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Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age.
Clin Endocrinol (Oxf). 2007 Feb; 66(2):290-4.CE

Abstract

OBJECTIVE

The aim of this study was to quantify serum adiponectin concentrations in short children born small for gestational age (SGA) compared with those in children born appropriate for gestational age (AGA), and to assess the relationship between the serum levels of adiponectin and insulin-like growth factor binding protein-1 (IGFBP-1) known as a predictor of the development of type 2 diabetes mellitus and cardiovascular disease.

SUBJECTS AND METHODS

Sixteen prepubertal short children born SGA and 20 short children born AGA, matched for age, body mass index, height, pubertal status, gestational age, bone age and midparental height, were included in the study. The serum levels of adiponectin, IGFBP-1, insulin and insulin-like growth factor-I (IGF-I) were measured in the fasting state.

RESULTS

The levels of serum adiponectin were significantly lower in the SGA than in AGA children (10.5 +/- 4.2 vs. 13.9 +/- 5.1 micro g/ml, P < 0.05). The levels of serum IGFBP-1, insulin and IGF-I were all similar in both groups. Overall, there was a significant positive correlation between adiponectin and IGFBP-1 (r = 0.40, P < 0.05).

CONCLUSIONS

Our results suggest that hypoadiponectinaemia in short SGA children without catch-up growth may reflect insulin resistance and imply a higher risk of developing type 2 diabetes mellitus. Additionally, adiponectin may be a more sensitive indicator for latent insulin resistance than IGFBP-1 in short SGA children.

Authors+Show Affiliations

Department of Pediatrics, University of Tsukuba, Ibaraki, Japan. tkamoda@md.tsukuba.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17224001

Citation

Kamoda, Tomohiro, et al. "Serum Levels of Adiponectin and IGFBP-1 in Short Children Born Small for Gestational Age." Clinical Endocrinology, vol. 66, no. 2, 2007, pp. 290-4.
Kamoda T, Nozue H, Matsui A. Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age. Clin Endocrinol (Oxf). 2007;66(2):290-4.
Kamoda, T., Nozue, H., & Matsui, A. (2007). Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age. Clinical Endocrinology, 66(2), 290-4.
Kamoda T, Nozue H, Matsui A. Serum Levels of Adiponectin and IGFBP-1 in Short Children Born Small for Gestational Age. Clin Endocrinol (Oxf). 2007;66(2):290-4. PubMed PMID: 17224001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age. AU - Kamoda,Tomohiro, AU - Nozue,Hiroki, AU - Matsui,Akira, PY - 2007/1/17/pubmed PY - 2007/7/19/medline PY - 2007/1/17/entrez SP - 290 EP - 4 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 66 IS - 2 N2 - OBJECTIVE: The aim of this study was to quantify serum adiponectin concentrations in short children born small for gestational age (SGA) compared with those in children born appropriate for gestational age (AGA), and to assess the relationship between the serum levels of adiponectin and insulin-like growth factor binding protein-1 (IGFBP-1) known as a predictor of the development of type 2 diabetes mellitus and cardiovascular disease. SUBJECTS AND METHODS: Sixteen prepubertal short children born SGA and 20 short children born AGA, matched for age, body mass index, height, pubertal status, gestational age, bone age and midparental height, were included in the study. The serum levels of adiponectin, IGFBP-1, insulin and insulin-like growth factor-I (IGF-I) were measured in the fasting state. RESULTS: The levels of serum adiponectin were significantly lower in the SGA than in AGA children (10.5 +/- 4.2 vs. 13.9 +/- 5.1 micro g/ml, P < 0.05). The levels of serum IGFBP-1, insulin and IGF-I were all similar in both groups. Overall, there was a significant positive correlation between adiponectin and IGFBP-1 (r = 0.40, P < 0.05). CONCLUSIONS: Our results suggest that hypoadiponectinaemia in short SGA children without catch-up growth may reflect insulin resistance and imply a higher risk of developing type 2 diabetes mellitus. Additionally, adiponectin may be a more sensitive indicator for latent insulin resistance than IGFBP-1 in short SGA children. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/17224001/Serum_levels_of_adiponectin_and_IGFBP_1_in_short_children_born_small_for_gestational_age_ L2 - https://doi.org/10.1111/j.1365-2265.2006.02724.x DB - PRIME DP - Unbound Medicine ER -