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Prognosis of fibrotic interstitial pneumonia: idiopathic versus collagen vascular disease-related subtypes.
Am J Respir Crit Care Med. 2007 Apr 01; 175(7):705-11.AJ

Abstract

BACKGROUND

To investigate whether the better prognosis of interstitial pneumonias associated with collagen vascular disease (CVD) compared with idiopathic interstitial pneumonia (IIP) is due to higher frequency of the nonspecific interstitial pneumonia (NSIP) pattern in CVD, we compared the outcomes of patients from these two groups with the same histopathologic pattern.

SUBJECTS

The clinical features and survival of 362 patients (269 with IIP and 93 with CVD) diagnosed using surgical lung biopsy were analyzed.

RESULTS

The mean survival of the CVD group (131.0 mo) was longer than that of the IIP group (80.5 mo) (p<0.0001). The patients with usual interstitial pneumonia pattern among the CVD group (n=36) was younger, female, and predominantly nonsmoking compared with the IIP group (n=203). Although baseline lung functions were not significantly different, the CVD group survived longer (mean, 177.0 mo) than the IIP group (mean, 66.9 +/- 6.5 mo; p=0.001). By multivariate analysis, younger age, better pulmonary function, and the presence of a CVD were independent prognostic factors. In NSIP pattern, no significant differences in survival, clinical features, or lung function were found between the two groups.

CONCLUSION

Our data suggest that the better prognosis of patients in the CVD group is not solely due to the predominance of the NSIP pattern. The prognosis of patients with the usual interstitial pneumonia pattern in CVD is better than in those with idiopathic pulmonary fibrosis, despite the same pathologic pattern. In contrast, in those with an NSIP pattern, the prognosis is similar in both groups.

Authors+Show Affiliations

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Asan Medical Center, University of Ulsan, 388-1, Poongnap-dong, Songpa-gu, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17218621

Citation

Park, Joo Hun, et al. "Prognosis of Fibrotic Interstitial Pneumonia: Idiopathic Versus Collagen Vascular Disease-related Subtypes." American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 7, 2007, pp. 705-11.
Park JH, Kim DS, Park IN, et al. Prognosis of fibrotic interstitial pneumonia: idiopathic versus collagen vascular disease-related subtypes. Am J Respir Crit Care Med. 2007;175(7):705-11.
Park, J. H., Kim, D. S., Park, I. N., Jang, S. J., Kitaichi, M., Nicholson, A. G., & Colby, T. V. (2007). Prognosis of fibrotic interstitial pneumonia: idiopathic versus collagen vascular disease-related subtypes. American Journal of Respiratory and Critical Care Medicine, 175(7), 705-11.
Park JH, et al. Prognosis of Fibrotic Interstitial Pneumonia: Idiopathic Versus Collagen Vascular Disease-related Subtypes. Am J Respir Crit Care Med. 2007 Apr 1;175(7):705-11. PubMed PMID: 17218621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognosis of fibrotic interstitial pneumonia: idiopathic versus collagen vascular disease-related subtypes. AU - Park,Joo Hun, AU - Kim,Dong Soon, AU - Park,I-Nae, AU - Jang,Se Jin, AU - Kitaichi,Masanori, AU - Nicholson,Andrew G, AU - Colby,Thomas V, Y1 - 2007/01/11/ PY - 2007/1/16/pubmed PY - 2007/5/16/medline PY - 2007/1/16/entrez SP - 705 EP - 11 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 175 IS - 7 N2 - BACKGROUND: To investigate whether the better prognosis of interstitial pneumonias associated with collagen vascular disease (CVD) compared with idiopathic interstitial pneumonia (IIP) is due to higher frequency of the nonspecific interstitial pneumonia (NSIP) pattern in CVD, we compared the outcomes of patients from these two groups with the same histopathologic pattern. SUBJECTS: The clinical features and survival of 362 patients (269 with IIP and 93 with CVD) diagnosed using surgical lung biopsy were analyzed. RESULTS: The mean survival of the CVD group (131.0 mo) was longer than that of the IIP group (80.5 mo) (p<0.0001). The patients with usual interstitial pneumonia pattern among the CVD group (n=36) was younger, female, and predominantly nonsmoking compared with the IIP group (n=203). Although baseline lung functions were not significantly different, the CVD group survived longer (mean, 177.0 mo) than the IIP group (mean, 66.9 +/- 6.5 mo; p=0.001). By multivariate analysis, younger age, better pulmonary function, and the presence of a CVD were independent prognostic factors. In NSIP pattern, no significant differences in survival, clinical features, or lung function were found between the two groups. CONCLUSION: Our data suggest that the better prognosis of patients in the CVD group is not solely due to the predominance of the NSIP pattern. The prognosis of patients with the usual interstitial pneumonia pattern in CVD is better than in those with idiopathic pulmonary fibrosis, despite the same pathologic pattern. In contrast, in those with an NSIP pattern, the prognosis is similar in both groups. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/17218621/Prognosis_of_fibrotic_interstitial_pneumonia:_idiopathic_versus_collagen_vascular_disease_related_subtypes_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.200607-912OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -