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Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study.
Am J Epidemiol. 2007 Apr 01; 165(7):784-93.AJ

Abstract

The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996, 85,903 men and 105,108 women aged > or =45 years completed a quantitative food frequency questionnaire. A total of 2,110 incident cases of colorectal cancer (1,138 in men and 972 in women) were identified through December 31, 2001. Cox proportional hazards models were used to calculate multivariate-adjusted relative risks and 95% confidence intervals. Total calcium intake (from foods and supplements) was inversely associated with colorectal cancer risk in both men (highest quintile vs. lowest: relative risk (RR) = 0.70, 95% confidence interval (CI): 0.52, 0.93; p for trend = 0.006) and women (RR = 0.64, 95% CI: 0.50, 0.83; p for trend = 0.003). The inverse association was also seen for total vitamin D intake in men (RR = 0.72, 95% CI: 0.51, 1.00; p for trend = 0.03) but not in women. Intake of dairy products was inversely associated with colorectal cancer risk, especially among nonusers of supplemental calcium (men: RR = 0.77, 95% CI: 0.59, 1.01; women: RR = 0.66, 95% CI: 0.49, 0.89). The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer.

Authors+Show Affiliations

Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA. spark@crch.hawaii.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17215380

Citation

Park, Song-Yi, et al. "Calcium and Vitamin D Intake and Risk of Colorectal Cancer: the Multiethnic Cohort Study." American Journal of Epidemiology, vol. 165, no. 7, 2007, pp. 784-93.
Park SY, Murphy SP, Wilkens LR, et al. Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. Am J Epidemiol. 2007;165(7):784-93.
Park, S. Y., Murphy, S. P., Wilkens, L. R., Nomura, A. M., Henderson, B. E., & Kolonel, L. N. (2007). Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. American Journal of Epidemiology, 165(7), 784-93.
Park SY, et al. Calcium and Vitamin D Intake and Risk of Colorectal Cancer: the Multiethnic Cohort Study. Am J Epidemiol. 2007 Apr 1;165(7):784-93. PubMed PMID: 17215380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. AU - Park,Song-Yi, AU - Murphy,Suzanne P, AU - Wilkens,Lynne R, AU - Nomura,Abraham M Y, AU - Henderson,Brian E, AU - Kolonel,Laurence N, Y1 - 2007/01/10/ PY - 2007/1/12/pubmed PY - 2007/5/4/medline PY - 2007/1/12/entrez SP - 784 EP - 93 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 165 IS - 7 N2 - The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996, 85,903 men and 105,108 women aged > or =45 years completed a quantitative food frequency questionnaire. A total of 2,110 incident cases of colorectal cancer (1,138 in men and 972 in women) were identified through December 31, 2001. Cox proportional hazards models were used to calculate multivariate-adjusted relative risks and 95% confidence intervals. Total calcium intake (from foods and supplements) was inversely associated with colorectal cancer risk in both men (highest quintile vs. lowest: relative risk (RR) = 0.70, 95% confidence interval (CI): 0.52, 0.93; p for trend = 0.006) and women (RR = 0.64, 95% CI: 0.50, 0.83; p for trend = 0.003). The inverse association was also seen for total vitamin D intake in men (RR = 0.72, 95% CI: 0.51, 1.00; p for trend = 0.03) but not in women. Intake of dairy products was inversely associated with colorectal cancer risk, especially among nonusers of supplemental calcium (men: RR = 0.77, 95% CI: 0.59, 1.01; women: RR = 0.66, 95% CI: 0.49, 0.89). The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17215380/Calcium_and_vitamin_D_intake_and_risk_of_colorectal_cancer:_the_Multiethnic_Cohort_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwk069 DB - PRIME DP - Unbound Medicine ER -