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Dose- and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat.
Toxicology. 2007 Feb 28; 231(1):30-9.T

Abstract

This study investigates the dose- and time-dependent effects of sulfur mustard (SM) on antioxidant system and lipid peroxidation in liver and brain of rats. For this purpose, male Wistar rats were randomly divided into eight groups and treated as follows: group 1 as control and groups 2-8 as experimental groups that received SM (1-80 mg/kg) through intraperitoneal injection. Rats were killed after 2, 7 and 14 days of exposure. SM dose-dependently decreased body weight. Superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) activities in liver were significantly increased at SM doses lower than 10 mg/kg after 2 and 7 days of exposure. However, the recovery of these parameters was observed after 14 days. At these concentrations, no significant change in glutathione (GSH) and malondialdehyde (MDA) levels were observed. At doses higher than 10 mg/kg, SM significantly decreased SOD, CAT, glutathione peroxidase (GPX), and GST activities in liver and brain and decreased glutathione reductase (GR) activity in liver, which was associated with a depletion of GSH and increased MDA level. Present data indicate that the effect of SM is dose- and time-dependent and at higher doses (>10 mg/kg) induces an oxidative stress response by depleting the antioxidant defense systems and increasing lipid peroxidation in liver and brain of rats.

Authors+Show Affiliations

Department of Biochemistry and Research Center of Chemical Injuries, Faculty of Medicine, Baqiyatallah Medical Sciences University, Tehran, Iran. jafari@bmsu.ac.ir

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17222496

Citation

Jafari, Mahvash. "Dose- and Time-dependent Effects of Sulfur Mustard On Antioxidant System in Liver and Brain of Rat." Toxicology, vol. 231, no. 1, 2007, pp. 30-9.
Jafari M. Dose- and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat. Toxicology. 2007;231(1):30-9.
Jafari, M. (2007). Dose- and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat. Toxicology, 231(1), 30-9.
Jafari M. Dose- and Time-dependent Effects of Sulfur Mustard On Antioxidant System in Liver and Brain of Rat. Toxicology. 2007 Feb 28;231(1):30-9. PubMed PMID: 17222496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose- and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat. A1 - Jafari,Mahvash, Y1 - 2006/11/15/ PY - 2006/07/05/received PY - 2006/11/07/revised PY - 2006/11/08/accepted PY - 2007/1/16/pubmed PY - 2007/3/29/medline PY - 2007/1/16/entrez SP - 30 EP - 9 JF - Toxicology JO - Toxicology VL - 231 IS - 1 N2 - This study investigates the dose- and time-dependent effects of sulfur mustard (SM) on antioxidant system and lipid peroxidation in liver and brain of rats. For this purpose, male Wistar rats were randomly divided into eight groups and treated as follows: group 1 as control and groups 2-8 as experimental groups that received SM (1-80 mg/kg) through intraperitoneal injection. Rats were killed after 2, 7 and 14 days of exposure. SM dose-dependently decreased body weight. Superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) activities in liver were significantly increased at SM doses lower than 10 mg/kg after 2 and 7 days of exposure. However, the recovery of these parameters was observed after 14 days. At these concentrations, no significant change in glutathione (GSH) and malondialdehyde (MDA) levels were observed. At doses higher than 10 mg/kg, SM significantly decreased SOD, CAT, glutathione peroxidase (GPX), and GST activities in liver and brain and decreased glutathione reductase (GR) activity in liver, which was associated with a depletion of GSH and increased MDA level. Present data indicate that the effect of SM is dose- and time-dependent and at higher doses (>10 mg/kg) induces an oxidative stress response by depleting the antioxidant defense systems and increasing lipid peroxidation in liver and brain of rats. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17222496/Dose__and_time_dependent_effects_of_sulfur_mustard_on_antioxidant_system_in_liver_and_brain_of_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(06)00691-3 DB - PRIME DP - Unbound Medicine ER -