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Reduction in predicted coronary heart disease risk after substantial weight reduction after bariatric surgery.
Am J Cardiol. 2007 Jan 15; 99(2):222-6.AJ

Abstract

In recent years, bariatric surgery has become an increasingly used therapeutic option for morbid obesity. The effect of weight loss after bariatric surgery on the predicted risk of coronary heart disease (CHD) has not previously been studied. We evaluated baseline (preoperative) and follow-up (postoperative) body mass index, CHD risk factors, and Framingham risk scores (FRSs) for 109 consecutive patients with morbid obesity who lost weight after laparoscopic Roux-en-Y gastric bypass surgery. Charts were abstracted using a case-report form by a reviewer blinded to the FRS results. The study included 82 women (75%) and 27 men (25%) (mean age 46 +/- 10 years). Mean body mass index values at baseline and follow-up were 49 +/- 8 and 36 +/- 8 kg/m(2), respectively (p <0.0001). During an average follow-up of 17 months, diabetes, hypertension, and dyslipidemia resolved or improved after weight loss. Thus, the risks of CHD as predicted by FRS decreased by 39% in men and 25% in women. The predicted 10-year CHD risks at baseline and follow-up were 6 +/- 5% and 4 +/- 3%, respectively (p < or =0.0001). For those without CHD, men compared favorably with the age-matched general population, with a final 10-year risk of 5 +/- 4% versus an expected risk of 11 +/- 6% (p <0.0001). Likewise, women achieved a level below the age-adjusted expected 10-year risk of the general population, with a final risk of 3 +/- 3% versus 6 +/- 4% (p <0.0001). In conclusion, weight loss results in a significant decrease in FRS 10-year predicted CHD risk. Bariatric surgery decreases CHD risk to rates lower than the age- and gender-adjusted estimates for the general population. These data suggest substantial and sustained weight loss after bariatric surgery may be a powerful intervention to decrease future rates of myocardial infarction and death in the morbidly obese.

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Authors+Show Affiliations

Vogel JA
Department of Medicine, Division of Cardiology, Royal Oak, Michigan, USA.
Franklin BA
No affiliation info available
Zalesin KC
No affiliation info available
Trivax JE
No affiliation info available
Krause KR
No affiliation info available
Chengelis DL
No affiliation info available
McCullough PA
No affiliation info available

MeSH

Bariatric SurgeryBody Mass IndexCoronary DiseaseFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedObesityPostoperative PeriodPrognosisRetrospective StudiesRisk FactorsSex DistributionWeight Loss

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17223422

Citation

Vogel, Jody A., et al. "Reduction in Predicted Coronary Heart Disease Risk After Substantial Weight Reduction After Bariatric Surgery." The American Journal of Cardiology, vol. 99, no. 2, 2007, pp. 222-6.
Vogel JA, Franklin BA, Zalesin KC, et al. Reduction in predicted coronary heart disease risk after substantial weight reduction after bariatric surgery. Am J Cardiol. 2007;99(2):222-6.
Vogel, J. A., Franklin, B. A., Zalesin, K. C., Trivax, J. E., Krause, K. R., Chengelis, D. L., & McCullough, P. A. (2007). Reduction in predicted coronary heart disease risk after substantial weight reduction after bariatric surgery. The American Journal of Cardiology, 99(2), 222-6.
Vogel JA, et al. Reduction in Predicted Coronary Heart Disease Risk After Substantial Weight Reduction After Bariatric Surgery. Am J Cardiol. 2007 Jan 15;99(2):222-6. PubMed PMID: 17223422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction in predicted coronary heart disease risk after substantial weight reduction after bariatric surgery. AU - Vogel,Jody A, AU - Franklin,Barry A, AU - Zalesin,Kerstyn C, AU - Trivax,Justin E, AU - Krause,Kevin R, AU - Chengelis,David L, AU - McCullough,Peter A, Y1 - 2006/11/16/ PY - 2006/06/07/received PY - 2006/08/07/revised PY - 2006/08/07/accepted PY - 2007/1/16/pubmed PY - 2007/2/28/medline PY - 2007/1/16/entrez SP - 222 EP - 6 JF - The American journal of cardiology JO - Am J Cardiol VL - 99 IS - 2 N2 - In recent years, bariatric surgery has become an increasingly used therapeutic option for morbid obesity. The effect of weight loss after bariatric surgery on the predicted risk of coronary heart disease (CHD) has not previously been studied. We evaluated baseline (preoperative) and follow-up (postoperative) body mass index, CHD risk factors, and Framingham risk scores (FRSs) for 109 consecutive patients with morbid obesity who lost weight after laparoscopic Roux-en-Y gastric bypass surgery. Charts were abstracted using a case-report form by a reviewer blinded to the FRS results. The study included 82 women (75%) and 27 men (25%) (mean age 46 +/- 10 years). Mean body mass index values at baseline and follow-up were 49 +/- 8 and 36 +/- 8 kg/m(2), respectively (p <0.0001). During an average follow-up of 17 months, diabetes, hypertension, and dyslipidemia resolved or improved after weight loss. Thus, the risks of CHD as predicted by FRS decreased by 39% in men and 25% in women. The predicted 10-year CHD risks at baseline and follow-up were 6 +/- 5% and 4 +/- 3%, respectively (p < or =0.0001). For those without CHD, men compared favorably with the age-matched general population, with a final 10-year risk of 5 +/- 4% versus an expected risk of 11 +/- 6% (p <0.0001). Likewise, women achieved a level below the age-adjusted expected 10-year risk of the general population, with a final risk of 3 +/- 3% versus 6 +/- 4% (p <0.0001). In conclusion, weight loss results in a significant decrease in FRS 10-year predicted CHD risk. Bariatric surgery decreases CHD risk to rates lower than the age- and gender-adjusted estimates for the general population. These data suggest substantial and sustained weight loss after bariatric surgery may be a powerful intervention to decrease future rates of myocardial infarction and death in the morbidly obese. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17223422/Reduction_in_predicted_coronary_heart_disease_risk_after_substantial_weight_reduction_after_bariatric_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(06)02004-2 DB - PRIME DP - Unbound Medicine ER -