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Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents.
J Ethnopharmacol. 2007 May 22; 111(3):476-82.JE

Abstract

The rationale of this investigation was to examine the antinociceptive effect of an ethanol extract of Rosmarinus officinalis (RO) aerial parts, using three different experimental models: acetic acid-induced writhing test and formalin test in mice; and a model of arthritic pain: "pain-induced functional impairment model in the rat (PIFIR model)". The antinociceptive efficacies were evaluated using several dose-response curves and time courses. The antinociceptive effects from RO extract were compared with the antinociceptive effect of either tramadol (TR: 3.16-50 mg/kg, i.p. in mice, and 1.0-31.62 mg/kg, i.p. in rats) or acetylsalicylic acid (AA: 31.62-562.32 mg/kg, p.o.). RO extract (10-300 mg/kg, p.o.) significantly (P < 0.001) reduced the number of writhing movement induced by the i.p. administration of acetic acid solution in a dose-dependent way (ED50 = 108.84 mg/kg, whereas, TR showed an ED50 = 12.38 mg/kg). In addition, RO extract (30-300 mg/kg) significantly (P < 0.001) inhibited licking and shaking behaviours in both early (neurogenic pain) and in the late (inflammatory pain) phases of the formalin test. These effects were like those produced by TR. Concerning the results using the PIFIR model, RO extract (30-3000 mg/kg, p.o.) like either TR or AA, produced a significant (P < 0.001) and dose-dependent antinociceptive response in rats (RO: ED50 = 222.78 mg/kg versus TR: ED50 = 11.06 mg/kg and AA: ED50 = 206.13 mg/kg). These results strongly suggest that aerial parts of RO possess antinociceptive and anti-inflammatory activity, and reinforce the use of this plant in folk medicine.

Authors+Show Affiliations

Inst. Nac. de Psiquiatría Ramón de la Fuente Muñíz, Av. México-Xochimilco No. 101 Col. Sn Lorenzo Huipulco, 14370 México, D.F., Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17223299

Citation

González-Trujano, M E., et al. "Evaluation of the Antinociceptive Effect of Rosmarinus Officinalis L. Using Three Different Experimental Models in Rodents." Journal of Ethnopharmacology, vol. 111, no. 3, 2007, pp. 476-82.
González-Trujano ME, Peña EI, Martínez AL, et al. Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. J Ethnopharmacol. 2007;111(3):476-82.
González-Trujano, M. E., Peña, E. I., Martínez, A. L., Moreno, J., Guevara-Fefer, P., Déciga-Campos, M., & López-Muñoz, F. J. (2007). Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. Journal of Ethnopharmacology, 111(3), 476-82.
González-Trujano ME, et al. Evaluation of the Antinociceptive Effect of Rosmarinus Officinalis L. Using Three Different Experimental Models in Rodents. J Ethnopharmacol. 2007 May 22;111(3):476-82. PubMed PMID: 17223299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. AU - González-Trujano,M E, AU - Peña,E I, AU - Martínez,A L, AU - Moreno,J, AU - Guevara-Fefer,P, AU - Déciga-Campos,M, AU - López-Muñoz,F J, Y1 - 2006/12/17/ PY - 2006/05/30/received PY - 2006/12/12/revised PY - 2006/12/13/accepted PY - 2007/1/16/pubmed PY - 2007/7/27/medline PY - 2007/1/16/entrez SP - 476 EP - 82 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 111 IS - 3 N2 - The rationale of this investigation was to examine the antinociceptive effect of an ethanol extract of Rosmarinus officinalis (RO) aerial parts, using three different experimental models: acetic acid-induced writhing test and formalin test in mice; and a model of arthritic pain: "pain-induced functional impairment model in the rat (PIFIR model)". The antinociceptive efficacies were evaluated using several dose-response curves and time courses. The antinociceptive effects from RO extract were compared with the antinociceptive effect of either tramadol (TR: 3.16-50 mg/kg, i.p. in mice, and 1.0-31.62 mg/kg, i.p. in rats) or acetylsalicylic acid (AA: 31.62-562.32 mg/kg, p.o.). RO extract (10-300 mg/kg, p.o.) significantly (P < 0.001) reduced the number of writhing movement induced by the i.p. administration of acetic acid solution in a dose-dependent way (ED50 = 108.84 mg/kg, whereas, TR showed an ED50 = 12.38 mg/kg). In addition, RO extract (30-300 mg/kg) significantly (P < 0.001) inhibited licking and shaking behaviours in both early (neurogenic pain) and in the late (inflammatory pain) phases of the formalin test. These effects were like those produced by TR. Concerning the results using the PIFIR model, RO extract (30-3000 mg/kg, p.o.) like either TR or AA, produced a significant (P < 0.001) and dose-dependent antinociceptive response in rats (RO: ED50 = 222.78 mg/kg versus TR: ED50 = 11.06 mg/kg and AA: ED50 = 206.13 mg/kg). These results strongly suggest that aerial parts of RO possess antinociceptive and anti-inflammatory activity, and reinforce the use of this plant in folk medicine. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17223299/Evaluation_of_the_antinociceptive_effect_of_Rosmarinus_officinalis_L__using_three_different_experimental_models_in_rodents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00667-2 DB - PRIME DP - Unbound Medicine ER -