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TRPV channels' role in osmotransduction and mechanotransduction.

Abstract

In signal transduction of metazoan cells, transient receptor potential (TRP) ion channels have been identified that respond to diverse external and internal stimuli, among them osmotic and mechanical stimuli. This chapter will summarize findings on the TRPV subfamily, both its vertebrate and invertebrate members. Of the six mammalian TRPV channels, TRPV1, -V2, and -V4 were demonstrated to function in transduction of osmotic and/or mechanical stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic stimuli in C. elegans. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue mechanosensory and osmosensory deficits of the TRPV mutant line osm-9 in C. elegans, despite no more than 26% orthology of the respective amino acid sequences.

Authors+Show Affiliations

Center for Translational Neuroscience, Duke University, Durham, NC 27710, USA. wolfgang@neuro.duke.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17217074

Citation

Liedtke, W. "TRPV Channels' Role in Osmotransduction and Mechanotransduction." Handbook of Experimental Pharmacology, 2007, pp. 473-87.
Liedtke W. TRPV channels' role in osmotransduction and mechanotransduction. Handb Exp Pharmacol. 2007.
Liedtke, W. (2007). TRPV channels' role in osmotransduction and mechanotransduction. Handbook of Experimental Pharmacology, (179), 473-87.
Liedtke W. TRPV Channels' Role in Osmotransduction and Mechanotransduction. Handb Exp Pharmacol. 2007;(179)473-87. PubMed PMID: 17217074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRPV channels' role in osmotransduction and mechanotransduction. A1 - Liedtke,W, PY - 2007/1/16/pubmed PY - 2007/1/27/medline PY - 2007/1/16/entrez SP - 473 EP - 87 JF - Handbook of experimental pharmacology JO - Handb Exp Pharmacol IS - 179 N2 - In signal transduction of metazoan cells, transient receptor potential (TRP) ion channels have been identified that respond to diverse external and internal stimuli, among them osmotic and mechanical stimuli. This chapter will summarize findings on the TRPV subfamily, both its vertebrate and invertebrate members. Of the six mammalian TRPV channels, TRPV1, -V2, and -V4 were demonstrated to function in transduction of osmotic and/or mechanical stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic stimuli in C. elegans. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue mechanosensory and osmosensory deficits of the TRPV mutant line osm-9 in C. elegans, despite no more than 26% orthology of the respective amino acid sequences. SN - 0171-2004 UR - https://www.unboundmedicine.com/medline/citation/17217074/TRPV_channels'_role_in_osmotransduction_and_mechanotransduction_ L2 - https://dx.doi.org/10.1007/978-3-540-34891-7_28 DB - PRIME DP - Unbound Medicine ER -