Prime

Type your tag names separated by a space and hit enter

Course of Borrelia burgdorferi DNA shedding in urine after treatment.

Abstract

Diagnosis of Lyme borreliosis by urine polymerase chain reaction (PCR) has been recognized as having better diagnostic sensitivity in patients with erythema migrans than serological methods. We made serial tests with 192 urine specimens from 70 patients with erythema migrans and 60 urine specimens from 21 patients with acrodermatitis chronica atrophicans to evaluate the course of positive urine PCR after antibiotic treatment. Before treatment, urine samples from patients with erythema migrans showed a positive PCR in 27/34 samples (79%), and those from patients with acrodermatitis chronica atrophicans in 7/11 (63%). The specificity of bands was proven by hybridization with GEN-ETI-KTM-DEIA kit in 40/41 samples. Borrelia DNA in urine decreased gradually within the observation period of one year in both patients with erythema migrans and acrodermatitis chronica atrophicans, and persisted without clinical symptoms in 4/45 patients with erythema migrans (8%) after 12 months. Urine PCR can serve as a diagnostic method in early Lyme borreliosis and also in seropositive patients with unclear clinical symptoms.

Links

  • FREE Publisher Full Text
  • Authors

    , , ,

    Source

    Acta dermato-venereologica 87:1 2007 pg 39-42

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Anti-Bacterial Agents
    Borrelia burgdorferi
    Child
    DNA, Bacterial
    Erythema Chronicum Migrans
    Female
    Humans
    Lyme Disease
    Male
    Middle Aged
    Polymerase Chain Reaction

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    17225014