Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease.
J Neurochem. 2007 Feb; 100(4):874-82.JN

Abstract

Neurodegenerative diseases such as Huntington's disease and Alzheimer's disease, although very different in etiology, share common degenerative processes. These include neuronal dysfunction, decreased neural connectivity, and disruption of cellular plasticity. Understanding the molecular mechanisms underlying the neural plasticity deficits in these devastating conditions may lead the way toward new therapeutic targets, both disease-specific and more generalized, which can ameliorate degenerative cognitive deficits. Furthermore, investigations of 'pathological plasticity' in these diseases lend insight into normal brain function. This review will present evidence for altered plasticity in Huntington's and Alzheimer's diseases, relate these findings to symptomatology, and review possible causes and commonalities.

Authors+Show Affiliations

Spires TL

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.

Hannan AJ

No affiliation info available

MeSH

Alzheimer DiseaseAnimalsHumansHuntington DiseaseNeuronal Plasticity

Pub Type(s)

Journal Article

Research Support, N.I.H., Extramural

Research Support, Non-U.S. Gov't

Review

Language

eng

PubMed ID

17217424

Citation

Spires, Tara L., and Anthony J. Hannan. "Molecular Mechanisms Mediating Pathological Plasticity in Huntington's Disease and Alzheimer's Disease." Journal of Neurochemistry, vol. 100, no. 4, 2007, pp. 874-82.

Spires TL, Hannan AJ. Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease. J Neurochem. 2007;100(4):874-82.

Spires, T. L., & Hannan, A. J. (2007). Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease. Journal of Neurochemistry, 100(4), 874-82.

Spires TL, Hannan AJ. Molecular Mechanisms Mediating Pathological Plasticity in Huntington's Disease and Alzheimer's Disease. J Neurochem. 2007;100(4):874-82. PubMed PMID: 17217424.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease. AU - Spires,Tara L, AU - Hannan,Anthony J, Y1 - 2007/01/08/ PY - 2007/1/16/pubmed PY - 2007/4/11/medline PY - 2007/1/16/entrez SP - 874 EP - 82 JF - Journal of neurochemistry JO - J Neurochem VL - 100 IS - 4 N2 - Neurodegenerative diseases such as Huntington's disease and Alzheimer's disease, although very different in etiology, share common degenerative processes. These include neuronal dysfunction, decreased neural connectivity, and disruption of cellular plasticity. Understanding the molecular mechanisms underlying the neural plasticity deficits in these devastating conditions may lead the way toward new therapeutic targets, both disease-specific and more generalized, which can ameliorate degenerative cognitive deficits. Furthermore, investigations of 'pathological plasticity' in these diseases lend insight into normal brain function. This review will present evidence for altered plasticity in Huntington's and Alzheimer's diseases, relate these findings to symptomatology, and review possible causes and commonalities. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/17217424/Molecular_mechanisms_mediating_pathological_plasticity_in_Huntington's_disease_and_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -

Tags

Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease.J Neurochem. 2007 Feb; 100(4):874-82.JN