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[Infection status and clinical significance of Epstein-Barr virus in pediatric leukemia---a report of 35 cases].
Ai Zheng. 2007 Jan; 26(1):54-7.AZ

Abstract

BACKGROUND & OBJECTIVE

Epstein-Barr virus (EBV) is associated with genesis of many human tumors. This study was to detect EBV infection in pediatric leukemia, and to explore its clinical significance.

METHODS

EBV DNA in peripheral blood mononuclear cells in 35 pediatric leukemia patients, including 26 cases of acute lymphoblastic leukemia (ALL) (24 received initial treatment and 2 received retreatment), 8 cases of acute non-lymphocytic leukemia (ANLL) and 1 case of chronic lymphocytic leukemia (CLL), and in 14 healthy children was detected by fluorescent quantitative polymerase chain reaction (FQ-PCR). Its clinical significance was analyzed according to the clinical manifestations, prednisone sensitivity test, and complete remission (CR) rate after induction chemotherapy.

RESULTS

EBV DNA was detected in 8 (22.86%) of the 35 pediatric leukemia patients. The positive rate of EBV DNA was 26.92% (7/26) in ALL with quantity of (5.144+/-6.91)x10(5) copies/ml, and 12.5% (1/8) in ANLL patients with quantity of 4.031x10(3) copies/ml. No EBV DNA was detected in CLL patients and healthy controls. The occurrence rates of peripheral leukocytosis and hepatosplenomegaly were significantly higher in the patients with EBV infection than in the patients without EBV infection (P <0.001). In ALL, the rate of no response to prednisone was significantly higher in the patients with EBV infection than in the patients without EBV infection (100% vs. 26.32%, P =0.001); CR rate after induction chemotherapy was significantly lower in the patients with EBV infection than in the patients without EBV infection (28.57% vs. 84.21%, P=0.003). In ANLL, the differences of CR rate and relapse rate were not significant between the patients with and without EBV infection (P=0.5).

CONCLUSIONS

Pediatric leukemia patients with EBV infection have higher incidence of peripheral leukocytosis and hepatosplenomegaly. ALL patients with EBV infection have poor prednisone response and low CR rate.

Authors+Show Affiliations

Lu Y
Department of Pediatrics, Affiliated Hospital, Medical College, Qingdao University, Qingdao, Shandong, 266003, P. R. China. luyuan6967@yahoo.com.cn
Sun LR
No affiliation info available
Pang XY
No affiliation info available
Lu ZH
No affiliation info available
Sui AH
No affiliation info available

MeSH

Antineoplastic Agents, HormonalChildChild, PreschoolDNA, ViralEpstein-Barr Virus InfectionsFemaleHepatomegalyHerpesvirus 4, HumanHumansInfantLeukemia, Lymphocytic, Chronic, B-CellLeukemia, Myeloid, AcuteLeukocytosisMalePrecursor Cell Lymphoblastic Leukemia-LymphomaPrednisoneRemission InductionSplenomegaly

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17222368

Citation

Lu, Yuan, et al. "[Infection Status and Clinical Significance of Epstein-Barr Virus in Pediatric Leukemia---a Report of 35 Cases]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 26, no. 1, 2007, pp. 54-7.
Lu Y, Sun LR, Pang XY, et al. [Infection status and clinical significance of Epstein-Barr virus in pediatric leukemia---a report of 35 cases]. Ai Zheng. 2007;26(1):54-7.
Lu, Y., Sun, L. R., Pang, X. Y., Lu, Z. H., & Sui, A. H. (2007). [Infection status and clinical significance of Epstein-Barr virus in pediatric leukemia---a report of 35 cases]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 26(1), 54-7.
Lu Y, et al. [Infection Status and Clinical Significance of Epstein-Barr Virus in Pediatric Leukemia---a Report of 35 Cases]. Ai Zheng. 2007;26(1):54-7. PubMed PMID: 17222368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Infection status and clinical significance of Epstein-Barr virus in pediatric leukemia---a report of 35 cases]. AU - Lu,Yuan, AU - Sun,Li-Rong, AU - Pang,Xiu-Ying, AU - Lu,Zhen-Hua, AU - Sui,Ai-Hua, PY - 2007/1/16/pubmed PY - 2009/9/25/medline PY - 2007/1/16/entrez SP - 54 EP - 7 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 26 IS - 1 N2 - BACKGROUND & OBJECTIVE: Epstein-Barr virus (EBV) is associated with genesis of many human tumors. This study was to detect EBV infection in pediatric leukemia, and to explore its clinical significance. METHODS: EBV DNA in peripheral blood mononuclear cells in 35 pediatric leukemia patients, including 26 cases of acute lymphoblastic leukemia (ALL) (24 received initial treatment and 2 received retreatment), 8 cases of acute non-lymphocytic leukemia (ANLL) and 1 case of chronic lymphocytic leukemia (CLL), and in 14 healthy children was detected by fluorescent quantitative polymerase chain reaction (FQ-PCR). Its clinical significance was analyzed according to the clinical manifestations, prednisone sensitivity test, and complete remission (CR) rate after induction chemotherapy. RESULTS: EBV DNA was detected in 8 (22.86%) of the 35 pediatric leukemia patients. The positive rate of EBV DNA was 26.92% (7/26) in ALL with quantity of (5.144+/-6.91)x10(5) copies/ml, and 12.5% (1/8) in ANLL patients with quantity of 4.031x10(3) copies/ml. No EBV DNA was detected in CLL patients and healthy controls. The occurrence rates of peripheral leukocytosis and hepatosplenomegaly were significantly higher in the patients with EBV infection than in the patients without EBV infection (P <0.001). In ALL, the rate of no response to prednisone was significantly higher in the patients with EBV infection than in the patients without EBV infection (100% vs. 26.32%, P =0.001); CR rate after induction chemotherapy was significantly lower in the patients with EBV infection than in the patients without EBV infection (28.57% vs. 84.21%, P=0.003). In ANLL, the differences of CR rate and relapse rate were not significant between the patients with and without EBV infection (P=0.5). CONCLUSIONS: Pediatric leukemia patients with EBV infection have higher incidence of peripheral leukocytosis and hepatosplenomegaly. ALL patients with EBV infection have poor prednisone response and low CR rate. UR - https://www.unboundmedicine.com/medline/citation/17222368/[Infection_status_and_clinical_significance_of_Epstein_Barr_virus_in_pediatric_leukemia___a_report_of_35_cases]_ DB - PRIME DP - Unbound Medicine ER -