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Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology.
Fertil Steril. 2007 Apr; 87(4):870-5.FS

Abstract

OBJECTIVE

To evaluate the acute effects of metformin therapy on biochemical markers and polycystic ovarian morphology among insulin-resistant (IR) and noninsulin-resistant (NIR) patients with polycystic ovary syndrome (PCOS).

DESIGN

Prospective interventional study.

SETTING

Reproductive endocrinology clinic in a university hospital.

PATIENT(S)

Five IR and five NIR patients with PCOS. The mean age of patients was 29.5 +/- 4.8 years (range, 23-36 years).

INTERVENTION

Metformin therapy, using 850 mg orally per day for 1 week.

MAIN OUTCOME MEASURE(S)

Serum levels of T, FSH, and LH, fasting glucose/insulin ratio, levels of anti-Müllerian hormone (AMH) and inhibin B, and antral follicle count.

RESULT(S)

Levels of AMH and inhibin B were statistically significantly higher in patients with PCOS compared to controls (2.81 +/- 1.79 ng/mL versus 0.95 +/- 1.17 ng/mL, and 56.24 +/- 29.39 pg/mL versus 17.89 +/- 12.87 pg/mL, respectively). Levels of AMH and inhibin B were similar among IR and NIR patients with PCOS (2.77 +/- 1.92 ng/mL versus 2.85 +/- 1.89 ng/mL, and 53.96 +/- 28.58 pg/mL versus 58.51 +/- 33.28 pg/mL, respectively). One week of metformin therapy did not alter either AMH or inhibin B levels. However, there was a statistically significant increase in glucose/insulin ratios (4.59 +/- 1.57 versus 6.35 +/- 3.6), and a significant decrease in the number of antral follicles after 1 week of metformin therapy (38.8 +/- 19.3 versus 23.1 +/- 7.4).

CONCLUSION(S)

Levels of AMH and inhibin B are significantly increased in patients with PCOS compared to controls, but are not associated with insulin resistance. Low-dose metformin therapy improves IR and polycystic ovary morphology, even though levels of T, AMH, and inhibin B remain unchanged.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Southern California-Keck School of Medicine, Los Angeles, California, USA. Aykutb@aol.com <Aykutb@aol.com>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17224152

Citation

Bayrak, Aykut, et al. "Acute Effects of Metformin Therapy Include Improvement of Insulin Resistance and Ovarian Morphology." Fertility and Sterility, vol. 87, no. 4, 2007, pp. 870-5.
Bayrak A, Terbell H, Urwitz-Lane R, et al. Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology. Fertil Steril. 2007;87(4):870-5.
Bayrak, A., Terbell, H., Urwitz-Lane, R., Mor, E., Stanczyk, F. Z., & Paulson, R. J. (2007). Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology. Fertility and Sterility, 87(4), 870-5.
Bayrak A, et al. Acute Effects of Metformin Therapy Include Improvement of Insulin Resistance and Ovarian Morphology. Fertil Steril. 2007;87(4):870-5. PubMed PMID: 17224152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology. AU - Bayrak,Aykut, AU - Terbell,Heather, AU - Urwitz-Lane,Rebecca, AU - Mor,Eliran, AU - Stanczyk,Frank Z, AU - Paulson,Richard J, Y1 - 2007/01/16/ PY - 2005/10/17/received PY - 2006/08/31/revised PY - 2006/08/31/accepted PY - 2007/1/17/pubmed PY - 2007/5/2/medline PY - 2007/1/17/entrez SP - 870 EP - 5 JF - Fertility and sterility JO - Fertil Steril VL - 87 IS - 4 N2 - OBJECTIVE: To evaluate the acute effects of metformin therapy on biochemical markers and polycystic ovarian morphology among insulin-resistant (IR) and noninsulin-resistant (NIR) patients with polycystic ovary syndrome (PCOS). DESIGN: Prospective interventional study. SETTING: Reproductive endocrinology clinic in a university hospital. PATIENT(S): Five IR and five NIR patients with PCOS. The mean age of patients was 29.5 +/- 4.8 years (range, 23-36 years). INTERVENTION: Metformin therapy, using 850 mg orally per day for 1 week. MAIN OUTCOME MEASURE(S): Serum levels of T, FSH, and LH, fasting glucose/insulin ratio, levels of anti-Müllerian hormone (AMH) and inhibin B, and antral follicle count. RESULT(S): Levels of AMH and inhibin B were statistically significantly higher in patients with PCOS compared to controls (2.81 +/- 1.79 ng/mL versus 0.95 +/- 1.17 ng/mL, and 56.24 +/- 29.39 pg/mL versus 17.89 +/- 12.87 pg/mL, respectively). Levels of AMH and inhibin B were similar among IR and NIR patients with PCOS (2.77 +/- 1.92 ng/mL versus 2.85 +/- 1.89 ng/mL, and 53.96 +/- 28.58 pg/mL versus 58.51 +/- 33.28 pg/mL, respectively). One week of metformin therapy did not alter either AMH or inhibin B levels. However, there was a statistically significant increase in glucose/insulin ratios (4.59 +/- 1.57 versus 6.35 +/- 3.6), and a significant decrease in the number of antral follicles after 1 week of metformin therapy (38.8 +/- 19.3 versus 23.1 +/- 7.4). CONCLUSION(S): Levels of AMH and inhibin B are significantly increased in patients with PCOS compared to controls, but are not associated with insulin resistance. Low-dose metformin therapy improves IR and polycystic ovary morphology, even though levels of T, AMH, and inhibin B remain unchanged. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17224152/Acute_effects_of_metformin_therapy_include_improvement_of_insulin_resistance_and_ovarian_morphology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(06)04393-7 DB - PRIME DP - Unbound Medicine ER -