TY - JOUR T1 - Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. AU - Park,Song-Yi, AU - Murphy,Suzanne P, AU - Wilkens,Lynne R, AU - Nomura,Abraham M Y, AU - Henderson,Brian E, AU - Kolonel,Laurence N, Y1 - 2007/01/10/ PY - 2007/1/12/pubmed PY - 2007/5/4/medline PY - 2007/1/12/entrez SP - 784 EP - 93 JF - American journal of epidemiology JO - Am J Epidemiol VL - 165 IS - 7 N2 - The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996, 85,903 men and 105,108 women aged > or =45 years completed a quantitative food frequency questionnaire. A total of 2,110 incident cases of colorectal cancer (1,138 in men and 972 in women) were identified through December 31, 2001. Cox proportional hazards models were used to calculate multivariate-adjusted relative risks and 95% confidence intervals. Total calcium intake (from foods and supplements) was inversely associated with colorectal cancer risk in both men (highest quintile vs. lowest: relative risk (RR) = 0.70, 95% confidence interval (CI): 0.52, 0.93; p for trend = 0.006) and women (RR = 0.64, 95% CI: 0.50, 0.83; p for trend = 0.003). The inverse association was also seen for total vitamin D intake in men (RR = 0.72, 95% CI: 0.51, 1.00; p for trend = 0.03) but not in women. Intake of dairy products was inversely associated with colorectal cancer risk, especially among nonusers of supplemental calcium (men: RR = 0.77, 95% CI: 0.59, 1.01; women: RR = 0.66, 95% CI: 0.49, 0.89). The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17215380/Calcium_and_vitamin_D_intake_and_risk_of_colorectal_cancer:_the_Multiethnic_Cohort_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwk069 DB - PRIME DP - Unbound Medicine ER -