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Efficacy, predictors of response, and long-term follow-up in patients with vitiligo treated with narrowband UVB phototherapy.
J Am Acad Dermatol. 2007 Feb; 56(2):274-8.JA

Abstract

BACKGROUND

Narrowband UVB (NB-UVB) phototherapy is considered an accepted therapy for vitiligo.

OBJECTIVE

We sought to estimate the effectiveness of NB-UVB in patients with vitiligo, identify predictive factors of response, and assess the stability of NB-UVB-induced repigmentation.

METHODS

In all, 70 patients with vitiligo were treated twice weekly with NB-UVB.

RESULTS

Cosmetically acceptable (>75%) repigmentation was achieved in 34.4% of patients with lesions on the face and in 7.4% of patients with lesions on the body. Patients with phototypes III to V had a greater chance to achieve greater than 75% repigmentation on the face. Patients who responded in the first month of treatment were more likely to achieve better repigmentation rates. Repigmentation was stable in 14.3% of patients 4 years after cessation of treatment.

LIMITATIONS

The study was uncontrolled. Treatment frequency was twice weekly. These results may not be representative of different treatment regimens.

CONCLUSION

Patients with vitiligo who have lesions on the face, darker phototypes, and early response to treatment have a greater chance to achieve satisfactory repigmentation after NB-UVB phototherapy.

Authors+Show Affiliations

First Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17224369

Citation

Nicolaidou, Electra, et al. "Efficacy, Predictors of Response, and Long-term Follow-up in Patients With Vitiligo Treated With Narrowband UVB Phototherapy." Journal of the American Academy of Dermatology, vol. 56, no. 2, 2007, pp. 274-8.
Nicolaidou E, Antoniou C, Stratigos AJ, et al. Efficacy, predictors of response, and long-term follow-up in patients with vitiligo treated with narrowband UVB phototherapy. J Am Acad Dermatol. 2007;56(2):274-8.
Nicolaidou, E., Antoniou, C., Stratigos, A. J., Stefanaki, C., & Katsambas, A. D. (2007). Efficacy, predictors of response, and long-term follow-up in patients with vitiligo treated with narrowband UVB phototherapy. Journal of the American Academy of Dermatology, 56(2), 274-8.
Nicolaidou E, et al. Efficacy, Predictors of Response, and Long-term Follow-up in Patients With Vitiligo Treated With Narrowband UVB Phototherapy. J Am Acad Dermatol. 2007;56(2):274-8. PubMed PMID: 17224369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy, predictors of response, and long-term follow-up in patients with vitiligo treated with narrowband UVB phototherapy. AU - Nicolaidou,Electra, AU - Antoniou,Christina, AU - Stratigos,Alexander J, AU - Stefanaki,Christina, AU - Katsambas,Andreas D, PY - 2006/04/25/received PY - 2006/09/04/revised PY - 2006/09/06/accepted PY - 2007/1/17/pubmed PY - 2007/2/7/medline PY - 2007/1/17/entrez SP - 274 EP - 8 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 56 IS - 2 N2 - BACKGROUND: Narrowband UVB (NB-UVB) phototherapy is considered an accepted therapy for vitiligo. OBJECTIVE: We sought to estimate the effectiveness of NB-UVB in patients with vitiligo, identify predictive factors of response, and assess the stability of NB-UVB-induced repigmentation. METHODS: In all, 70 patients with vitiligo were treated twice weekly with NB-UVB. RESULTS: Cosmetically acceptable (>75%) repigmentation was achieved in 34.4% of patients with lesions on the face and in 7.4% of patients with lesions on the body. Patients with phototypes III to V had a greater chance to achieve greater than 75% repigmentation on the face. Patients who responded in the first month of treatment were more likely to achieve better repigmentation rates. Repigmentation was stable in 14.3% of patients 4 years after cessation of treatment. LIMITATIONS: The study was uncontrolled. Treatment frequency was twice weekly. These results may not be representative of different treatment regimens. CONCLUSION: Patients with vitiligo who have lesions on the face, darker phototypes, and early response to treatment have a greater chance to achieve satisfactory repigmentation after NB-UVB phototherapy. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/17224369/Efficacy_predictors_of_response_and_long_term_follow_up_in_patients_with_vitiligo_treated_with_narrowband_UVB_phototherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(06)02529-1 DB - PRIME DP - Unbound Medicine ER -