Tags

Type your tag names separated by a space and hit enter

Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis.
J Cutan Pathol 2007; 34(1):27-32JC

Abstract

Patients with mucocutaneous leishmaniasis (MCL) show a vigorous T-cell immune response against Leishmania braziliensis. Because the Th response is associated with inflammation, the non-functional CC chemokine receptor 5 (CCR5) may rely in a less severe inflammatory state. The aim of this study was to investigate the CCR5 gene in a Brazilian population with leishmaniasis compared with healthy control subjects and to determine the progression from cutaneous to MCL in the Delta32 allele carriers. Among 100 patients with Montenegro skin test and indirect immunofluorescence assay (IIF) values positive for leishmaniasis, there were 32% women and 68% men. The patients were 89% CCR5/CCR5, 10% CCR5/Delta32, and 1% Delta32/Delta32, while healthy subjects showed a 91% incidence of CCR5/CCR5, 8% of CCR5/Delta32, and 1% of Delta32/Delta32. The CCR5/CCR5 patients (89%) showed a large spectrum of clinical manifestations, where 22.47% had active mucous lesions and 77.53% had cutaneous lesions. In this work, the Delta32 allele carriers (10%) showed only cutaneous manifestations when compared with wild-type individuals. Finally, with regard to the Delta32 allele carriers, a less severe spectrum of clinical manifestations was observed in comparison with wild-type individuals. Although a lack of mucocutaneous lesions was evident among Delta32 allele carriers, the number of individuals studied was small. Therefore, further investigations are needed to elucidate the role of CCR5 in the clinical aspects of leishmaniasis.

Authors+Show Affiliations

Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, Parana, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17214851

Citation

Brajão de Oliveira, Karen, et al. "Analysis of the CC Chemokine Receptor 5 Delta32 Polymorphism in a Brazilian Population With Cutaneous Leishmaniasis." Journal of Cutaneous Pathology, vol. 34, no. 1, 2007, pp. 27-32.
Brajão de Oliveira K, Reiche EM, Kaminami Morimoto H, et al. Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis. J Cutan Pathol. 2007;34(1):27-32.
Brajão de Oliveira, K., Reiche, E. M., Kaminami Morimoto, H., Pelegrinelli Fungaro, M. H., Estevão, D., Pontello, R., ... Watanabe, M. A. (2007). Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis. Journal of Cutaneous Pathology, 34(1), pp. 27-32.
Brajão de Oliveira K, et al. Analysis of the CC Chemokine Receptor 5 Delta32 Polymorphism in a Brazilian Population With Cutaneous Leishmaniasis. J Cutan Pathol. 2007;34(1):27-32. PubMed PMID: 17214851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis. AU - Brajão de Oliveira,Karen, AU - Reiche,Edna Maria Vissoci, AU - Kaminami Morimoto,Helena, AU - Pelegrinelli Fungaro,Maria Helena, AU - Estevão,Dirceu, AU - Pontello,Rubens, AU - Franco Nasser,Thiago, AU - Watanabe,Maria Angelica Ehara, PY - 2007/1/12/pubmed PY - 2007/3/21/medline PY - 2007/1/12/entrez SP - 27 EP - 32 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 34 IS - 1 N2 - Patients with mucocutaneous leishmaniasis (MCL) show a vigorous T-cell immune response against Leishmania braziliensis. Because the Th response is associated with inflammation, the non-functional CC chemokine receptor 5 (CCR5) may rely in a less severe inflammatory state. The aim of this study was to investigate the CCR5 gene in a Brazilian population with leishmaniasis compared with healthy control subjects and to determine the progression from cutaneous to MCL in the Delta32 allele carriers. Among 100 patients with Montenegro skin test and indirect immunofluorescence assay (IIF) values positive for leishmaniasis, there were 32% women and 68% men. The patients were 89% CCR5/CCR5, 10% CCR5/Delta32, and 1% Delta32/Delta32, while healthy subjects showed a 91% incidence of CCR5/CCR5, 8% of CCR5/Delta32, and 1% of Delta32/Delta32. The CCR5/CCR5 patients (89%) showed a large spectrum of clinical manifestations, where 22.47% had active mucous lesions and 77.53% had cutaneous lesions. In this work, the Delta32 allele carriers (10%) showed only cutaneous manifestations when compared with wild-type individuals. Finally, with regard to the Delta32 allele carriers, a less severe spectrum of clinical manifestations was observed in comparison with wild-type individuals. Although a lack of mucocutaneous lesions was evident among Delta32 allele carriers, the number of individuals studied was small. Therefore, further investigations are needed to elucidate the role of CCR5 in the clinical aspects of leishmaniasis. SN - 0303-6987 UR - https://www.unboundmedicine.com/medline/citation/17214851/Analysis_of_the_CC_chemokine_receptor_5_delta32_polymorphism_in_a_Brazilian_population_with_cutaneous_leishmaniasis_ L2 - https://doi.org/10.1111/j.1600-0560.2006.00573.x DB - PRIME DP - Unbound Medicine ER -