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Effects of cyanobacterial biomass on the Japanese quail.
Toxicon. 2007 May; 49(6):793-803.T

Abstract

Mortality of wild aquatic birds has recently been attributed to cyanobacterial toxins. Despite this, no experimental studies on the effects of defined doses of microcystins administered orally to birds exist. In this experiment, four groups of male Japanese quails daily ingesting 10ml of Microcystis biomass containing 0.045, 0.459, 4.605 or 46.044mug of microcystins, respectively, for 10 and 30 days, showed no mortality. Histopathological hepatic changes in birds after the biomass exposure included cloudy swelling of hepatocytes, vacuolar dystrophy, steatosis and hyperplasia of lymphatic centres. On subcellular level, shrunken nuclei of hepatocytes containing ring-like nucleoli, cristolysis within mitochondria and vacuoles with pseudomyelin structures were present. Vacuolar degeneration of the testicular germinative epithelium was found in two exposed males. Statistically significant differences in biochemical parameters were on day 10 of exposure only. They comprised increased activities of lactate dehydrogenase and a drop in blood glucose in birds receiving the highest dose of the biomass. Principal component analysis revealed a pattern of responses in biochemical parameters on day 10 that clearly separated the two greatest exposure groups from the controls and lower exposures. The results indicate that diagnosis of microcystin intoxication solely based on clinical biochemical and haematological parameters is hardly possible in birds.

Authors+Show Affiliations

Department of Veterinary Ecology and Environmental Protection, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1-3, Brno, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17217976

Citation

Skocovska, B, et al. "Effects of Cyanobacterial Biomass On the Japanese Quail." Toxicon : Official Journal of the International Society On Toxinology, vol. 49, no. 6, 2007, pp. 793-803.
Skocovska B, Hilscherova K, Babica P, et al. Effects of cyanobacterial biomass on the Japanese quail. Toxicon. 2007;49(6):793-803.
Skocovska, B., Hilscherova, K., Babica, P., Adamovsky, O., Bandouchova, H., Horakova, J., Knotkova, Z., Marsalek, B., Paskova, V., & Pikula, J. (2007). Effects of cyanobacterial biomass on the Japanese quail. Toxicon : Official Journal of the International Society On Toxinology, 49(6), 793-803.
Skocovska B, et al. Effects of Cyanobacterial Biomass On the Japanese Quail. Toxicon. 2007;49(6):793-803. PubMed PMID: 17217976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cyanobacterial biomass on the Japanese quail. AU - Skocovska,B, AU - Hilscherova,K, AU - Babica,P, AU - Adamovsky,O, AU - Bandouchova,H, AU - Horakova,J, AU - Knotkova,Z, AU - Marsalek,B, AU - Paskova,V, AU - Pikula,J, Y1 - 2006/12/08/ PY - 2006/09/22/received PY - 2006/11/29/revised PY - 2006/11/29/accepted PY - 2007/1/16/pubmed PY - 2007/7/21/medline PY - 2007/1/16/entrez SP - 793 EP - 803 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 49 IS - 6 N2 - Mortality of wild aquatic birds has recently been attributed to cyanobacterial toxins. Despite this, no experimental studies on the effects of defined doses of microcystins administered orally to birds exist. In this experiment, four groups of male Japanese quails daily ingesting 10ml of Microcystis biomass containing 0.045, 0.459, 4.605 or 46.044mug of microcystins, respectively, for 10 and 30 days, showed no mortality. Histopathological hepatic changes in birds after the biomass exposure included cloudy swelling of hepatocytes, vacuolar dystrophy, steatosis and hyperplasia of lymphatic centres. On subcellular level, shrunken nuclei of hepatocytes containing ring-like nucleoli, cristolysis within mitochondria and vacuoles with pseudomyelin structures were present. Vacuolar degeneration of the testicular germinative epithelium was found in two exposed males. Statistically significant differences in biochemical parameters were on day 10 of exposure only. They comprised increased activities of lactate dehydrogenase and a drop in blood glucose in birds receiving the highest dose of the biomass. Principal component analysis revealed a pattern of responses in biochemical parameters on day 10 that clearly separated the two greatest exposure groups from the controls and lower exposures. The results indicate that diagnosis of microcystin intoxication solely based on clinical biochemical and haematological parameters is hardly possible in birds. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/17217976/Effects_of_cyanobacterial_biomass_on_the_Japanese_quail_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(06)00461-2 DB - PRIME DP - Unbound Medicine ER -