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Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence.
J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):752-6.JS

Abstract

There is strong epidemiological and laboratory evidence that vitamin D may be protective against colorectal neoplasia. Therefore, we sought to assess the relationship between serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence in our ursodeoxycholic acid trial. A total of 568 participants were randomly selected for analysis of serum 25(OH)D levels. The range of total 25(OH)D was 5.5-66.1 ng/ml, with a median of 25.6 ng/ml. After categorizing 25(OH)D levels into tertiles based on the population distribution, the adjusted odds ratios (95% CI) for adenoma recurrence in the second and third tertiles were 0.88 (0.56-1.39) and 0.78 (0.49-1.24), respectively. The association between serum 25(OH)D and adenoma recurrence appeared to be stronger among women than men. As compared to those below the median value, women with serum 25(OH)D levels above the median had an OR (95% CI) of 0.59 (0.30-1.16); the corresponding OR (95% CI) for men was 0.95 (0.60-1.49). Analyses by dietary vitamin D intake revealed no statistically significant associations. In summary, the results of this study show a moderate, nonsignificant inverse association between serum 25(OH)D levels and reduced risk for colorectal adenoma recurrence, particularly among women.

Authors+Show Affiliations

Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA. jacobse@u.arizona.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17223551

Citation

Jacobs, Elizabeth T., et al. "Serum 25(OH)D Levels, Dietary Intake of Vitamin D, and Colorectal Adenoma Recurrence." The Journal of Steroid Biochemistry and Molecular Biology, vol. 103, no. 3-5, 2007, pp. 752-6.
Jacobs ET, Alberts DS, Benuzillo J, et al. Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence. J Steroid Biochem Mol Biol. 2007;103(3-5):752-6.
Jacobs, E. T., Alberts, D. S., Benuzillo, J., Hollis, B. W., Thompson, P. A., & Martínez, M. E. (2007). Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence. The Journal of Steroid Biochemistry and Molecular Biology, 103(3-5), 752-6.
Jacobs ET, et al. Serum 25(OH)D Levels, Dietary Intake of Vitamin D, and Colorectal Adenoma Recurrence. J Steroid Biochem Mol Biol. 2007;103(3-5):752-6. PubMed PMID: 17223551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence. AU - Jacobs,Elizabeth T, AU - Alberts,David S, AU - Benuzillo,Jose, AU - Hollis,Bruce W, AU - Thompson,Patricia A, AU - Martínez,María Elena, Y1 - 2007/01/12/ PY - 2007/1/16/pubmed PY - 2007/5/12/medline PY - 2007/1/16/entrez SP - 752 EP - 6 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 103 IS - 3-5 N2 - There is strong epidemiological and laboratory evidence that vitamin D may be protective against colorectal neoplasia. Therefore, we sought to assess the relationship between serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence in our ursodeoxycholic acid trial. A total of 568 participants were randomly selected for analysis of serum 25(OH)D levels. The range of total 25(OH)D was 5.5-66.1 ng/ml, with a median of 25.6 ng/ml. After categorizing 25(OH)D levels into tertiles based on the population distribution, the adjusted odds ratios (95% CI) for adenoma recurrence in the second and third tertiles were 0.88 (0.56-1.39) and 0.78 (0.49-1.24), respectively. The association between serum 25(OH)D and adenoma recurrence appeared to be stronger among women than men. As compared to those below the median value, women with serum 25(OH)D levels above the median had an OR (95% CI) of 0.59 (0.30-1.16); the corresponding OR (95% CI) for men was 0.95 (0.60-1.49). Analyses by dietary vitamin D intake revealed no statistically significant associations. In summary, the results of this study show a moderate, nonsignificant inverse association between serum 25(OH)D levels and reduced risk for colorectal adenoma recurrence, particularly among women. SN - 0960-0760 UR - https://www.unboundmedicine.com/medline/citation/17223551/Serum_25_OH_D_levels_dietary_intake_of_vitamin_D_and_colorectal_adenoma_recurrence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(06)00415-8 DB - PRIME DP - Unbound Medicine ER -