwent a screening for their general health profile including cardiovascular health.

RESULTS

Of the 137 women screened 21 were excluded because of presence of factors known to affect Hcy levels (history of existing CAD had hypothyroidism or were on multivitamin supplements). The median Hcy, folic acid and vitamin B12 levels were 9 pmol/L (range 4.2-38.6), 8.8 ng/ml (2.3-31.6 range) and 214 pg/ml (100-2400 range) respectively. The prevalence of hyperhomocysteinemia (>15 pmol/L) was 24.2%. Correlation for continuous variables using spearman's test and for categorical variables with chi-square test showed a highly significant negative correlation with vitamin B12 (p < 0.001) and FA (p<0.002). Both systolic (p < 0.05) and diastolic (p < 0.02) and diastolic blood pressure also showed a significant correlation. However, no correlation was found between plasma Hcy and blood sugars, lipids, age, body mass index and menopausal status. The CAD risk was assessed using Framingham risk scores and this too did not show a correlation with plasma Hcy.

CONCLUSIONS

A large number of women from the present study had hyperhomocysteinemia and were deficient in vitamin B12. A significant negative correlation between vitamin B12 and plasma Hcy levels was foundin these older women. Most Indian studies including the present one do not show a positive correlation between elevated Hcy levels and CAD in spite of a large percentage of persons showing elevated homocysteine levels. Since high Hcy levels are recognized as an independent risk factor for CAD, these findings of absence of correlation between Hcy and CAD as reported in various Indian studies need to be explored and explained.

Authors+Show Affiliations

Bhavan's SPARC, JVPD Scheme, Mumbai.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17214272

Citation

Pandey, S N., et al. "Hyperhomocysteinemia as a Cardiovascular Risk Factor in Indian Women: Determinants and Directionality." The Journal of the Association of Physicians of India, vol. 54, 2006, pp. 769-74.
Pandey SN, Vaidya AD, Vaidya RA, et al. Hyperhomocysteinemia as a cardiovascular risk factor in Indian women: determinants and directionality. J Assoc Physicians India. 2006;54:769-74.
Pandey, S. N., Vaidya, A. D., Vaidya, R. A., & Talwalkar, S. (2006). Hyperhomocysteinemia as a cardiovascular risk factor in Indian women: determinants and directionality. The Journal of the Association of Physicians of India, 54, 769-74.
Pandey SN, et al. Hyperhomocysteinemia as a Cardiovascular Risk Factor in Indian Women: Determinants and Directionality. J Assoc Physicians India. 2006;54:769-74. PubMed PMID: 17214272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinemia as a cardiovascular risk factor in Indian women: determinants and directionality. AU - Pandey,S N, AU - Vaidya,A D B, AU - Vaidya,R A, AU - Talwalkar,S, PY - 2007/1/12/pubmed PY - 2007/2/9/medline PY - 2007/1/12/entrez SP - 769 EP - 74 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 54 N2 - OBJECTIVE: To assess Homocysteine (Hcy), vitamin B12 and folic acid (FA) concentrations in resident Indian women and to study their correlation with traditional risk factors for coronary artery disease. MATERIAL AND METHODS: The study included 137 consecutive women who attended a health care program (HCP) for women at and above 40 years of age (MAITREYI's HCP). Fasting blood samples for Hcy, B12 and folate were collected on ice, centrifuged within 1/2 hour and stored at -70 degrees C till assayed using a chemiluminescence method. All women underwent a screening for their general health profile including cardiovascular health. RESULTS: Of the 137 women screened 21 were excluded because of presence of factors known to affect Hcy levels (history of existing CAD had hypothyroidism or were on multivitamin supplements). The median Hcy, folic acid and vitamin B12 levels were 9 pmol/L (range 4.2-38.6), 8.8 ng/ml (2.3-31.6 range) and 214 pg/ml (100-2400 range) respectively. The prevalence of hyperhomocysteinemia (>15 pmol/L) was 24.2%. Correlation for continuous variables using spearman's test and for categorical variables with chi-square test showed a highly significant negative correlation with vitamin B12 (p < 0.001) and FA (p<0.002). Both systolic (p < 0.05) and diastolic (p < 0.02) and diastolic blood pressure also showed a significant correlation. However, no correlation was found between plasma Hcy and blood sugars, lipids, age, body mass index and menopausal status. The CAD risk was assessed using Framingham risk scores and this too did not show a correlation with plasma Hcy. CONCLUSIONS: A large number of women from the present study had hyperhomocysteinemia and were deficient in vitamin B12. A significant negative correlation between vitamin B12 and plasma Hcy levels was foundin these older women. Most Indian studies including the present one do not show a positive correlation between elevated Hcy levels and CAD in spite of a large percentage of persons showing elevated homocysteine levels. Since high Hcy levels are recognized as an independent risk factor for CAD, these findings of absence of correlation between Hcy and CAD as reported in various Indian studies need to be explored and explained. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/17214272/Hyperhomocysteinemia_as_a_cardiovascular_risk_factor_in_Indian_women:_determinants_and_directionality_ L2 - https://antibodies.cancer.gov/detail/CPTC-FANCA-1 DB - PRIME DP - Unbound Medicine ER -