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In vivo estimation of stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy.
Acta Derm Venereol. 2007; 87(1):4-8.AD

Abstract

Stratum corneum thickness was estimated from water concentration profiles of the skin measured by a confocal Raman spectrometer. Stratum corneum apparent thickness (SCAT) was defined as the depth where the water content reached an almost constant value. Site variations were determined using 15 healthy Japanese subjects (6 males, 9 females), and age variations at the cheek and forearm were examined using 27 female Japanese subjects. There were marked site variations in mean SCAT; 16.8 microm for cheek, 22.6 microm for volar forearm, 29.3 microm for back of the hand, and 173.0 microm for palm. These variations were similar to reported stratum corneum thickness values obtained in biopsy tissues. The SCAT tended to become age-dependently thicker at the forearm, but not at the cheek. In addition, SCAT was increased up to two-fold by hydration for 90 min, while lesser increases were seen with shorter hydration periods.

Authors+Show Affiliations

Egawa M
Life Science Research Center, Shiseido Co., 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama, Japan. mariko.egawa@to.shiseido.co.jp
Hirao T
No affiliation info available
Takahashi M
No affiliation info available

MeSH

AdultAgedBody WaterEpidermisFemaleHumansHumidityMaleMiddle AgedSkin Physiological PhenomenaSpectrum Analysis, Raman

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17225007

Citation

Egawa, Mariko, et al. "In Vivo Estimation of Stratum Corneum Thickness From Water Concentration Profiles Obtained With Raman Spectroscopy." Acta Dermato-venereologica, vol. 87, no. 1, 2007, pp. 4-8.
Egawa M, Hirao T, Takahashi M. In vivo estimation of stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy. Acta Derm Venereol. 2007;87(1):4-8.
Egawa, M., Hirao, T., & Takahashi, M. (2007). In vivo estimation of stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy. Acta Dermato-venereologica, 87(1), 4-8.
Egawa M, Hirao T, Takahashi M. In Vivo Estimation of Stratum Corneum Thickness From Water Concentration Profiles Obtained With Raman Spectroscopy. Acta Derm Venereol. 2007;87(1):4-8. PubMed PMID: 17225007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo estimation of stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy. AU - Egawa,Mariko, AU - Hirao,Tetsuji, AU - Takahashi,Motoji, PY - 2007/1/17/pubmed PY - 2007/5/30/medline PY - 2007/1/17/entrez SP - 4 EP - 8 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 87 IS - 1 N2 - Stratum corneum thickness was estimated from water concentration profiles of the skin measured by a confocal Raman spectrometer. Stratum corneum apparent thickness (SCAT) was defined as the depth where the water content reached an almost constant value. Site variations were determined using 15 healthy Japanese subjects (6 males, 9 females), and age variations at the cheek and forearm were examined using 27 female Japanese subjects. There were marked site variations in mean SCAT; 16.8 microm for cheek, 22.6 microm for volar forearm, 29.3 microm for back of the hand, and 173.0 microm for palm. These variations were similar to reported stratum corneum thickness values obtained in biopsy tissues. The SCAT tended to become age-dependently thicker at the forearm, but not at the cheek. In addition, SCAT was increased up to two-fold by hydration for 90 min, while lesser increases were seen with shorter hydration periods. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/17225007/In_vivo_estimation_of_stratum_corneum_thickness_from_water_concentration_profiles_obtained_with_Raman_spectroscopy_ DB - PRIME DP - Unbound Medicine ER -