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The origins of concentric demyelination: self-organization in the human brain.
PLoS One. 2007 Jan 17; 2(1):e150.Plos

Abstract

Baló's concentric sclerosis is a rare atypical form of multiple sclerosis characterized by striking concentric demyelination patterns. We propose a robust mathematical model for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis. A reconsideration of the analogies between Baló's sclerosis and the Liesegang periodic precipitation phenomenon led us to propose a chemotactic cellular model for this disease. Rings of demyelination appear as a result of self-organization processes, and closely mimic Baló lesions. According to our results, homogeneous and concentric demyelinations may be two different macroscopic outcomes of a single fundamental immune disorder. Furthermore, in chemotactic models, cellular aggressivity appears to play a central role in pattern formation.

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Publisher Full Text
ncbi.nlm.nih.gov
dx.plos.org
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Authors+Show Affiliations

Khonsari RH
Service de Chirurgie Maxillofaciale, Centre Hospitalier Universitaire de Nantes, Nantes, France. hossein.khonsari@ens.fr
Calvez V
No affiliation info available

MeSH

BrainChemotaxisDemyelinating DiseasesDiffuse Cerebral Sclerosis of SchilderHumansModels, Theoretical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17225855

Citation

Khonsari, Roman H., and Vincent Calvez. "The Origins of Concentric Demyelination: Self-organization in the Human Brain." PloS One, vol. 2, no. 1, 2007, pp. e150.
Khonsari RH, Calvez V. The origins of concentric demyelination: self-organization in the human brain. PLoS One. 2007;2(1):e150.
Khonsari, R. H., & Calvez, V. (2007). The origins of concentric demyelination: self-organization in the human brain. PloS One, 2(1), e150.
Khonsari RH, Calvez V. The Origins of Concentric Demyelination: Self-organization in the Human Brain. PLoS One. 2007 Jan 17;2(1):e150. PubMed PMID: 17225855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The origins of concentric demyelination: self-organization in the human brain. AU - Khonsari,Roman H, AU - Calvez,Vincent, Y1 - 2007/01/17/ PY - 2006/08/25/received PY - 2006/12/01/accepted PY - 2007/1/18/pubmed PY - 2007/1/18/medline PY - 2007/1/18/entrez SP - e150 EP - e150 JF - PloS one JO - PLoS One VL - 2 IS - 1 N2 - Baló's concentric sclerosis is a rare atypical form of multiple sclerosis characterized by striking concentric demyelination patterns. We propose a robust mathematical model for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis. A reconsideration of the analogies between Baló's sclerosis and the Liesegang periodic precipitation phenomenon led us to propose a chemotactic cellular model for this disease. Rings of demyelination appear as a result of self-organization processes, and closely mimic Baló lesions. According to our results, homogeneous and concentric demyelinations may be two different macroscopic outcomes of a single fundamental immune disorder. Furthermore, in chemotactic models, cellular aggressivity appears to play a central role in pattern formation. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/17225855/The_origins_of_concentric_demyelination:_self_organization_in_the_human_brain_ L2 - https://dx.plos.org/10.1371/journal.pone.0000150 DB - PRIME DP - Unbound Medicine ER -