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Differences in 24-hour urine composition between black and white women.

Abstract

Black women are less likely to develop kidney stones and have greater bone mass than white women. However, little is known about racial differences in urine composition. Urine pH, volume, and 24-h urinary excretion of calcium, citrate, oxalate, uric acid, sodium, potassium, magnesium, phosphate, sulfate, and creatinine of 146 black women were compared with 330 white women in the Nurses' Health Study. All participants were postmenopausal non-stone formers. ANOVA was used to compare mean urinary values. Linear regression models were adjusted for age, body mass index, dietary intake, and urinary factors. On average, black women excreted 65 mg less urinary calcium (P < 0.001), 4 mg more oxalate (P < 0.001), 9 mEq less potassium (P < 0.001), 11 mg less magnesium (P = 0.003), 120 mg less phosphate (P < 0.001), and 3 mmol less sulfate (P < 0.001) per day than did white women. The urine pH of black women was 0.11 units higher (P = 0.03) and urine volume was 0.24 L less (P = 0.001). The urinary relative supersaturations of calcium oxalate (P = 0.03) and brushite (P = 0.002) were lower in black women. No other significant differences were observed. Differences in urinary calcium and pH persisted after multivariate adjustment and after exclusion of participants who were taking thiazide diuretics or those with diabetes. In conclusion, black women excrete less urinary calcium and have a higher urinary pH than do white women. These differences are not explained by differences in age, body mass index, or diet and may account for the lower incidence of both nephrolithiasis and osteoporosis in black women.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Third Floor, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA. entaylor@partners.org

    Source

    MeSH

    African Continental Ancestry Group
    Aged
    Body Mass Index
    Continental Population Groups
    Creatinine
    Dietary Supplements
    European Continental Ancestry Group
    Female
    Humans
    Metals
    Middle Aged
    Phosphates
    Sulfates
    Urinalysis

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17215441

    Citation

    Taylor, Eric N., and Gary C. Curhan. "Differences in 24-hour Urine Composition Between Black and White Women." Journal of the American Society of Nephrology : JASN, vol. 18, no. 2, 2007, pp. 654-9.
    Taylor EN, Curhan GC. Differences in 24-hour urine composition between black and white women. J Am Soc Nephrol. 2007;18(2):654-9.
    Taylor, E. N., & Curhan, G. C. (2007). Differences in 24-hour urine composition between black and white women. Journal of the American Society of Nephrology : JASN, 18(2), pp. 654-9.
    Taylor EN, Curhan GC. Differences in 24-hour Urine Composition Between Black and White Women. J Am Soc Nephrol. 2007;18(2):654-9. PubMed PMID: 17215441.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Differences in 24-hour urine composition between black and white women. AU - Taylor,Eric N, AU - Curhan,Gary C, Y1 - 2007/01/10/ PY - 2007/1/12/pubmed PY - 2007/4/11/medline PY - 2007/1/12/entrez SP - 654 EP - 9 JF - Journal of the American Society of Nephrology : JASN JO - J. Am. Soc. Nephrol. VL - 18 IS - 2 N2 - Black women are less likely to develop kidney stones and have greater bone mass than white women. However, little is known about racial differences in urine composition. Urine pH, volume, and 24-h urinary excretion of calcium, citrate, oxalate, uric acid, sodium, potassium, magnesium, phosphate, sulfate, and creatinine of 146 black women were compared with 330 white women in the Nurses' Health Study. All participants were postmenopausal non-stone formers. ANOVA was used to compare mean urinary values. Linear regression models were adjusted for age, body mass index, dietary intake, and urinary factors. On average, black women excreted 65 mg less urinary calcium (P < 0.001), 4 mg more oxalate (P < 0.001), 9 mEq less potassium (P < 0.001), 11 mg less magnesium (P = 0.003), 120 mg less phosphate (P < 0.001), and 3 mmol less sulfate (P < 0.001) per day than did white women. The urine pH of black women was 0.11 units higher (P = 0.03) and urine volume was 0.24 L less (P = 0.001). The urinary relative supersaturations of calcium oxalate (P = 0.03) and brushite (P = 0.002) were lower in black women. No other significant differences were observed. Differences in urinary calcium and pH persisted after multivariate adjustment and after exclusion of participants who were taking thiazide diuretics or those with diabetes. In conclusion, black women excrete less urinary calcium and have a higher urinary pH than do white women. These differences are not explained by differences in age, body mass index, or diet and may account for the lower incidence of both nephrolithiasis and osteoporosis in black women. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/17215441/Differences_in_24_hour_urine_composition_between_black_and_white_women_ L2 - http://jasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=17215441 DB - PRIME DP - Unbound Medicine ER -